Overexpression of Hsp25 in K1735 murine melanoma cells enhances susceptibility to natural killer cytotoxicity

In the present study we used a murine melanoma model to investigate the effect of the 25-kDa heat shock protein (Hsp25) on natural killer (NK) cytotoxicity. The melanoma lines K1735-Cl23 (low metastatic potential) and K1735-M2 (high metastatic potential) were transfected with hsp25 and a control pla...

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Veröffentlicht in:	Cell stress & chaperones 2002-01, Vol.7 (1), p.107-117
Hauptverfasser:	Jantschitsch, Christian, Trautinger, Franz, Klosner, Gabriele, Gsur, Andrea, Herbacek, Irene, Micksche, Michael, Kindås-Mügge, Ingela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B lymphocytes Cell lines Cytotoxicity Cytotoxicity Tests, Immunologic Flow Cytometry Gene Expression Regulation, Neoplastic - immunology Heat shock proteins Histocompatibility Antigens Class II - metabolism Killer Cells, Natural - immunology Lymphocytes Melanoma Mice Mice, Inbred C3H Natural killer cells Neoplasm Metastasis - immunology Neoplasm Proteins - genetics Neoplasm Proteins - immunology Original Original s Tumor cell line Tumor Cells, Cultured - immunology Tumors
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