Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons

Astrocytes are critical in synapse development, and their dysfunction in crucial developmental stages leads to serious neurodevelopmental diseases, including seizures and epilepsy. Immune challenges not only affect brain development, but also promote seizure generation and epileptogenesis, implying...

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Veröffentlicht in:	The Journal of cell biology 2016-12, Vol.215 (5), p.719-734
Hauptverfasser:	Shen, Yi, Qin, Huaping, Chen, Juan, Mou, Lingyan, He, Yang, Yan, Yixiu, Zhou, Hang, Lv, Ya, Chen, Zhong, Wang, Junlu, Zhou, Yu-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Astrocytes - metabolism Biochemistry Coculture Techniques Convulsions & seizures Dendrites - metabolism Disease Susceptibility Enzyme Activation Epilepsy Extracellular Signal-Regulated MAP Kinases - metabolism Hippocampus - pathology Immunology Kinases Lipopolysaccharides Mice Mice, Inbred C57BL Myeloid Differentiation Factor 88 - metabolism Neurodegeneration Neurogenesis Neurons - metabolism Pentylenetetrazole Pyramidal Cells - metabolism Seizures - pathology Signal Transduction Synapses - metabolism Synaptic Transmission Toll-Like Receptor 4 - metabolism
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