Essential structural and functional determinants within the forkhead domain of FOXC1

The forkhead domain (FHD)-containing developmental transcription factor FOXC1 is mutated in patients presenting with Axenfeld–Rieger malformations. In this paper, we report the introduction of positive, negative or neutral charged amino acids into critical positions within the forkhead domain of FOX...

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Veröffentlicht in:	Nucleic acids research 2004, Vol.32 (14), p.4182-4193
Hauptverfasser:	Saleem, R. A., Banerjee-Basu, S., Murphy, T. C., Baxevanis, A., Walter, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - physiology Animals Blotting, Western Cell Line Cell Nucleus - chemistry DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Forkhead Transcription Factors Humans Models, Molecular Molecular Sequence Data Mutation Protein Structure, Secondary Protein Structure, Tertiary Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation
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