NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance

Sorafenib, an oral multikinase inhibitor, is the only approved agent for the treatment of advanced hepatocellular carcinoma (HCC). However, its benefits are modest, and as its mechanisms of action remain elusive, a better understanding of its anticancer effects is needed. Based on our previous study...

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Veröffentlicht in:	Cell death & disease 2016-06, Vol.7 (6), p.e2269-e2269
Hauptverfasser:	Emma, M R, Iovanna, J L, Bachvarov, D, Puleio, R, Loria, G R, Augello, G, Candido, S, Libra, M, Gulino, A, Cancila, V, McCubrey, J A, Montalto, G, Cervello, M
Format:	Artikel
Sprache:	eng
Schlagworte:	38/61 38/89 631/67/1059/602 631/80/82 631/80/86 692/4028/67/1504/1610/4029 Aged Aged, 80 and over Antibodies Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biochemistry Biomedical and Life Sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell adhesion & migration Cell Biology Cell Culture Cell growth Cell Movement - drug effects Cell Movement - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Cell Survival - drug effects Cell Survival - genetics Computational Biology Core Binding Factor Alpha 1 Subunit - metabolism Down-Regulation - drug effects Drug Resistance, Neoplasm - drug effects Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Gene Silencing - drug effects Humans Immunology Life Sciences Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Male Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Molecular Targeted Therapy Neoplasm Invasiveness Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Original original-article Phenylurea Compounds - pharmacology Proteins RNA, Small Interfering - metabolism Sorafenib Transcription Factor RelB - genetics Transcription Factor RelB - metabolism Transcriptome - genetics Young Adult
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