Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction
Atherosclerosis is one of the most common vascular disorders. Endothelial cell (EC) dysfunction and vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis. Long non-coding RNAs (lncRNAs) have been implicated in several biological processes and human diseas...
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| Veröffentlicht in: | Cell death & disease 2016-06, Vol.7 (6), p.e2248-e2248 |
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| creator | Shan, K Jiang, Q Wang, X -Q Wang, Y -N -Z Yang, H Yao, M -D Liu, C Li, X -M Yao, J Liu, B Zhang, Y -Y J, Yong Yan, B |
| description | Atherosclerosis is one of the most common vascular disorders. Endothelial cell (EC) dysfunction and vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis. Long non-coding RNAs (lncRNAs) have been implicated in several biological processes and human diseases. Here we show that lncRNA-RNCR3 is expressed in ECs and VSMCs. RNCR3 expression is significantly upregulated in mouse and human aortic atherosclerotic lesions, and cultured ECs and VSMCs upon ox-LDL treatment
in vitro
. RNCR3 knockdown accelerates the development of atherosclerosis, aggravates hypercholesterolemia and inflammatory factor releases, and decreases EC and VSMC proliferation
in vivo
. RNCR3 knockdown also reduces the proliferation and migration, and accelerates apoptosis development of EC and VSMC
in vitro.
RNCR3 acts as a ceRNA, and forms a feedback loop with Kruppel-like factor 2 and miR-185-5p to regulate cell function. This study reveals that RNCR3 has an atheroprotective role in atherosclerosis, and its intervention is a promising strategy for treating atherosclerosis-related vascular dysfunction. |
| doi_str_mv | 10.1038/cddis.2016.145 |
| format | Article |
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in vitro
. RNCR3 knockdown accelerates the development of atherosclerosis, aggravates hypercholesterolemia and inflammatory factor releases, and decreases EC and VSMC proliferation
in vivo
. RNCR3 knockdown also reduces the proliferation and migration, and accelerates apoptosis development of EC and VSMC
in vitro.
RNCR3 acts as a ceRNA, and forms a feedback loop with Kruppel-like factor 2 and miR-185-5p to regulate cell function. This study reveals that RNCR3 has an atheroprotective role in atherosclerosis, and its intervention is a promising strategy for treating atherosclerosis-related vascular dysfunction.</description><identifier>ISSN: 2041-4889</identifier><identifier>EISSN: 2041-4889</identifier><identifier>DOI: 10.1038/cddis.2016.145</identifier><identifier>PMID: 27253412</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337/384/2568 ; 631/443/592/75/593/2100 ; 631/80/82/23 ; Animals ; Antibodies ; Aorta - pathology ; Atherosclerosis ; Atherosclerosis - genetics ; Atherosclerosis - pathology ; Atherosclerosis - physiopathology ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cell Communication ; Cell Culture ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Exosomes - metabolism ; Gene expression ; Gene Knockdown Techniques ; Humans ; Hypercholesterolemia - genetics ; Hypercholesterolemia - pathology ; Immunology ; Inflammation Mediators - metabolism ; Life Sciences ; Male ; Mice, Inbred C57BL ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Muscle, Smooth, Vascular - metabolism ; Myocytes, Smooth Muscle - pathology ; Original ; original-article ; Retina - metabolism ; Retina - pathology ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Up-Regulation - genetics</subject><ispartof>Cell death & disease, 2016-06, Vol.7 (6), p.e2248-e2248</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jun 2016</rights><rights>Copyright © 2016 Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-23e4db4ea8e2cd6f39e091b650fba4592a5a9b51f0f14bd516243b2ecd6122b53</citedby><cites>FETCH-LOGICAL-c557t-23e4db4ea8e2cd6f39e091b650fba4592a5a9b51f0f14bd516243b2ecd6122b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143375/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143375/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27253412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shan, K</creatorcontrib><creatorcontrib>Jiang, Q</creatorcontrib><creatorcontrib>Wang, X -Q</creatorcontrib><creatorcontrib>Wang, Y -N -Z</creatorcontrib><creatorcontrib>Yang, H</creatorcontrib><creatorcontrib>Yao, M -D</creatorcontrib><creatorcontrib>Liu, C</creatorcontrib><creatorcontrib>Li, X -M</creatorcontrib><creatorcontrib>Yao, J</creatorcontrib><creatorcontrib>Liu, B</creatorcontrib><creatorcontrib>Zhang, Y -Y</creatorcontrib><creatorcontrib>J, Yong</creatorcontrib><creatorcontrib>Yan, B</creatorcontrib><title>Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction</title><title>Cell death & disease</title><addtitle>Cell Death Dis</addtitle><addtitle>Cell Death Dis</addtitle><description>Atherosclerosis is one of the most common vascular disorders. Endothelial cell (EC) dysfunction and vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis. Long non-coding RNAs (lncRNAs) have been implicated in several biological processes and human diseases. Here we show that lncRNA-RNCR3 is expressed in ECs and VSMCs. RNCR3 expression is significantly upregulated in mouse and human aortic atherosclerotic lesions, and cultured ECs and VSMCs upon ox-LDL treatment
in vitro
. RNCR3 knockdown accelerates the development of atherosclerosis, aggravates hypercholesterolemia and inflammatory factor releases, and decreases EC and VSMC proliferation
in vivo
. RNCR3 knockdown also reduces the proliferation and migration, and accelerates apoptosis development of EC and VSMC
in vitro.
RNCR3 acts as a ceRNA, and forms a feedback loop with Kruppel-like factor 2 and miR-185-5p to regulate cell function. This study reveals that RNCR3 has an atheroprotective role in atherosclerosis, and its intervention is a promising strategy for treating atherosclerosis-related vascular dysfunction.</description><subject>631/337/384/2568</subject><subject>631/443/592/75/593/2100</subject><subject>631/80/82/23</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Aorta - pathology</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - genetics</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerosis - physiopathology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Communication</subject><subject>Cell Culture</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Exosomes - metabolism</subject><subject>Gene expression</subject><subject>Gene Knockdown Techniques</subject><subject>Humans</subject><subject>Hypercholesterolemia - genetics</subject><subject>Hypercholesterolemia - pathology</subject><subject>Immunology</subject><subject>Inflammation Mediators - metabolism</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Myocytes, Smooth Muscle - pathology</subject><subject>Original</subject><subject>original-article</subject><subject>Retina - metabolism</subject><subject>Retina - pathology</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Up-Regulation - genetics</subject><issn>2041-4889</issn><issn>2041-4889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkd9LHDEQx0NpqWJ97WNZ6Etf9szP3eSlIEfVgig92ueQTWbPSC6xya7gf9-cp3ItBfMwGZjPfCeZL0IfCV4QzOSJdc6XBcWkWxAu3qBDijlpuZTq7V5-gI5LucX1MIap6N6jA9pTwTihh-jHKgVo0tiEFNdNTLG1yfmarq5O29XVcsUaHxsz3UBOxYZt9KXNEMwErrk3xc7B5MY9lHGOdvIpfkDvRhMKHD_dR-jX2befy4v28vr8-_L0srVC9FNLGXA3cDASqHXdyBRgRYZO4HEwXChqhFGDICMeCR-cIB3lbKBQWULpINgR-rrTvZuHDTgLccom6LvsNyY_6GS8_rsS_Y1ep3stCGes3wp8eRLI6fcMZdIbXyyEYCKkuWgisexpL3v1OloZhSVVvKKf_0Fv05xj3cQjRZVkuKvUYkfZutCSYXx5N8F6661-9FZvvdXV29rwaf-3L_izkxU42QGlluIa8t7c_0v-Aahzr5M</recordid><startdate>20160602</startdate><enddate>20160602</enddate><creator>Shan, K</creator><creator>Jiang, Q</creator><creator>Wang, X -Q</creator><creator>Wang, Y -N -Z</creator><creator>Yang, H</creator><creator>Yao, M -D</creator><creator>Liu, C</creator><creator>Li, X -M</creator><creator>Yao, J</creator><creator>Liu, B</creator><creator>Zhang, Y -Y</creator><creator>J, Yong</creator><creator>Yan, B</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20160602</creationdate><title>Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction</title><author>Shan, K ; Jiang, Q ; Wang, X -Q ; Wang, Y -N -Z ; Yang, H ; Yao, M -D ; Liu, C ; Li, X -M ; Yao, J ; Liu, B ; Zhang, Y -Y ; J, Yong ; Yan, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-23e4db4ea8e2cd6f39e091b650fba4592a5a9b51f0f14bd516243b2ecd6122b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/337/384/2568</topic><topic>631/443/592/75/593/2100</topic><topic>631/80/82/23</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Aorta - pathology</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - genetics</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerosis - physiopathology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cell Communication</topic><topic>Cell Culture</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Exosomes - metabolism</topic><topic>Gene expression</topic><topic>Gene Knockdown Techniques</topic><topic>Humans</topic><topic>Hypercholesterolemia - genetics</topic><topic>Hypercholesterolemia - pathology</topic><topic>Immunology</topic><topic>Inflammation Mediators - metabolism</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Myocytes, Smooth Muscle - pathology</topic><topic>Original</topic><topic>original-article</topic><topic>Retina - metabolism</topic><topic>Retina - pathology</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Up-Regulation - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shan, K</creatorcontrib><creatorcontrib>Jiang, Q</creatorcontrib><creatorcontrib>Wang, X -Q</creatorcontrib><creatorcontrib>Wang, Y -N -Z</creatorcontrib><creatorcontrib>Yang, H</creatorcontrib><creatorcontrib>Yao, M -D</creatorcontrib><creatorcontrib>Liu, C</creatorcontrib><creatorcontrib>Li, X -M</creatorcontrib><creatorcontrib>Yao, J</creatorcontrib><creatorcontrib>Liu, B</creatorcontrib><creatorcontrib>Zhang, Y -Y</creatorcontrib><creatorcontrib>J, Yong</creatorcontrib><creatorcontrib>Yan, B</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell death & disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shan, K</au><au>Jiang, Q</au><au>Wang, X -Q</au><au>Wang, Y -N -Z</au><au>Yang, H</au><au>Yao, M -D</au><au>Liu, C</au><au>Li, X -M</au><au>Yao, J</au><au>Liu, B</au><au>Zhang, Y -Y</au><au>J, Yong</au><au>Yan, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction</atitle><jtitle>Cell death & disease</jtitle><stitle>Cell Death Dis</stitle><addtitle>Cell Death Dis</addtitle><date>2016-06-02</date><risdate>2016</risdate><volume>7</volume><issue>6</issue><spage>e2248</spage><epage>e2248</epage><pages>e2248-e2248</pages><issn>2041-4889</issn><eissn>2041-4889</eissn><abstract>Atherosclerosis is one of the most common vascular disorders. Endothelial cell (EC) dysfunction and vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis. Long non-coding RNAs (lncRNAs) have been implicated in several biological processes and human diseases. Here we show that lncRNA-RNCR3 is expressed in ECs and VSMCs. RNCR3 expression is significantly upregulated in mouse and human aortic atherosclerotic lesions, and cultured ECs and VSMCs upon ox-LDL treatment
in vitro
. RNCR3 knockdown accelerates the development of atherosclerosis, aggravates hypercholesterolemia and inflammatory factor releases, and decreases EC and VSMC proliferation
in vivo
. RNCR3 knockdown also reduces the proliferation and migration, and accelerates apoptosis development of EC and VSMC
in vitro.
RNCR3 acts as a ceRNA, and forms a feedback loop with Kruppel-like factor 2 and miR-185-5p to regulate cell function. This study reveals that RNCR3 has an atheroprotective role in atherosclerosis, and its intervention is a promising strategy for treating atherosclerosis-related vascular dysfunction.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27253412</pmid><doi>10.1038/cddis.2016.145</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/337/384/2568 631/443/592/75/593/2100 631/80/82/23 Animals Antibodies Aorta - pathology Atherosclerosis Atherosclerosis - genetics Atherosclerosis - pathology Atherosclerosis - physiopathology Biochemistry Biomedical and Life Sciences Cell Biology Cell Communication Cell Culture Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Exosomes - metabolism Gene expression Gene Knockdown Techniques Humans Hypercholesterolemia - genetics Hypercholesterolemia - pathology Immunology Inflammation Mediators - metabolism Life Sciences Male Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - pathology Original original-article Retina - metabolism Retina - pathology Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Up-Regulation - genetics |
| title | Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction |
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