C/EBPβ regulates homeostatic and oncogenic gastric cell proliferation

Cancer of the stomach is among the leading causes of death from cancer worldwide. The transcription factor C/EBPβ is frequently overexpressed in gastric cancer and associated with the suppression of the differentiation marker TFF1. We show that the murine C/EBPβ knockout stomach displays unbalanced...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2016-12, Vol.94 (12), p.1385-1395
Hauptverfasser:	Regalo, Goncalo, Förster, Susann, Resende, Carlos, Bauer, Bianca, Fleige, Barbara, Kemmner, Wolfgang, Schlag, Peter M., Meyer, Thomas F., Machado, José C., Leutz, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Biomedical and Life Sciences Biomedicine Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology CCAAT-Enhancer-Binding Protein-beta - antagonists & inhibitors CCAAT-Enhancer-Binding Protein-beta - deficiency CCAAT-Enhancer-Binding Protein-beta - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism Cell Line, Tumor Cell Proliferation Gene Expression Profiling Gene Expression Regulation, Neoplastic Homeostasis - genetics Human Genetics Humans Internal Medicine Male Mice Mice, Knockout Mice, Nude Molecular Medicine Neoplasm Transplantation Original Original Article RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RUNX1 Translocation Partner 1 Protein - genetics RUNX1 Translocation Partner 1 Protein - metabolism Signal Transduction Stomach - metabolism Stomach - pathology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Trefoil Factor-1 - genetics Trefoil Factor-1 - metabolism
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