CD44 Expression Level and Isoform Contributes to Pancreatic Cancer Cell Plasticity, Invasiveness, and Response to Therapy

A subpopulation of pancreatic ductal adenocarcinoma (PDAC) cells is thought to be inherently resistant to chemotherapy or to give rise to tumor cells that become resistant during treatment. Here we determined the role of CD44 expression and its isoforms as a marker and potential target for tumor cel...

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Veröffentlicht in:	Clinical cancer research 2016-11, Vol.22 (22), p.5592-5604
Hauptverfasser:	Zhao, Shujie, Chen, Chen, Chang, Katherine, Karnad, Anand, Jagirdar, Jaishree, Kumar, Addanki P, Freeman, James W
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Cell Movement - drug effects Cell Movement - physiology Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Gemcitabine Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - physiology Humans Hyaluronan Receptors - metabolism Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Protein Isoforms - metabolism RNA, Small Interfering - metabolism
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