MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies

Abstract Introduction The MAPT H1 haplotype has been associated with several neurodegenerative diseases. We were interested in exploring the role of MAPT haplotypic variation in risk of dementia with Lewy bodies (DLB). Method We genotyped six MAPT haplotype tagging SNPs and screened 431 clinical DLB...

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Veröffentlicht in:	Alzheimer's & dementia 2016-12, Vol.12 (12), p.1297-1304
Hauptverfasser:	Labbé, Catherine, Heckman, Michael G, Lorenzo-Betancor, Oswaldo, Soto-Ortolaza, Alexandra I, Walton, Ronald L, Murray, Melissa E, Allen, Mariet, Uitti, Ryan J, Wszolek, Zbigniew K, Smith, Glenn E, Kantarci, Kejal, Knopman, David S, Lowe, Val J, Jack, Clifford R, Ertekin-Taner, Nilüfer, Hassan, Anhar, Savica, Rodolfo, Petersen, Ronald C, Parisi, Joseph E, Maraganore, Demetrius M, Graff-Radford, Neill R, Ferman, Tanis J, Boeve, Bradley F, Dickson, Dennis W, Ross, Owen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - metabolism Dementia with Lewy bodies Genetic Association Studies Genetic association study Genetic Predisposition to Disease Genotype Haplotypes - genetics Humans Lewy body disease Lewy Body Disease - genetics MAPT Neurology Polymorphism, Single Nucleotide tau protein tau Proteins - genetics
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