Lipid signalling in pathogenic fungi
In recent years, the study of lipid signalling networks has significantly increased. Although best studied in mammalian cells, lipid signalling is now appreciated also in microbial cells, particularly in yeasts and moulds. For instance, microbial sphingolipids and their metabolizing enzymes play a k...
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| Veröffentlicht in: | Cellular microbiology 2011-02, Vol.13 (2), p.177-185 |
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| creator | Singh, Arpita Del Poeta, Maurizio |
| description | In recent years, the study of lipid signalling networks has significantly increased. Although best studied in mammalian cells, lipid signalling is now appreciated also in microbial cells, particularly in yeasts and moulds. For instance, microbial sphingolipids and their metabolizing enzymes play a key role in the regulation of fungal pathogenicity, especially in Cryptococcus neoformans, through the modulation of different microbial pathways and virulence factors. Another example is the quorum sensing molecule (QSM) farnesol. In fact, this QSM is involved not only in mycelial growth and biofilm formation of Candida albicans, but also in many stress related responses. In moulds, such as Aspergillus fumigatus, QSM and sphingolipids are important for maintaining cell wall integrity and virulence. Finally, fungal cells make oxylipins to increase their virulence attributes and to counteract the host immune defences. In this review, we discuss these aspects in details. |
| doi_str_mv | 10.1111/j.1462-5822.2010.01550.x |
| format | Article |
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Although best studied in mammalian cells, lipid signalling is now appreciated also in microbial cells, particularly in yeasts and moulds. For instance, microbial sphingolipids and their metabolizing enzymes play a key role in the regulation of fungal pathogenicity, especially in Cryptococcus neoformans, through the modulation of different microbial pathways and virulence factors. Another example is the quorum sensing molecule (QSM) farnesol. In fact, this QSM is involved not only in mycelial growth and biofilm formation of Candida albicans, but also in many stress related responses. In moulds, such as Aspergillus fumigatus, QSM and sphingolipids are important for maintaining cell wall integrity and virulence. Finally, fungal cells make oxylipins to increase their virulence attributes and to counteract the host immune defences. In this review, we discuss these aspects in details.</description><subject>Aspergillus fumigatus</subject><subject>Aspergillus fumigatus - metabolism</subject><subject>Aspergillus fumigatus - pathogenicity</subject><subject>Biofilms</subject><subject>Candida albicans</subject><subject>Candida albicans - metabolism</subject><subject>Candida albicans - pathogenicity</subject><subject>Cell walls</subject><subject>Cryptococcus neoformans</subject><subject>Cryptococcus neoformans - metabolism</subject><subject>Cryptococcus neoformans - pathogenicity</subject><subject>Enzymes</subject><subject>Farnesol</subject><subject>Fungi</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Mammalian cells</subject><subject>Mycelia</subject><subject>Pathogenicity</subject><subject>Quorum Sensing</subject><subject>Signal Transduction</subject><subject>Sphingolipids</subject><subject>Stress</subject><subject>Virulence</subject><subject>virulence factors</subject><subject>Virulence Factors - metabolism</subject><issn>1462-5814</issn><issn>1462-5822</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctOwzAQRS0E4lH4BYgQEquWGTtO4gVIqOIlFbEA1iPHdYKrNClJA-XvcWipgA3eeOR75mo8l7EAYYD-nE0GGEa8LxPOBxz8K6CUMFhssN21sLmuMdxhe00zAcAoRtxmOxxBoeJyl52M3MyNg8blpS4KV-aBK4OZnr9UuS2dCbK2zN0-28p00diD1d1jz9dXT8Pb_ujh5m54OeobCTH0RQqpFZBialKpogwMxCGgsZE1YCOps4gnqFMdmURamyobimgca6WMTKQWosculr6zNp3asbHlvNYFzWo31fUHVdrRb6V0L5RXbyQx9M7KG5yuDOrqtbXNnKauMbYodGmrtqFEKRRSIfxPhiDCWEHnefyHnFRt7bflIaE4Kgmhhw5_Tr4e-XvRHjhfAu-usB9rHYG6QGlCXVbU5UZdoPQVKC1oeH_XVb7_aNmf6Yp0XruGnh89KcB_G2POxScyPJuV</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Singh, Arpita</creator><creator>Del Poeta, Maurizio</creator><general>Blackwell Publishing Ltd</general><general>Hindawi Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201102</creationdate><title>Lipid signalling in pathogenic fungi</title><author>Singh, Arpita ; Del Poeta, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5070-3b0be30b1bcb596f0c07401ce6ec0e65af6281aba6c85eeb9e436d7a99c585a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aspergillus fumigatus</topic><topic>Aspergillus fumigatus - metabolism</topic><topic>Aspergillus fumigatus - pathogenicity</topic><topic>Biofilms</topic><topic>Candida albicans</topic><topic>Candida albicans - metabolism</topic><topic>Candida albicans - pathogenicity</topic><topic>Cell walls</topic><topic>Cryptococcus neoformans</topic><topic>Cryptococcus neoformans - metabolism</topic><topic>Cryptococcus neoformans - pathogenicity</topic><topic>Enzymes</topic><topic>Farnesol</topic><topic>Fungi</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Mammalian cells</topic><topic>Mycelia</topic><topic>Pathogenicity</topic><topic>Quorum Sensing</topic><topic>Signal Transduction</topic><topic>Sphingolipids</topic><topic>Stress</topic><topic>Virulence</topic><topic>virulence factors</topic><topic>Virulence Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Arpita</creatorcontrib><creatorcontrib>Del Poeta, Maurizio</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Arpita</au><au>Del Poeta, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid signalling in pathogenic fungi</atitle><jtitle>Cellular microbiology</jtitle><addtitle>Cell Microbiol</addtitle><date>2011-02</date><risdate>2011</risdate><volume>13</volume><issue>2</issue><spage>177</spage><epage>185</epage><pages>177-185</pages><issn>1462-5814</issn><eissn>1462-5822</eissn><abstract>In recent years, the study of lipid signalling networks has significantly increased. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Aspergillus fumigatus Aspergillus fumigatus - metabolism Aspergillus fumigatus - pathogenicity Biofilms Candida albicans Candida albicans - metabolism Candida albicans - pathogenicity Cell walls Cryptococcus neoformans Cryptococcus neoformans - metabolism Cryptococcus neoformans - pathogenicity Enzymes Farnesol Fungi Lipid Metabolism Lipids Mammalian cells Mycelia Pathogenicity Quorum Sensing Signal Transduction Sphingolipids Stress Virulence virulence factors Virulence Factors - metabolism |
| title | Lipid signalling in pathogenic fungi |
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