Melastoma malabathricum Linn attenuates complete freund's adjuvant-induced chronic inflammation in Wistar rats via inflammation response
Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as "putki," has a broad range of health benefits, for its free radical scavenging constit...
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| Veröffentlicht in: | BMC complementary and alternative medicine 2016-12, Vol.16 (1), p.510 |
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| creator | Kumar, Vikas Bhatt, Prakash Chandra Rahman, Mahfoozur Patel, Dinesh Kumar Sethi, Nikunj Kumar, Atul Sachan, Nikhil Kumar Kaithwas, Gaurav Al-Abbasi, F A Anwar, Firoz Verma, Amita |
| description | Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as "putki," has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of MM against adjuvant-induced arthritis in experimental rats.
High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract. Protective effect of MM extract in Wistar rats was estimated using CFA-induced model. The rats were divided into different groups with six rats in each group. All animals received oral administration of MM and indomethacin for 28 days. The body weight and arthritic score were scrutinized at regular intervals. At the end of experimental protocol, the rats were sacrificed, and blood samples were used for antioxidant, hematological parameters, pro-inflammatory and inflammatory mediator, respectively. Histopathological observation was used to evaluate the protective effect of MM extract.
Current study confirmed the preventive effect of MM against adjuvant-induced paw edema, paw redness and arthritic progression. MM significantly (P |
| doi_str_mv | 10.1186/s12906-016-1470-9 |
| format | Article |
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High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract. Protective effect of MM extract in Wistar rats was estimated using CFA-induced model. The rats were divided into different groups with six rats in each group. All animals received oral administration of MM and indomethacin for 28 days. The body weight and arthritic score were scrutinized at regular intervals. At the end of experimental protocol, the rats were sacrificed, and blood samples were used for antioxidant, hematological parameters, pro-inflammatory and inflammatory mediator, respectively. Histopathological observation was used to evaluate the protective effect of MM extract.
Current study confirmed the preventive effect of MM against adjuvant-induced paw edema, paw redness and arthritic progression. MM significantly (P < 0.001) modulated the oxidative stress parameters as well as hematological parameter induced by CFA. The result also altered the distorted level of proinflammatory mediators and inflammatory mediator, which further reinforce the implication of MM in CFA induced arthritis. Histological analyses of joints of rats showed a reduction in the synovial hyperplasia and mononuclear infiltration in the MM treated group which provides evidence for the antiarthritic effect of MM.
From above parameters our study states that the MM is capable of restraining the alteration produced via adjuvant-induced arthritis in aminals. The repressing effect of MM could be attributed, at least in part, to antioxidant, hematological and anti-inflammatory effect. Figure Caption: Melastoma Malabathricum Linn Attenuates Complete Freund's Adjuvant-Induced Chronic Inflammation in Wistar rats by Inflammation Response.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/s12906-016-1470-9</identifier><identifier>PMID: 27927194</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Anti-inflammatory drugs ; Antioxidants ; Antioxidants - metabolism ; Arthritis ; Arthritis - blood ; Arthritis - chemically induced ; Arthritis - drug therapy ; Arthritis - pathology ; Care and treatment ; Cartilage, Articular - pathology ; Cellulose ; Chromatography ; Deoxyribonucleic acid ; DNA ; Drug Evaluation, Preclinical ; Enzymes ; Female ; Freund's Adjuvant ; Funding ; Inflammation ; Inflammation - blood ; Inflammation - chemically induced ; Inflammation - drug therapy ; Lipoproteins ; Male ; Melastomataceae ; Molecular Docking Simulation ; Nonsteroidal anti-inflammatory drugs ; Phytotherapy ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Plant Extracts - toxicity ; Proteins ; Quercetin - analysis ; Random Allocation ; Rats, Wistar ; Researchers ; Rheumatoid arthritis ; Risk factors ; Rodents ; Studies ; Tumor necrosis factor-TNF</subject><ispartof>BMC complementary and alternative medicine, 2016-12, Vol.16 (1), p.510</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142378/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142378/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27927194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Vikas</creatorcontrib><creatorcontrib>Bhatt, Prakash Chandra</creatorcontrib><creatorcontrib>Rahman, Mahfoozur</creatorcontrib><creatorcontrib>Patel, Dinesh Kumar</creatorcontrib><creatorcontrib>Sethi, Nikunj</creatorcontrib><creatorcontrib>Kumar, Atul</creatorcontrib><creatorcontrib>Sachan, Nikhil Kumar</creatorcontrib><creatorcontrib>Kaithwas, Gaurav</creatorcontrib><creatorcontrib>Al-Abbasi, F A</creatorcontrib><creatorcontrib>Anwar, Firoz</creatorcontrib><creatorcontrib>Verma, Amita</creatorcontrib><title>Melastoma malabathricum Linn attenuates complete freund's adjuvant-induced chronic inflammation in Wistar rats via inflammation response</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as "putki," has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of MM against adjuvant-induced arthritis in experimental rats.
High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract. Protective effect of MM extract in Wistar rats was estimated using CFA-induced model. The rats were divided into different groups with six rats in each group. All animals received oral administration of MM and indomethacin for 28 days. The body weight and arthritic score were scrutinized at regular intervals. At the end of experimental protocol, the rats were sacrificed, and blood samples were used for antioxidant, hematological parameters, pro-inflammatory and inflammatory mediator, respectively. Histopathological observation was used to evaluate the protective effect of MM extract.
Current study confirmed the preventive effect of MM against adjuvant-induced paw edema, paw redness and arthritic progression. MM significantly (P < 0.001) modulated the oxidative stress parameters as well as hematological parameter induced by CFA. The result also altered the distorted level of proinflammatory mediators and inflammatory mediator, which further reinforce the implication of MM in CFA induced arthritis. Histological analyses of joints of rats showed a reduction in the synovial hyperplasia and mononuclear infiltration in the MM treated group which provides evidence for the antiarthritic effect of MM.
From above parameters our study states that the MM is capable of restraining the alteration produced via adjuvant-induced arthritis in aminals. The repressing effect of MM could be attributed, at least in part, to antioxidant, hematological and anti-inflammatory effect. Figure Caption: Melastoma Malabathricum Linn Attenuates Complete Freund's Adjuvant-Induced Chronic Inflammation in Wistar rats by Inflammation Response.</description><subject>Animals</subject><subject>Anti-inflammatory drugs</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Arthritis</subject><subject>Arthritis - blood</subject><subject>Arthritis - chemically induced</subject><subject>Arthritis - drug therapy</subject><subject>Arthritis - pathology</subject><subject>Care and treatment</subject><subject>Cartilage, Articular - pathology</subject><subject>Cellulose</subject><subject>Chromatography</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug Evaluation, Preclinical</subject><subject>Enzymes</subject><subject>Female</subject><subject>Freund's Adjuvant</subject><subject>Funding</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Melastomataceae</subject><subject>Molecular Docking Simulation</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Phytotherapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Extracts - toxicity</subject><subject>Proteins</subject><subject>Quercetin - analysis</subject><subject>Random Allocation</subject><subject>Rats, Wistar</subject><subject>Researchers</subject><subject>Rheumatoid arthritis</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Studies</subject><subject>Tumor necrosis factor-TNF</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUcmKFEEQLURxFv0AL5Ig6KnGzKz9IgyDjkKLF8VjEpUZ1ZVNLm0uDfMHfrY5OGo3SBxie_GIF1FVLxi9Ymzs30bGJ9rXlPU1awdaT4-q8xLwuh9H_vgoPqsuYtxRyoaRtU-rMz5MfGBTe179_IwGYvIWiAUDM6Q1aJkt2WjnCKSELkPCSKS3e4MJyRIwO_UmElC7fACXau1UlqiIXIN3WhLtFgPWQtLelYR81zFBIAFSJAcNp_2Ace9dxGfVkwVMxOcP_rL69uH915uP9ebL7aeb6029bSae6qVl9F7RoiTjPWugZ72CTgKFeVJsWOZmbhbJ26VVYzdgN9Fx5lxRrnrZTNhcVu9-8-7zbFFJdCmAEfugLYQ74UGL047Tq9j6g-hYy5thLASvHgiC_5ExJrHzObiys2Bj13blxNPwD7UFg6Io9oVMWh2luG6Hho2M876grv6DKqbQaukdLrrUTwZeHw2sCCat0Zt8f8p4Cnx5LPOvvj-fb34BDmGy0A</recordid><startdate>20161207</startdate><enddate>20161207</enddate><creator>Kumar, Vikas</creator><creator>Bhatt, Prakash Chandra</creator><creator>Rahman, Mahfoozur</creator><creator>Patel, Dinesh Kumar</creator><creator>Sethi, Nikunj</creator><creator>Kumar, Atul</creator><creator>Sachan, Nikhil Kumar</creator><creator>Kaithwas, Gaurav</creator><creator>Al-Abbasi, F A</creator><creator>Anwar, Firoz</creator><creator>Verma, Amita</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20161207</creationdate><title>Melastoma malabathricum Linn attenuates complete freund's adjuvant-induced chronic inflammation in Wistar rats via inflammation response</title><author>Kumar, Vikas ; Bhatt, Prakash Chandra ; Rahman, Mahfoozur ; Patel, Dinesh Kumar ; Sethi, Nikunj ; Kumar, Atul ; Sachan, Nikhil Kumar ; Kaithwas, Gaurav ; Al-Abbasi, F A ; Anwar, Firoz ; Verma, Amita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g392t-f4106882fdc12613a616da5ca0ab9d17fb3b3fc24f4d857e5908b22d02d6c39e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anti-inflammatory drugs</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Arthritis</topic><topic>Arthritis - blood</topic><topic>Arthritis - chemically induced</topic><topic>Arthritis - drug therapy</topic><topic>Arthritis - pathology</topic><topic>Care and treatment</topic><topic>Cartilage, Articular - pathology</topic><topic>Cellulose</topic><topic>Chromatography</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug Evaluation, Preclinical</topic><topic>Enzymes</topic><topic>Female</topic><topic>Freund's Adjuvant</topic><topic>Funding</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Melastomataceae</topic><topic>Molecular Docking Simulation</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Phytotherapy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Extracts - toxicity</topic><topic>Proteins</topic><topic>Quercetin - analysis</topic><topic>Random Allocation</topic><topic>Rats, Wistar</topic><topic>Researchers</topic><topic>Rheumatoid arthritis</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Studies</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Vikas</creatorcontrib><creatorcontrib>Bhatt, Prakash Chandra</creatorcontrib><creatorcontrib>Rahman, Mahfoozur</creatorcontrib><creatorcontrib>Patel, Dinesh Kumar</creatorcontrib><creatorcontrib>Sethi, Nikunj</creatorcontrib><creatorcontrib>Kumar, Atul</creatorcontrib><creatorcontrib>Sachan, Nikhil Kumar</creatorcontrib><creatorcontrib>Kaithwas, Gaurav</creatorcontrib><creatorcontrib>Al-Abbasi, F A</creatorcontrib><creatorcontrib>Anwar, Firoz</creatorcontrib><creatorcontrib>Verma, Amita</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Vikas</au><au>Bhatt, Prakash Chandra</au><au>Rahman, Mahfoozur</au><au>Patel, Dinesh Kumar</au><au>Sethi, Nikunj</au><au>Kumar, Atul</au><au>Sachan, Nikhil Kumar</au><au>Kaithwas, Gaurav</au><au>Al-Abbasi, F A</au><au>Anwar, Firoz</au><au>Verma, Amita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melastoma malabathricum Linn attenuates complete freund's adjuvant-induced chronic inflammation in Wistar rats via inflammation response</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Altern Med</addtitle><date>2016-12-07</date><risdate>2016</risdate><volume>16</volume><issue>1</issue><spage>510</spage><pages>510-</pages><issn>1472-6882</issn><eissn>1472-6882</eissn><abstract>Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as "putki," has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of MM against adjuvant-induced arthritis in experimental rats.
High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract. Protective effect of MM extract in Wistar rats was estimated using CFA-induced model. The rats were divided into different groups with six rats in each group. All animals received oral administration of MM and indomethacin for 28 days. The body weight and arthritic score were scrutinized at regular intervals. At the end of experimental protocol, the rats were sacrificed, and blood samples were used for antioxidant, hematological parameters, pro-inflammatory and inflammatory mediator, respectively. Histopathological observation was used to evaluate the protective effect of MM extract.
Current study confirmed the preventive effect of MM against adjuvant-induced paw edema, paw redness and arthritic progression. MM significantly (P < 0.001) modulated the oxidative stress parameters as well as hematological parameter induced by CFA. The result also altered the distorted level of proinflammatory mediators and inflammatory mediator, which further reinforce the implication of MM in CFA induced arthritis. Histological analyses of joints of rats showed a reduction in the synovial hyperplasia and mononuclear infiltration in the MM treated group which provides evidence for the antiarthritic effect of MM.
From above parameters our study states that the MM is capable of restraining the alteration produced via adjuvant-induced arthritis in aminals. The repressing effect of MM could be attributed, at least in part, to antioxidant, hematological and anti-inflammatory effect. Figure Caption: Melastoma Malabathricum Linn Attenuates Complete Freund's Adjuvant-Induced Chronic Inflammation in Wistar rats by Inflammation Response.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27927194</pmid><doi>10.1186/s12906-016-1470-9</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-inflammatory drugs Antioxidants Antioxidants - metabolism Arthritis Arthritis - blood Arthritis - chemically induced Arthritis - drug therapy Arthritis - pathology Care and treatment Cartilage, Articular - pathology Cellulose Chromatography Deoxyribonucleic acid DNA Drug Evaluation, Preclinical Enzymes Female Freund's Adjuvant Funding Inflammation Inflammation - blood Inflammation - chemically induced Inflammation - drug therapy Lipoproteins Male Melastomataceae Molecular Docking Simulation Nonsteroidal anti-inflammatory drugs Phytotherapy Plant Extracts - chemistry Plant Extracts - therapeutic use Plant Extracts - toxicity Proteins Quercetin - analysis Random Allocation Rats, Wistar Researchers Rheumatoid arthritis Risk factors Rodents Studies Tumor necrosis factor-TNF |
| title | Melastoma malabathricum Linn attenuates complete freund's adjuvant-induced chronic inflammation in Wistar rats via inflammation response |
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