Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains
During the 2013–2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutinationinhibition (HAI) assays, using sera collected from 382 individuals pri...
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| Veröffentlicht in: | The Journal of infectious diseases 2016-12, Vol.214 (12), p.1947-1951 |
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| container_end_page | 1951 |
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| container_issue | 12 |
| container_start_page | 1947 |
| container_title | The Journal of infectious diseases |
| container_volume | 214 |
| creator | Petrie, Joshua G. Parkhouse, Kaela Ohmit, Suzanne E. Malosh, Ryan E. Monto, Arnold S. Hensley, Scott E. |
| description | During the 2013–2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutinationinhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013–2014 season, and we determined whether HAI titers were associated with protection from A(H1N1) pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1) pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain. |
| doi_str_mv | 10.1093/infdis/jiw479 |
| format | Article |
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Here, we performed hemagglutinationinhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013–2014 season, and we determined whether HAI titers were associated with protection from A(H1N1) pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1) pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain.</description><identifier>ISSN: 0022-1899</identifier><identifier>ISSN: 1537-6613</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiw479</identifier><identifier>PMID: 27923954</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies, Viral - blood ; Cross Protection ; Female ; Hemagglutination Inhibition Tests ; Humans ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Influenza, Human - virology ; Major and Brief Reports ; Male ; Middle Aged ; VIRUSES ; Young Adult</subject><ispartof>The Journal of infectious diseases, 2016-12, Vol.214 (12), p.1947-1951</ispartof><rights>Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.</rights><rights>The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-33f07acca2eb13c18b8a69d815494aac43dbc26335ab7cef26e77c7e12f155b93</citedby><cites>FETCH-LOGICAL-c409t-33f07acca2eb13c18b8a69d815494aac43dbc26335ab7cef26e77c7e12f155b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26166619$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26166619$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27923954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrie, Joshua G.</creatorcontrib><creatorcontrib>Parkhouse, Kaela</creatorcontrib><creatorcontrib>Ohmit, Suzanne E.</creatorcontrib><creatorcontrib>Malosh, Ryan E.</creatorcontrib><creatorcontrib>Monto, Arnold S.</creatorcontrib><creatorcontrib>Hensley, Scott E.</creatorcontrib><title>Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>During the 2013–2014 influenza season, nearly all circulating 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) strains possessed an antigenically important mutation in hemagglutinin (K166Q). Here, we performed hemagglutinationinhibition (HAI) assays, using sera collected from 382 individuals prior to the 2013–2014 season, and we determined whether HAI titers were associated with protection from A(H1N1) pdm09 infection. Protection was associated with HAI titers against an A(H1N1)pdm09 strain possessing the K166Q mutation but not with HAI titers against the current A(H1N1) pdm09 vaccine strain, which lacks this mutation. These data indicate that contemporary A(H1N1)pdm09 strains are antigenically distinct from the current A(H1N1)pdm09 vaccine strain.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Viral - blood</subject><subject>Cross Protection</subject><subject>Female</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Humans</subject><subject>Influenza A Virus, H1N1 Subtype - immunology</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - prevention & control</subject><subject>Influenza, Human - virology</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Middle Aged</subject><subject>VIRUSES</subject><subject>Young Adult</subject><issn>0022-1899</issn><issn>1537-6613</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkktv1DAAhC0EokvhyBHkYzmE-hU7viCtAqWVqoJUHkfLcZxdrxJ7aztF8Jv4kbjKUkDi5MN8nhl5DMBzjF5jJOmp80Pv0unOfWNCPgArXFNRcY7pQ7BCiJAKN1IegScp7RBCjHLxGBwRIQmVNVuBn2ufXRd6ZxNcb7TzKcO8tbCdY7Q-wws_jLP1PzRcn5zjK_wKftHGOG_hdY4Fh28DvAoZfowhW5PhdZhsudS7W9fPekzwLIbpzqWILnj41eUtbIPPdtqHqON32Lpo5lFn5zf_S3NxToes9BQ8GoqnfXY4j8Hns3ef2vPq8sP7i3Z9WRmGZK4oHZAoLTWxHaYGN12juewbXDPJtDaM9p0hnNJad8LYgXArhBEWkwHXdSfpMXiz-O7nbrK9KQ8R9aj20U2lsQraqX8V77ZqE25VjRkpoxSDk4NBDDezTVlNLhk7jtrbMCeFG8YFljUSBa0W1MSQUrTDfQxG6m5htSysloUL__Lvbvf070kL8GIBdimH-EfnmJdvIekvjeWw4w</recordid><startdate>20161215</startdate><enddate>20161215</enddate><creator>Petrie, Joshua G.</creator><creator>Parkhouse, Kaela</creator><creator>Ohmit, Suzanne E.</creator><creator>Malosh, Ryan E.</creator><creator>Monto, Arnold S.</creator><creator>Hensley, Scott E.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161215</creationdate><title>Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains</title><author>Petrie, Joshua G. ; 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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Antibodies, Viral - blood Cross Protection Female Hemagglutination Inhibition Tests Humans Influenza A Virus, H1N1 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology Major and Brief Reports Male Middle Aged VIRUSES Young Adult |
| title | Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains |
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