Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

Analysis of T cells isolated from patients with and without type 1 diabetes reveals reactivity to a range of native as well as post-translationally modified self-antigens only in individuals with T1D. A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T...

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Veröffentlicht in:	Nature medicine 2016-12, Vol.22 (12), p.1482-1487
Hauptverfasser:	Babon, Jenny Aurielle B, DeNicola, Megan E, Blodgett, David M, Crèvecoeur, Inne, Buttrick, Thomas S, Maehr, René, Bottino, Rita, Naji, Ali, Kaddis, John, Elyaman, Wassim, James, Eddie A, Haliyur, Rachana, Brissova, Marcela, Overbergh, Lut, Mathieu, Chantal, Delong, Thomas, Haskins, Kathryn, Pugliese, Alberto, Campbell-Thompson, Martha, Mathews, Clayton, Atkinson, Mark A, Powers, Alvin C, Harlan, David M, Kent, Sally C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/1775 631/250/38 692/699/249/1313/1418 Adolescent Adult Analysis Antigens Autoantigens - immunology Autoimmunity - immunology Biomedicine Cancer Research CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Child Diabetes Diabetes Mellitus, Type 1 - immunology Female HLA-A2 Antigen - immunology HLA-DQ Antigens - immunology Humans Immunotherapy Infectious Diseases Islets of Langerhans - immunology letter Male Metabolic Diseases Molecular Medicine Neurosciences Peptides T cells T-Lymphocytes - immunology Type 1 diabetes Young Adult
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