Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with Gi-DREADD in mice

Background Exercise alleviates pain and it is a central component of treatment strategy for chronic pain in clinical setting. However, little is known about mechanism of this exercise-induced hypoalgesia. The mesolimbic dopaminergic network plays a role in positive emotions to rewards including moti...

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Veröffentlicht in:	Molecular pain 2016-11, Vol.12
Hauptverfasser:	Wakaizumi, Kenta, Kondo, Takashige, Hamada, Yusuke, Narita, Michiko, Kawabe, Rui, Narita, Hiroki, Watanabe, Moe, Kato, Shigeki, Senba, Emiko, Kobayashi, Kazuto, Kuzumaki, Naoko, Yamanaka, Akihiro, Morisaki, Hiroshi, Narita, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clozapine - analogs & derivatives Clozapine - pharmacology Disease Models, Animal Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Exercise Test Exercise Therapy - methods Hyperalgesia - etiology Hyperalgesia - rehabilitation Mice Mice, Inbred C57BL Mice, Transgenic Neuralgia - pathology Neuralgia - rehabilitation Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Pain Measurement Pain Threshold - physiology Phosphopyruvate Hydratase - genetics Phosphopyruvate Hydratase - metabolism Receptors, G-Protein-Coupled - metabolism Serotonin Antagonists - pharmacology Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism Ventral Tegmental Area - physiopathology
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