Antimicrobial activity and safety evaluation of peptides isolated from the hemoglobin of chickens
Hemoglobin is a rich source of biological peptides. As a byproduct and even wastewater of poultry-slaughtering facilities, chicken blood is one of the most abundant source of hemoglobin. In this study, the chicken hemoglobin antimicrobial peptides (CHAP) were isolated and the antimicrobial and bacte...
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| Veröffentlicht in: | BMC microbiology 2016-12, Vol.16 (1), p.287-287, Article 287 |
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| creator | Hu, Fengjiao Wu, Qiaoxing Song, Shuang She, Ruiping Zhao, Yue Yang, Yifei Zhang, Meikun Du, Fang Soomro, Majid Hussain Shi, Ruihan |
| description | Hemoglobin is a rich source of biological peptides. As a byproduct and even wastewater of poultry-slaughtering facilities, chicken blood is one of the most abundant source of hemoglobin.
In this study, the chicken hemoglobin antimicrobial peptides (CHAP) were isolated and the antimicrobial and bactericidal activities were tested by the agarose diffusion assay, minimum inhibitory concentration (MIC) analysis, minimal bactericidal concentration (MBC) analysis, and time-dependent inhibitory and bactericidal assays. The results demonstrated that CHAP had potent and rapid antimicrobial activity against 19 bacterial strains, including 9 multidrug-resistant bacterial strains. Bacterial biofilm and NaCl permeability assays, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were further performed to detect the mechanism of its antimicrobial effect. Additionally, CHAP showed low hemolytic activity, embryo toxicity, and high stability in different temperatures and animal plasma.
CHAP may have great potential for expanding production and development value in animal medication, the breeding industry and environment protection. |
| doi_str_mv | 10.1186/s12866-016-0904-3 |
| format | Article |
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In this study, the chicken hemoglobin antimicrobial peptides (CHAP) were isolated and the antimicrobial and bactericidal activities were tested by the agarose diffusion assay, minimum inhibitory concentration (MIC) analysis, minimal bactericidal concentration (MBC) analysis, and time-dependent inhibitory and bactericidal assays. The results demonstrated that CHAP had potent and rapid antimicrobial activity against 19 bacterial strains, including 9 multidrug-resistant bacterial strains. Bacterial biofilm and NaCl permeability assays, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were further performed to detect the mechanism of its antimicrobial effect. Additionally, CHAP showed low hemolytic activity, embryo toxicity, and high stability in different temperatures and animal plasma.
CHAP may have great potential for expanding production and development value in animal medication, the breeding industry and environment protection.</description><identifier>ISSN: 1471-2180</identifier><identifier>EISSN: 1471-2180</identifier><identifier>DOI: 10.1186/s12866-016-0904-3</identifier><identifier>PMID: 27919228</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject><![CDATA[Analysis ; Animals ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Anti-infective agents ; Anti-Infective Agents - isolation & purification ; Anti-Infective Agents - pharmacology ; Antibiotics ; Antimicrobial agents ; Antimicrobial Cationic Peptides - isolation & purification ; Antimicrobial Cationic Peptides - pharmacology ; Bacteria ; Bacteria - drug effects ; Bacteria - growth & development ; Bacteriolysis - drug effects ; Biofilms - drug effects ; Biofilms - growth & development ; Blood Bactericidal Activity ; Cell Membrane Permeability - drug effects ; Chickens ; Drug resistance in microorganisms ; Drug Resistance, Multiple, Bacterial ; E coli ; Gram-positive bacteria ; Health aspects ; Hemoglobin ; Hemoglobins - chemistry ; Hemoglobins - pharmacology ; Hemolytic Agents - isolation & purification ; Hemolytic Agents - pharmacology ; Laboratories ; Microbial Sensitivity Tests ; Microscopy, Electron, Scanning ; Microscopy, Electron, Transmission ; Peptide Fragments - chemistry ; Peptide Fragments - pharmacology ; Peptides ; Poultry ; Protein Stability ; Sodium ; Sodium Chloride - metabolism ; Veterinary colleges ; Veterinary medicine]]></subject><ispartof>BMC microbiology, 2016-12, Vol.16 (1), p.287-287, Article 287</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-fc499b358bb7c895e0d1e677b3bb84326c607f58aefcc4ef11433c9ee05b5a73</citedby><cites>FETCH-LOGICAL-c528t-fc499b358bb7c895e0d1e677b3bb84326c607f58aefcc4ef11433c9ee05b5a73</cites><orcidid>0000-0002-7604-1680</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139128/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139128/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27919228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Fengjiao</creatorcontrib><creatorcontrib>Wu, Qiaoxing</creatorcontrib><creatorcontrib>Song, Shuang</creatorcontrib><creatorcontrib>She, Ruiping</creatorcontrib><creatorcontrib>Zhao, Yue</creatorcontrib><creatorcontrib>Yang, Yifei</creatorcontrib><creatorcontrib>Zhang, Meikun</creatorcontrib><creatorcontrib>Du, Fang</creatorcontrib><creatorcontrib>Soomro, Majid Hussain</creatorcontrib><creatorcontrib>Shi, Ruihan</creatorcontrib><title>Antimicrobial activity and safety evaluation of peptides isolated from the hemoglobin of chickens</title><title>BMC microbiology</title><addtitle>BMC Microbiol</addtitle><description>Hemoglobin is a rich source of biological peptides. As a byproduct and even wastewater of poultry-slaughtering facilities, chicken blood is one of the most abundant source of hemoglobin.
In this study, the chicken hemoglobin antimicrobial peptides (CHAP) were isolated and the antimicrobial and bactericidal activities were tested by the agarose diffusion assay, minimum inhibitory concentration (MIC) analysis, minimal bactericidal concentration (MBC) analysis, and time-dependent inhibitory and bactericidal assays. The results demonstrated that CHAP had potent and rapid antimicrobial activity against 19 bacterial strains, including 9 multidrug-resistant bacterial strains. Bacterial biofilm and NaCl permeability assays, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were further performed to detect the mechanism of its antimicrobial effect. Additionally, CHAP showed low hemolytic activity, embryo toxicity, and high stability in different temperatures and animal plasma.
CHAP may have great potential for expanding production and development value in animal medication, the breeding industry and environment protection.</description><subject>Analysis</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-infective agents</subject><subject>Anti-Infective Agents - isolation & purification</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial Cationic Peptides - isolation & purification</subject><subject>Antimicrobial Cationic Peptides - pharmacology</subject><subject>Bacteria</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - growth & development</subject><subject>Bacteriolysis - drug effects</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Blood Bactericidal Activity</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Chickens</subject><subject>Drug resistance in microorganisms</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>E coli</subject><subject>Gram-positive bacteria</subject><subject>Health aspects</subject><subject>Hemoglobin</subject><subject>Hemoglobins - chemistry</subject><subject>Hemoglobins - pharmacology</subject><subject>Hemolytic Agents - isolation & purification</subject><subject>Hemolytic Agents - pharmacology</subject><subject>Laboratories</subject><subject>Microbial Sensitivity Tests</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microscopy, Electron, Transmission</subject><subject>Peptide Fragments - chemistry</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptides</subject><subject>Poultry</subject><subject>Protein Stability</subject><subject>Sodium</subject><subject>Sodium Chloride - metabolism</subject><subject>Veterinary colleges</subject><subject>Veterinary medicine</subject><issn>1471-2180</issn><issn>1471-2180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkl1rFDEUhgdR7If-AG9kwBt7MTWZfM6NsJRWC4VC7X3IZE52UzPJOsks7b8369ayKxJCDslz3kPOeavqA0bnGEv-JeFWct4gXHaHaENeVceYCty0WKLXe_FRdZLSA0JYSCLeVket6HDXtvK40ouQ3ejMFHunfa1NdhuXn2odhjppCyWEjfazzi6GOtp6DevsBki1S9HrDENtpzjWeQX1Csa49EXoD2hWzvyEkN5Vb6z2Cd4_n6fV_dXl_cX35ub22_XF4qYxrJW5sYZ2XU-Y7HthZMcADRi4ED3pe0lJyw1HwjKpwRpDwWJMCTEdAGI904KcVl93suu5H2EwEPKkvVpPbtTTk4raqcOX4FZqGTeKYdKVPhaBz88CU_w1Q8pqdMmA9zpAnJPCknLCOWZtQT_9gz7EeQrld4ViVFAm-R611B6UCzaWumYrqhZUlMm1Em3Lnv-HKmuAMpYYwLpyf5BwdpBQmAyPeannlNT1j7tDFu_YMt-UJrAv_cBIbS2kdhZSxUJqayFFSs7H_Ua-ZPz1DPkNq4fBjA</recordid><startdate>20161205</startdate><enddate>20161205</enddate><creator>Hu, Fengjiao</creator><creator>Wu, Qiaoxing</creator><creator>Song, Shuang</creator><creator>She, Ruiping</creator><creator>Zhao, Yue</creator><creator>Yang, Yifei</creator><creator>Zhang, Meikun</creator><creator>Du, Fang</creator><creator>Soomro, Majid Hussain</creator><creator>Shi, Ruihan</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7604-1680</orcidid></search><sort><creationdate>20161205</creationdate><title>Antimicrobial activity and safety evaluation of peptides isolated from the hemoglobin of chickens</title><author>Hu, Fengjiao ; Wu, Qiaoxing ; Song, Shuang ; She, Ruiping ; Zhao, Yue ; Yang, Yifei ; Zhang, Meikun ; Du, Fang ; Soomro, Majid Hussain ; Shi, Ruihan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-fc499b358bb7c895e0d1e677b3bb84326c607f58aefcc4ef11433c9ee05b5a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Fengjiao</au><au>Wu, Qiaoxing</au><au>Song, Shuang</au><au>She, Ruiping</au><au>Zhao, Yue</au><au>Yang, Yifei</au><au>Zhang, Meikun</au><au>Du, Fang</au><au>Soomro, Majid Hussain</au><au>Shi, Ruihan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial activity and safety evaluation of peptides isolated from the hemoglobin of chickens</atitle><jtitle>BMC microbiology</jtitle><addtitle>BMC Microbiol</addtitle><date>2016-12-05</date><risdate>2016</risdate><volume>16</volume><issue>1</issue><spage>287</spage><epage>287</epage><pages>287-287</pages><artnum>287</artnum><issn>1471-2180</issn><eissn>1471-2180</eissn><abstract>Hemoglobin is a rich source of biological peptides. As a byproduct and even wastewater of poultry-slaughtering facilities, chicken blood is one of the most abundant source of hemoglobin.
In this study, the chicken hemoglobin antimicrobial peptides (CHAP) were isolated and the antimicrobial and bactericidal activities were tested by the agarose diffusion assay, minimum inhibitory concentration (MIC) analysis, minimal bactericidal concentration (MBC) analysis, and time-dependent inhibitory and bactericidal assays. The results demonstrated that CHAP had potent and rapid antimicrobial activity against 19 bacterial strains, including 9 multidrug-resistant bacterial strains. Bacterial biofilm and NaCl permeability assays, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were further performed to detect the mechanism of its antimicrobial effect. Additionally, CHAP showed low hemolytic activity, embryo toxicity, and high stability in different temperatures and animal plasma.
CHAP may have great potential for expanding production and development value in animal medication, the breeding industry and environment protection.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27919228</pmid><doi>10.1186/s12866-016-0904-3</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7604-1680</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animals Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Anti-infective agents Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antibiotics Antimicrobial agents Antimicrobial Cationic Peptides - isolation & purification Antimicrobial Cationic Peptides - pharmacology Bacteria Bacteria - drug effects Bacteria - growth & development Bacteriolysis - drug effects Biofilms - drug effects Biofilms - growth & development Blood Bactericidal Activity Cell Membrane Permeability - drug effects Chickens Drug resistance in microorganisms Drug Resistance, Multiple, Bacterial E coli Gram-positive bacteria Health aspects Hemoglobin Hemoglobins - chemistry Hemoglobins - pharmacology Hemolytic Agents - isolation & purification Hemolytic Agents - pharmacology Laboratories Microbial Sensitivity Tests Microscopy, Electron, Scanning Microscopy, Electron, Transmission Peptide Fragments - chemistry Peptide Fragments - pharmacology Peptides Poultry Protein Stability Sodium Sodium Chloride - metabolism Veterinary colleges Veterinary medicine |
| title | Antimicrobial activity and safety evaluation of peptides isolated from the hemoglobin of chickens |
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