Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock

Animal studies and human case reports show promise in using lipid rescue to treat refractory calcium channel antagonist toxicity. However, the majority of research and clinical experience has focused on non-dihydropyridine agents. Thus, we sought to investigate the value of lipid emulsion (ILE) ther...

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Veröffentlicht in:	Journal of medical toxicology 2016-12, Vol.12 (4), p.380-385
Hauptverfasser:	Murphy, Christine M., Williams, Cliff, Quinn, Michael E., Nicholson, Brian, Shoe, Thomas, Beuhler, Michael C., Kerns, William P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biomedical and Life Sciences Biomedicine Blood Glucose - analysis Blood Glucose - drug effects Blood Pressure - drug effects Bradycardia Bradycardia - etiology Calcium Calcium antagonists Calcium channel blockers Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - poisoning Carbon dioxide Case reports Catheters Clinical trials Dihydropyridine Dihydropyridines - administration & dosage Dihydropyridines - poisoning Disease Models, Animal Drug delivery Drug delivery systems Emissions Emulsion polymerization Fat Emulsions, Intravenous - therapeutic use Female Heart Heart Arrest, Induced Hemodynamics Humans Hypotension Infusion Intravenous administration Lipids Livestock Medical instruments Metabolome - drug effects Muscle contraction Myocardial Contraction - drug effects Nifedipine Nifedipine - administration & dosage Nifedipine - poisoning Original Original Article Pharmacology/Toxicology Pilot Projects Rank tests Seizures Shock - chemically induced Shock - therapy Swine Tachycardia Tachycardia - etiology Toxicity Ventilation
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