Functional connectivity during masked and unmasked face emotion processing in bipolar disorder
Abstract Little is known regarding the neural connectivity and correlates during automatic, unconscious face emotion processing in individuals with bipolar disorder (BD). In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming tas...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2016-12, Vol.258, p.1-9 |
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| container_title | Psychiatry research. Neuroimaging |
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| creator | Tseng, Wan-Ling Thomas, Laura A Harkins, Elizabeth Stoddard, Joel Zarate, Carlos A Pine, Daniel S Leibenluft, Ellen Brotman, Melissa A |
| description | Abstract Little is known regarding the neural connectivity and correlates during automatic, unconscious face emotion processing in individuals with bipolar disorder (BD). In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming task with unconsciously perceived and consciously perceived faces (angry, happy, neutral, blank oval). We found that, regardless of awareness level and emotion types, BD patients exhibited diminished functional connectivity between amygdala and ventromedial prefrontal cortex (vmPFC) compared to HV. This connectivity finding is present in the absence of activation differences in amygdala. In addition, in medial frontal gyrus, BD patients displayed greater activation while HV displayed less activation to angry and neutral faces compared to no face. These results suggest that aberrant amygdala-vmPFC connectivity and neural dysfunction in areas implicated in appraisal and expression of emotions (medial frontal gyrus) may be the pathophysiological correlates of emotional processing in BD regardless of awareness level. |
| doi_str_mv | 10.1016/j.pscychresns.2016.10.006 |
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In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming task with unconsciously perceived and consciously perceived faces (angry, happy, neutral, blank oval). We found that, regardless of awareness level and emotion types, BD patients exhibited diminished functional connectivity between amygdala and ventromedial prefrontal cortex (vmPFC) compared to HV. This connectivity finding is present in the absence of activation differences in amygdala. In addition, in medial frontal gyrus, BD patients displayed greater activation while HV displayed less activation to angry and neutral faces compared to no face. These results suggest that aberrant amygdala-vmPFC connectivity and neural dysfunction in areas implicated in appraisal and expression of emotions (medial frontal gyrus) may be the pathophysiological correlates of emotional processing in BD regardless of awareness level.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2016.10.006</identifier><identifier>PMID: 27814457</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adult ; Amygdala - diagnostic imaging ; Amygdala - physiopathology ; Backward masking ; Bipolar disorder ; Bipolar Disorder - diagnostic imaging ; Bipolar Disorder - physiopathology ; Bipolar Disorder - psychology ; Emotions - physiology ; Face emotion processing ; Facial Expression ; Female ; Frontal Lobe - diagnostic imaging ; Frontal Lobe - physiopathology ; Functional connectivity ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Psychiatry ; Radiology ; Young Adult</subject><ispartof>Psychiatry research. Neuroimaging, 2016-12, Vol.258, p.1-9</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-23adffd30133f503ef0040f100dae44bcc9c32ff039e0d9cb82dca6745f7d8633</citedby><cites>FETCH-LOGICAL-c538t-23adffd30133f503ef0040f100dae44bcc9c32ff039e0d9cb82dca6745f7d8633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pscychresns.2016.10.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27814457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tseng, Wan-Ling</creatorcontrib><creatorcontrib>Thomas, Laura A</creatorcontrib><creatorcontrib>Harkins, Elizabeth</creatorcontrib><creatorcontrib>Stoddard, Joel</creatorcontrib><creatorcontrib>Zarate, Carlos A</creatorcontrib><creatorcontrib>Pine, Daniel S</creatorcontrib><creatorcontrib>Leibenluft, Ellen</creatorcontrib><creatorcontrib>Brotman, Melissa A</creatorcontrib><title>Functional connectivity during masked and unmasked face emotion processing in bipolar disorder</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res Neuroimaging</addtitle><description>Abstract Little is known regarding the neural connectivity and correlates during automatic, unconscious face emotion processing in individuals with bipolar disorder (BD). In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming task with unconsciously perceived and consciously perceived faces (angry, happy, neutral, blank oval). We found that, regardless of awareness level and emotion types, BD patients exhibited diminished functional connectivity between amygdala and ventromedial prefrontal cortex (vmPFC) compared to HV. This connectivity finding is present in the absence of activation differences in amygdala. In addition, in medial frontal gyrus, BD patients displayed greater activation while HV displayed less activation to angry and neutral faces compared to no face. These results suggest that aberrant amygdala-vmPFC connectivity and neural dysfunction in areas implicated in appraisal and expression of emotions (medial frontal gyrus) may be the pathophysiological correlates of emotional processing in BD regardless of awareness level.</description><subject>Adult</subject><subject>Amygdala - diagnostic imaging</subject><subject>Amygdala - physiopathology</subject><subject>Backward masking</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnostic imaging</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Bipolar Disorder - psychology</subject><subject>Emotions - physiology</subject><subject>Face emotion processing</subject><subject>Facial Expression</subject><subject>Female</subject><subject>Frontal Lobe - diagnostic imaging</subject><subject>Frontal Lobe - physiopathology</subject><subject>Functional connectivity</subject><subject>Functional Neuroimaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psychiatry</subject><subject>Radiology</subject><subject>Young Adult</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1vEzEQhi0EoqHwF9By47JhbO_npRKKWkCqxAG4Yjnjcet0117sbKT8e7xKqAonTtZ43nnH42cYe8dhzYE3H3brKeER7yMln9YiX-X7NUDzjK1414qyraF5zlbQi7qsetFesFcp7QCE7Br5kl2ItuNVVbcr9vNm9rh3weuhwOA95eDg9sfCzNH5u2LU6YFMob0pZn8OrEYqaAxLWTHFgJTSonW-2LopDDoWxqUQDcXX7IXVQ6I35_OS_bi5_r75XN5-_fRl8_G2xFp2-1JIbaw1EriUtgZJFqACywGMpqraIvYohbUgewLT47YTBnXTVrVtTR5JXrKrk-80b0cySH4f9aCm6EYdjypop_7OeHev7sJB1VzWDSwG788GMfyaKe3V6BLSMGhPYU6Kd7JppegFz9L-JMUYUopkH9twUAsftVNP-KiFz5LKfHLt26fvfKz8AyQLNicB5d86OIoqoSOPZFzMbJQJ7r_aXP3jgoPzDvXwQEdKuzDHDDxPpZJQoL4ti7LsCW8kAK-E_A3oo8Bv</recordid><startdate>20161230</startdate><enddate>20161230</enddate><creator>Tseng, Wan-Ling</creator><creator>Thomas, Laura A</creator><creator>Harkins, Elizabeth</creator><creator>Stoddard, Joel</creator><creator>Zarate, Carlos A</creator><creator>Pine, Daniel S</creator><creator>Leibenluft, Ellen</creator><creator>Brotman, Melissa A</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161230</creationdate><title>Functional connectivity during masked and unmasked face emotion processing in bipolar disorder</title><author>Tseng, Wan-Ling ; Thomas, Laura A ; Harkins, Elizabeth ; Stoddard, Joel ; Zarate, Carlos A ; Pine, Daniel S ; Leibenluft, Ellen ; Brotman, Melissa A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-23adffd30133f503ef0040f100dae44bcc9c32ff039e0d9cb82dca6745f7d8633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Amygdala - diagnostic imaging</topic><topic>Amygdala - physiopathology</topic><topic>Backward masking</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - diagnostic imaging</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Bipolar Disorder - psychology</topic><topic>Emotions - physiology</topic><topic>Face emotion processing</topic><topic>Facial Expression</topic><topic>Female</topic><topic>Frontal Lobe - diagnostic imaging</topic><topic>Frontal Lobe - physiopathology</topic><topic>Functional connectivity</topic><topic>Functional Neuroimaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psychiatry</topic><topic>Radiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tseng, Wan-Ling</creatorcontrib><creatorcontrib>Thomas, Laura A</creatorcontrib><creatorcontrib>Harkins, Elizabeth</creatorcontrib><creatorcontrib>Stoddard, Joel</creatorcontrib><creatorcontrib>Zarate, Carlos A</creatorcontrib><creatorcontrib>Pine, Daniel S</creatorcontrib><creatorcontrib>Leibenluft, Ellen</creatorcontrib><creatorcontrib>Brotman, Melissa A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychiatry research. Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tseng, Wan-Ling</au><au>Thomas, Laura A</au><au>Harkins, Elizabeth</au><au>Stoddard, Joel</au><au>Zarate, Carlos A</au><au>Pine, Daniel S</au><au>Leibenluft, Ellen</au><au>Brotman, Melissa A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional connectivity during masked and unmasked face emotion processing in bipolar disorder</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res Neuroimaging</addtitle><date>2016-12-30</date><risdate>2016</risdate><volume>258</volume><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0925-4927</issn><eissn>1872-7506</eissn><abstract>Abstract Little is known regarding the neural connectivity and correlates during automatic, unconscious face emotion processing in individuals with bipolar disorder (BD). In this study, 14 adults with BD and 14 healthy volunteers (HV) underwent fMRI scanning while completing an affective priming task with unconsciously perceived and consciously perceived faces (angry, happy, neutral, blank oval). We found that, regardless of awareness level and emotion types, BD patients exhibited diminished functional connectivity between amygdala and ventromedial prefrontal cortex (vmPFC) compared to HV. This connectivity finding is present in the absence of activation differences in amygdala. In addition, in medial frontal gyrus, BD patients displayed greater activation while HV displayed less activation to angry and neutral faces compared to no face. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Amygdala - diagnostic imaging Amygdala - physiopathology Backward masking Bipolar disorder Bipolar Disorder - diagnostic imaging Bipolar Disorder - physiopathology Bipolar Disorder - psychology Emotions - physiology Face emotion processing Facial Expression Female Frontal Lobe - diagnostic imaging Frontal Lobe - physiopathology Functional connectivity Functional Neuroimaging Humans Magnetic Resonance Imaging Male Middle Aged Psychiatry Radiology Young Adult |
| title | Functional connectivity during masked and unmasked face emotion processing in bipolar disorder |
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