Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study
The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing-remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method. ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain...
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| Veröffentlicht in: | Neuropsychiatric disease and treatment 2016-01, Vol.12, p.3031-3039 |
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| creator | Liu, Heng Chen, Hua Wu, Bo Zhang, Tijiang Wang, Jinhui Huang, Kexin Song, Ganjun Zhan, Jian |
| description | The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing-remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method.
ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain activities in patients with RRMS in comparison with healthy controls (HCs). The beta values of altered brain regions between patients with RRMS and HCs were extracted, and a receiver operating characteristic (ROC) curve was generated to calculate the sensitivities and specificities of these different brain areas for distinguishing patients with RRMS from HCs. Pearson correlation analyses were applied to assess the relationships between the beta values of altered brain regions and disease duration and Expanded Disability Status Scale (EDSS) score.
A total of 18 patients with RRMS (13 females; five males) and 18 sex-, age-, and education-matched HCs (14 females; four males) were recruited for this study.
Compared with HCs, patients with RRMS showed higher ALFF responses in the right fusiform gyrus (Brodmann area [BA] 37) and lower ALFF responses in the bilateral anterior cingulate cortices (BA 24 and 32), bilateral heads of the caudate nuclei, and bilateral brainstem. The ROC analysis revealed that the beta values of these abnormal brain areas showed high degrees of sensitivity and specificity for distinguishing patients with RRMS from HCs. The EDSS score showed a significant negative Pearson correlation with the beta value of the caudate head (
=-0.474,
=0.047).
RRMS is associated with disturbances in spontaneous regional brain activity in specific areas, and these specific abnormalities may provide important information about the neural mechanisms underlying behavioral impairment in RRMS. |
| doi_str_mv | 10.2147/NDT.S120909 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5135476</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A506651528</galeid><sourcerecordid>A506651528</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-76a3e5a8197bdc97a176ba95fe3fe3f3ca9f4d4617a275c6bbe79e87d7c1ed863</originalsourceid><addsrcrecordid>eNptkt9r1TAUx4sobk6ffJeCIIL0mqRNk-xBGNPpYCrofA6n6WlvRvrDJBUG_vGm7jp3RRLI4eRzviHnfLPsKSUbRivx-tPby81Xyogi6l52SKmQBSOM3v8d10VdMnmQPQrhipBSKCkfZgdMqJSV5WH282wZTbTTCC43k4_WrMEWxh5Dbsfco4M52LEvPA42xhTlw-KinR3mwTj0U7Ahh5jDMDsblxaTztjZfvGw6h7nkETCWliECBHz7uOX8zwk8vpx9qADF_DJ7jzKvp29uzz9UFx8fn9-enJRGE5ELEQNJXKQVImmNUpA-lYDindYrrs0oLqqrWoqgAlu6qZBoVCKVhiKrazLo-zNje68NAO2BsfowenZ2wH8tZ7A6v2b0W51P_3QnJa8EqvAy52An74v6Td6sMGgczDitARNZSWkYkqShD7_B72aFp_aGzRjFRFcVYr_pXpwqO3YTelds4rqE07qmlPOZKI2_6HSatMsUpexsym_V_DiTsEWwcVtmNyyDiLsg69uQJPmFzx2t82gRK-u0slVeueqRD-7279b9o-Nyl90Aclf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2240759495</pqid></control><display><type>article</type><title>Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study</title><source>Taylor & Francis Open Access</source><source>DOVE Medical Press Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Liu, Heng ; Chen, Hua ; Wu, Bo ; Zhang, Tijiang ; Wang, Jinhui ; Huang, Kexin ; Song, Ganjun ; Zhan, Jian</creator><creatorcontrib>Liu, Heng ; Chen, Hua ; Wu, Bo ; Zhang, Tijiang ; Wang, Jinhui ; Huang, Kexin ; Song, Ganjun ; Zhan, Jian</creatorcontrib><description>The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing-remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method.
ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain activities in patients with RRMS in comparison with healthy controls (HCs). The beta values of altered brain regions between patients with RRMS and HCs were extracted, and a receiver operating characteristic (ROC) curve was generated to calculate the sensitivities and specificities of these different brain areas for distinguishing patients with RRMS from HCs. Pearson correlation analyses were applied to assess the relationships between the beta values of altered brain regions and disease duration and Expanded Disability Status Scale (EDSS) score.
A total of 18 patients with RRMS (13 females; five males) and 18 sex-, age-, and education-matched HCs (14 females; four males) were recruited for this study.
Compared with HCs, patients with RRMS showed higher ALFF responses in the right fusiform gyrus (Brodmann area [BA] 37) and lower ALFF responses in the bilateral anterior cingulate cortices (BA 24 and 32), bilateral heads of the caudate nuclei, and bilateral brainstem. The ROC analysis revealed that the beta values of these abnormal brain areas showed high degrees of sensitivity and specificity for distinguishing patients with RRMS from HCs. The EDSS score showed a significant negative Pearson correlation with the beta value of the caudate head (
=-0.474,
=0.047).
RRMS is associated with disturbances in spontaneous regional brain activity in specific areas, and these specific abnormalities may provide important information about the neural mechanisms underlying behavioral impairment in RRMS.</description><identifier>ISSN: 1176-6328</identifier><identifier>ISSN: 1178-2021</identifier><identifier>EISSN: 1178-2021</identifier><identifier>DOI: 10.2147/NDT.S120909</identifier><identifier>PMID: 27932883</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Abnormalities ; Atrophy ; Brain ; Brain cancer ; Brain diseases ; Brain research ; Cognitive ability ; Disease ; Education ; Hospitals ; Magnetic resonance imaging ; Males ; Mental disorders ; Methods ; Multiple sclerosis ; Nervous system ; Neurodegeneration ; Neurology ; NMR ; Nuclear magnetic resonance ; Original Research ; Physiological aspects ; Sleep disorders ; Studies ; Traumatic brain injury</subject><ispartof>Neuropsychiatric disease and treatment, 2016-01, Vol.12, p.3031-3039</ispartof><rights>COPYRIGHT 2016 Dove Medical Press Limited</rights><rights>2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Liu et al. This work is published and licensed by Dove Medical Press Limited 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-76a3e5a8197bdc97a176ba95fe3fe3f3ca9f4d4617a275c6bbe79e87d7c1ed863</citedby><orcidid>0000-0002-6108-5154</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135476/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135476/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,3849,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27932883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Heng</creatorcontrib><creatorcontrib>Chen, Hua</creatorcontrib><creatorcontrib>Wu, Bo</creatorcontrib><creatorcontrib>Zhang, Tijiang</creatorcontrib><creatorcontrib>Wang, Jinhui</creatorcontrib><creatorcontrib>Huang, Kexin</creatorcontrib><creatorcontrib>Song, Ganjun</creatorcontrib><creatorcontrib>Zhan, Jian</creatorcontrib><title>Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study</title><title>Neuropsychiatric disease and treatment</title><addtitle>Neuropsychiatr Dis Treat</addtitle><description>The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing-remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method.
ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain activities in patients with RRMS in comparison with healthy controls (HCs). The beta values of altered brain regions between patients with RRMS and HCs were extracted, and a receiver operating characteristic (ROC) curve was generated to calculate the sensitivities and specificities of these different brain areas for distinguishing patients with RRMS from HCs. Pearson correlation analyses were applied to assess the relationships between the beta values of altered brain regions and disease duration and Expanded Disability Status Scale (EDSS) score.
A total of 18 patients with RRMS (13 females; five males) and 18 sex-, age-, and education-matched HCs (14 females; four males) were recruited for this study.
Compared with HCs, patients with RRMS showed higher ALFF responses in the right fusiform gyrus (Brodmann area [BA] 37) and lower ALFF responses in the bilateral anterior cingulate cortices (BA 24 and 32), bilateral heads of the caudate nuclei, and bilateral brainstem. The ROC analysis revealed that the beta values of these abnormal brain areas showed high degrees of sensitivity and specificity for distinguishing patients with RRMS from HCs. The EDSS score showed a significant negative Pearson correlation with the beta value of the caudate head (
=-0.474,
=0.047).
RRMS is associated with disturbances in spontaneous regional brain activity in specific areas, and these specific abnormalities may provide important information about the neural mechanisms underlying behavioral impairment in RRMS.</description><subject>Abnormalities</subject><subject>Atrophy</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain diseases</subject><subject>Brain research</subject><subject>Cognitive ability</subject><subject>Disease</subject><subject>Education</subject><subject>Hospitals</subject><subject>Magnetic resonance imaging</subject><subject>Males</subject><subject>Mental disorders</subject><subject>Methods</subject><subject>Multiple sclerosis</subject><subject>Nervous system</subject><subject>Neurodegeneration</subject><subject>Neurology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Original Research</subject><subject>Physiological aspects</subject><subject>Sleep 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cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study</title><author>Liu, Heng ; Chen, Hua ; Wu, Bo ; Zhang, Tijiang ; Wang, Jinhui ; Huang, Kexin ; Song, Ganjun ; Zhan, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-76a3e5a8197bdc97a176ba95fe3fe3f3ca9f4d4617a275c6bbe79e87d7c1ed863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abnormalities</topic><topic>Atrophy</topic><topic>Brain</topic><topic>Brain cancer</topic><topic>Brain diseases</topic><topic>Brain research</topic><topic>Cognitive ability</topic><topic>Disease</topic><topic>Education</topic><topic>Hospitals</topic><topic>Magnetic resonance imaging</topic><topic>Males</topic><topic>Mental disorders</topic><topic>Methods</topic><topic>Multiple sclerosis</topic><topic>Nervous 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China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychiatric disease and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Heng</au><au>Chen, Hua</au><au>Wu, Bo</au><au>Zhang, Tijiang</au><au>Wang, Jinhui</au><au>Huang, Kexin</au><au>Song, Ganjun</au><au>Zhan, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study</atitle><jtitle>Neuropsychiatric disease and treatment</jtitle><addtitle>Neuropsychiatr Dis Treat</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>12</volume><spage>3031</spage><epage>3039</epage><pages>3031-3039</pages><issn>1176-6328</issn><issn>1178-2021</issn><eissn>1178-2021</eissn><abstract>The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing-remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method.
ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain activities in patients with RRMS in comparison with healthy controls (HCs). The beta values of altered brain regions between patients with RRMS and HCs were extracted, and a receiver operating characteristic (ROC) curve was generated to calculate the sensitivities and specificities of these different brain areas for distinguishing patients with RRMS from HCs. Pearson correlation analyses were applied to assess the relationships between the beta values of altered brain regions and disease duration and Expanded Disability Status Scale (EDSS) score.
A total of 18 patients with RRMS (13 females; five males) and 18 sex-, age-, and education-matched HCs (14 females; four males) were recruited for this study.
Compared with HCs, patients with RRMS showed higher ALFF responses in the right fusiform gyrus (Brodmann area [BA] 37) and lower ALFF responses in the bilateral anterior cingulate cortices (BA 24 and 32), bilateral heads of the caudate nuclei, and bilateral brainstem. The ROC analysis revealed that the beta values of these abnormal brain areas showed high degrees of sensitivity and specificity for distinguishing patients with RRMS from HCs. The EDSS score showed a significant negative Pearson correlation with the beta value of the caudate head (
=-0.474,
=0.047).
RRMS is associated with disturbances in spontaneous regional brain activity in specific areas, and these specific abnormalities may provide important information about the neural mechanisms underlying behavioral impairment in RRMS.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>27932883</pmid><doi>10.2147/NDT.S120909</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6108-5154</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Abnormalities Atrophy Brain Brain cancer Brain diseases Brain research Cognitive ability Disease Education Hospitals Magnetic resonance imaging Males Mental disorders Methods Multiple sclerosis Nervous system Neurodegeneration Neurology NMR Nuclear magnetic resonance Original Research Physiological aspects Sleep disorders Studies Traumatic brain injury |
| title | Functional cortical changes in relapsing-remitting multiple sclerosis at amplitude configuration: a resting-state fMRI study |
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