CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis

Abnormal expression of cyclin-dependent kinase 5 (CDK5) has been found in several human cancers, whereas the role of CDK5 in the malignant development of colorectal cancer (CRC) has not been well characterized. Here we investigated the role of CDK5 in CRC and found that its expression was much highe...

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Veröffentlicht in:	Cell death & disease 2016-10, Vol.7 (10), p.e2415-e2415
Hauptverfasser:	Zhuang, Kangmin, Zhang, Juchang, Xiong, Man, Wang, Xianfei, Luo, Xiaobei, Han, Lu, Meng, Yan, Zhang, Yali, Liao, Wenting, Liu, Side
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 38/39 631/45/275 631/67/1504/1885 631/80/86 64/60 692/420/755 Adaptor Proteins, Signal Transducing Antibodies Biochemistry Biomedical and Life Sciences Carcinogenesis - genetics Carcinogenesis - pathology Cell Biology Cell Culture Cell Cycle Proteins Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cyclin-Dependent Kinase 5 - metabolism Disease Progression Down-Regulation - genetics Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Immunology Life Sciences Male Middle Aged Mitogen-Activated Protein Kinase 7 - metabolism Neoplasm Invasiveness Neoplasm Metastasis Original original-article Phosphorylation Phosphothreonine - metabolism Protein expression Signal Transduction Survival Analysis Transcription Factor AP-1 - metabolism Tumorigenesis Up-Regulation - genetics
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