Gastrocnemius medialis muscle architecture and physiological cross sectional area in adult males with Duchenne muscular dystrophy
To describe muscle size and architecture of the gastrocnemius medialis (GM) muscle in eleven adult males with Duchenne Muscular Dystrophy (DMD, age 24.5±5.4 years), and a control group of eleven males without DMD (CTRL, age 22.1±0.9 years). GM anatomical cross sectional area (ACSA), volume (VOL), ph...
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| Veröffentlicht in: | Journal of musculoskeletal & neuronal interactions 2015-06, Vol.15 (2), p.154-160 |
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| creator | Morse, C I Smith, J Denny, A Tweedale, J Searle, N D |
| description | To describe muscle size and architecture of the gastrocnemius medialis (GM) muscle in eleven adult males with Duchenne Muscular Dystrophy (DMD, age 24.5±5.4 years), and a control group of eleven males without DMD (CTRL, age 22.1±0.9 years).
GM anatomical cross sectional area (ACSA), volume (VOL), physiological cross sectional area (PCSA), fascicle length (Lf) and pennation angle (θ) were assessed using B-Mode Ultrasonography. GM ACSA was measured at 25, 50 and 75% of muscle length (Lm), from which VOL was calculated. At 50% of Lm, sagittal plane images were analysed to determine GM Lf and θ. GM PCSA was calculated as: VOL/Lf. The ratio of Lf and Lm was also calculated.
GM ACSA at 50% Lm, VOL and PCSA were smaller in DMD males compared to CTRL males by 36, 47 and 43%, respectively (P |
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GM anatomical cross sectional area (ACSA), volume (VOL), physiological cross sectional area (PCSA), fascicle length (Lf) and pennation angle (θ) were assessed using B-Mode Ultrasonography. GM ACSA was measured at 25, 50 and 75% of muscle length (Lm), from which VOL was calculated. At 50% of Lm, sagittal plane images were analysed to determine GM Lf and θ. GM PCSA was calculated as: VOL/Lf. The ratio of Lf and Lm was also calculated.
GM ACSA at 50% Lm, VOL and PCSA were smaller in DMD males compared to CTRL males by 36, 47 and 43%, respectively (P<0.01). There were no differences in Lf and θ. GM Lm was 29% shorter in DMD compared to CTRL. Lf/Lm was 29% longer in DMD (P<0.01).
Unlike previous data in children with DMD, our results show significant atrophy in adult males with DMD, and no change in Lf or θ. The shorter Lm may have implications for joint flexibility.</description><identifier>ISSN: 1108-7161</identifier><identifier>PMID: 26032207</identifier><language>eng</language><publisher>Greece: International Society of Musculoskeletal and Neuronal Interactions</publisher><subject>Adult ; Aging ; Anatomy, Cross-Sectional ; Body Height ; Body Weight ; Humans ; Male ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - pathology ; Muscular Dystrophy, Duchenne - diagnostic imaging ; Muscular Dystrophy, Duchenne - pathology ; Original ; Ultrasonography ; Young Adult</subject><ispartof>Journal of musculoskeletal & neuronal interactions, 2015-06, Vol.15 (2), p.154-160</ispartof><rights>Copyright: © Journal of Musculoskeletal and Neuronal Interactions 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133718/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133718/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26032207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morse, C I</creatorcontrib><creatorcontrib>Smith, J</creatorcontrib><creatorcontrib>Denny, A</creatorcontrib><creatorcontrib>Tweedale, J</creatorcontrib><creatorcontrib>Searle, N D</creatorcontrib><title>Gastrocnemius medialis muscle architecture and physiological cross sectional area in adult males with Duchenne muscular dystrophy</title><title>Journal of musculoskeletal & neuronal interactions</title><addtitle>J Musculoskelet Neuronal Interact</addtitle><description>To describe muscle size and architecture of the gastrocnemius medialis (GM) muscle in eleven adult males with Duchenne Muscular Dystrophy (DMD, age 24.5±5.4 years), and a control group of eleven males without DMD (CTRL, age 22.1±0.9 years).
GM anatomical cross sectional area (ACSA), volume (VOL), physiological cross sectional area (PCSA), fascicle length (Lf) and pennation angle (θ) were assessed using B-Mode Ultrasonography. GM ACSA was measured at 25, 50 and 75% of muscle length (Lm), from which VOL was calculated. At 50% of Lm, sagittal plane images were analysed to determine GM Lf and θ. GM PCSA was calculated as: VOL/Lf. The ratio of Lf and Lm was also calculated.
GM ACSA at 50% Lm, VOL and PCSA were smaller in DMD males compared to CTRL males by 36, 47 and 43%, respectively (P<0.01). There were no differences in Lf and θ. GM Lm was 29% shorter in DMD compared to CTRL. Lf/Lm was 29% longer in DMD (P<0.01).
Unlike previous data in children with DMD, our results show significant atrophy in adult males with DMD, and no change in Lf or θ. The shorter Lm may have implications for joint flexibility.</description><subject>Adult</subject><subject>Aging</subject><subject>Anatomy, Cross-Sectional</subject><subject>Body Height</subject><subject>Body Weight</subject><subject>Humans</subject><subject>Male</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular Dystrophy, Duchenne - diagnostic imaging</subject><subject>Muscular Dystrophy, Duchenne - pathology</subject><subject>Original</subject><subject>Ultrasonography</subject><subject>Young Adult</subject><issn>1108-7161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhnNQbK3-Bdmjl8B-JJv0IkjVKhS89B4mm2mzstmt-6H06D831Sp6mnl54XmYOcmmjNE6r5hkk-w8hBdKOSs4PcsmXFLBOa2m2ccSQvROWRx0CmTAToPR45KCMkjAq15HVDH5MdiO7Pp90M64rVZgiPIuBBLGXjs7ZvAIRFsCXTKRDGAwkHcde3KXVI_W4hc3GfCk2x-8I-4iO92ACXh5nLNs_XC_Xjzmq-fl0-J2le-4lDFX7VwWYoNAhdwUtGZFgVWNXHZtW4FQnAMKLrisETrkFOqSVbxVCGVZdVTMsptv7C6145UKbfRgmp3XA_h940A3_xur-2br3pqSCVGxegRcHwHevSYMsRl0UGgMWHQpNEzWZVUyNj-4rv66fiU_bxefcyuCyA</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Morse, C I</creator><creator>Smith, J</creator><creator>Denny, A</creator><creator>Tweedale, J</creator><creator>Searle, N D</creator><general>International Society of Musculoskeletal and Neuronal Interactions</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201506</creationdate><title>Gastrocnemius medialis muscle architecture and physiological cross sectional area in adult males with Duchenne muscular dystrophy</title><author>Morse, C I ; Smith, J ; Denny, A ; Tweedale, J ; Searle, N D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-cb9643fea036f408144e78e26dbb7a3c22ae323268eade20a85172bcea557d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aging</topic><topic>Anatomy, Cross-Sectional</topic><topic>Body Height</topic><topic>Body Weight</topic><topic>Humans</topic><topic>Male</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular Dystrophy, Duchenne - diagnostic imaging</topic><topic>Muscular Dystrophy, Duchenne - pathology</topic><topic>Original</topic><topic>Ultrasonography</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Morse, C I</creatorcontrib><creatorcontrib>Smith, J</creatorcontrib><creatorcontrib>Denny, A</creatorcontrib><creatorcontrib>Tweedale, J</creatorcontrib><creatorcontrib>Searle, N D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of musculoskeletal & neuronal interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morse, C I</au><au>Smith, J</au><au>Denny, A</au><au>Tweedale, J</au><au>Searle, N D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrocnemius medialis muscle architecture and physiological cross sectional area in adult males with Duchenne muscular dystrophy</atitle><jtitle>Journal of musculoskeletal & neuronal interactions</jtitle><addtitle>J Musculoskelet Neuronal Interact</addtitle><date>2015-06</date><risdate>2015</risdate><volume>15</volume><issue>2</issue><spage>154</spage><epage>160</epage><pages>154-160</pages><issn>1108-7161</issn><abstract>To describe muscle size and architecture of the gastrocnemius medialis (GM) muscle in eleven adult males with Duchenne Muscular Dystrophy (DMD, age 24.5±5.4 years), and a control group of eleven males without DMD (CTRL, age 22.1±0.9 years).
GM anatomical cross sectional area (ACSA), volume (VOL), physiological cross sectional area (PCSA), fascicle length (Lf) and pennation angle (θ) were assessed using B-Mode Ultrasonography. GM ACSA was measured at 25, 50 and 75% of muscle length (Lm), from which VOL was calculated. At 50% of Lm, sagittal plane images were analysed to determine GM Lf and θ. GM PCSA was calculated as: VOL/Lf. The ratio of Lf and Lm was also calculated.
GM ACSA at 50% Lm, VOL and PCSA were smaller in DMD males compared to CTRL males by 36, 47 and 43%, respectively (P<0.01). There were no differences in Lf and θ. GM Lm was 29% shorter in DMD compared to CTRL. Lf/Lm was 29% longer in DMD (P<0.01).
Unlike previous data in children with DMD, our results show significant atrophy in adult males with DMD, and no change in Lf or θ. The shorter Lm may have implications for joint flexibility.</abstract><cop>Greece</cop><pub>International Society of Musculoskeletal and Neuronal Interactions</pub><pmid>26032207</pmid><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Aging Anatomy, Cross-Sectional Body Height Body Weight Humans Male Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - pathology Muscular Dystrophy, Duchenne - diagnostic imaging Muscular Dystrophy, Duchenne - pathology Original Ultrasonography Young Adult |
| title | Gastrocnemius medialis muscle architecture and physiological cross sectional area in adult males with Duchenne muscular dystrophy |
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