Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

The plasma membrane provides an essential barrier, shielding a cell from the pressures of its external environment. Pore-forming proteins, deployed by both hosts and pathogens alike, breach this barrier to lyse target cells. Intermedilysin is a cholesterol-dependent cytolysin that requires the human...

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Veröffentlicht in:	Scientific reports 2016-12, Vol.6 (1), p.38446-38446, Article 38446
Hauptverfasser:	Boyd, Courtney M., Parsons, Edward S., Smith, Richard A. G., Seddon, John M., Ces, Oscar, Bubeck, Doryen
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/1647/2204 631/326/421 631/57/2271 82/83 Atomic force microscopy Bacteriocins - chemistry Bacteriocins - genetics Bacteriocins - metabolism Binding Sites CD59 antigen CD59 Antigens - chemistry CD59 Antigens - genetics CD59 Antigens - metabolism Cell Membrane - chemistry Cell Membrane - metabolism Cell Membrane - ultrastructure Cholesterol Cholesterol - chemistry Cholesterol - metabolism Electron microscopy Host-Pathogen Interactions Humanities and Social Sciences Humans Microscopy, Atomic Force Monomers multidisciplinary Pore-forming proteins Porins - chemistry Porins - genetics Porins - metabolism Protein Domains - genetics Science Toxins
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