Multiple facets of p53 in senescence induction and maintenance
Cellular senescence is a state of durable cell cycle arrest with metabolic activities distinct from those of the proliferative state. Since senescence was originally reported to be induced by various genotoxic stressors, such as telomere erosion and oncogenic signaling, it has been proposed to play...
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| Veröffentlicht in: | Cancer science 2016-11, Vol.107 (11), p.1550-1555 |
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| creator | Johmura, Yoshikazu Nakanishi, Makoto |
| description | Cellular senescence is a state of durable cell cycle arrest with metabolic activities distinct from those of the proliferative state. Since senescence was originally reported to be induced by various genotoxic stressors, such as telomere erosion and oncogenic signaling, it has been proposed to play a pivotal role in aging‐related changes and as an antitumorigenic barrier in vivo. However, the mechanisms underlying its induction and maintenance remain entirely elusive. We have recently found that abrupt activation of p53 at G2 results in a cell skipping mitosis and subsequently undergoing senescence. Surprisingly, we have also found that downregulation of p53 by SCFFbxo22 is crucial for the induction of a senescence‐associated phenotype. In this review, we provide an overview of recent advances in understanding the mechanisms underlying the timing and magnitude of activation of p53 during senescence.
We provide an overview of recent advances in understanding the mechanisms underlying the timing and magnitude of activation of p53 during senescence. |
| doi_str_mv | 10.1111/cas.13060 |
| format | Article |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Wiley-Blackwell Open Access Titles; PubMed Central |
| subjects | Aging Animals Cancer Cell cycle Cellular Senescence - genetics Cellular Senescence - physiology Cytokines Deoxyribonucleic acid DNA DNA Damage DNA repair Fibroblasts Genotoxicity Genotype & phenotype Growth factors Humans Kinases Mitosis oncoprotein p53 p53 Protein Phenotypes Retina Retinoblastoma retinoblastoma protein Retinoblastoma Protein - metabolism Review Senescence Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumorigenesis |
| title | Multiple facets of p53 in senescence induction and maintenance |
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