Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster

Comparative transcriptional profiling of a ΔbldM mutant of Streptomyces venezuelae with its unmodified progenitor revealed that the expression of a cryptic biosynthetic gene cluster containing both type I and type III polyketide synthase genes is activated in the mutant. The 29.5 kb gene cluster, wh...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2016-11, Vol.17 (22), p.2189-2198
Hauptverfasser:	Thanapipatsiri, Anyarat, Gomez-Escribano, Juan Pablo, Song, Lijiang, Bibb, Maureen J., Al-Bassam, Mahmoud, Chandra, Govind, Thamchaipenet, Arinthip, Challis, Gregory L., Bibb, Mervyn J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism bldM FMN Reductase - genetics FMN Reductase - metabolism Genes halogenases Halogenation large ATP-binding LuxR-like regulator Multigene Family oxygen heterocycles Polyketide Synthases - genetics Polyketide Synthases - metabolism polyketides Polyketides - chemistry Polyketides - metabolism Streptomyces - enzymology Streptomyces - genetics Streptomyces coelicolor Streptomyces venezuelae
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