Coupled enhancer and coding sequence evolution of a homeobox gene shaped leaf diversity
Here we investigate mechanisms underlying the diversification of biological forms using crucifer leaf shape as an example. We show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY (RCO) altered leaf shape by changing gene expression from the distal leaf blade to its base...
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| Veröffentlicht in: | Genes & development 2016-11, Vol.30 (21), p.2370-2375 |
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| creator | Vuolo, Francesco Mentink, Remco A Hajheidari, Mohsen Bailey, C Donovan Filatov, Dmitry A Tsiantis, Miltos |
| description | Here we investigate mechanisms underlying the diversification of biological forms using crucifer leaf shape as an example. We show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY (RCO) altered leaf shape by changing gene expression from the distal leaf blade to its base. A single amino acid substitution evolved together with this regulatory change, which reduced RCO protein stability, preventing pleiotropic effects caused by its altered gene expression. We detected hallmarks of positive selection in these evolved regulatory and coding sequence variants and showed that modulating RCO activity can improve plant physiological performance. Therefore, interplay between enhancer and coding sequence evolution created a potentially adaptive path for morphological evolution. |
| doi_str_mv | 10.1101/gad.290684.116 |
| format | Article |
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We show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY (RCO) altered leaf shape by changing gene expression from the distal leaf blade to its base. A single amino acid substitution evolved together with this regulatory change, which reduced RCO protein stability, preventing pleiotropic effects caused by its altered gene expression. We detected hallmarks of positive selection in these evolved regulatory and coding sequence variants and showed that modulating RCO activity can improve plant physiological performance. 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Therefore, interplay between enhancer and coding sequence evolution created a potentially adaptive path for morphological evolution.</description><subject>Arabidopsis - anatomy & histology</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - physiology</subject><subject>Cardamine - anatomy & histology</subject><subject>Cardamine - classification</subject><subject>Cardamine - genetics</subject><subject>Enhancer Elements, Genetic - genetics</subject><subject>Evolution, Molecular</subject><subject>Gene Expression Profiling</subject><subject>Genes, Plant - genetics</subject><subject>Plant Leaves - anatomy & histology</subject><subject>Plant Leaves - genetics</subject><subject>Research Communication</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1vEzEQxS0EoqFw5Yh85LLBY3v9calURS0gVeIC4mh57dlk0cYO692I_Pc1SqnaG6fRm3nzNKMfIe-BrQEYfNr6uOaWKSOrVi_IClppm1Zq_ZKsmLGssULZC_KmlF-MMcWUek0uuDYtV9yuyM9NXg4jRopp51PAifoUachxSFta8PeCtUnxmMdlHnKiuaee7vIec5f_0C0mpGXnDzVgRN_TOBxxKsN8ekte9X4s-O6hXpIftzffN1-au2-fv26u75ogjZ0bz0AFtDJa1MBDKyF0HITXRkNnvOJR867nRqjQeSnQCGTCt8JEK4LqUFySq3PuYen2GAOmefKjO0zD3k8nl_3gnk_SsHPbfHQtCNBa14CPDwFTrt-W2e2HEnAcfcK8FAemtVKD0uY_rBJASGZ4ta7P1jDlUibsHy8C5v6CcxWcO4OrWtWFD0__eLT_IyXuAa_OlVY</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Vuolo, Francesco</creator><creator>Mentink, Remco A</creator><creator>Hajheidari, Mohsen</creator><creator>Bailey, C Donovan</creator><creator>Filatov, Dmitry A</creator><creator>Tsiantis, Miltos</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20161101</creationdate><title>Coupled enhancer and coding sequence evolution of a homeobox gene shaped leaf diversity</title><author>Vuolo, Francesco ; Mentink, Remco A ; Hajheidari, Mohsen ; Bailey, C Donovan ; Filatov, Dmitry A ; Tsiantis, Miltos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-a016ce94d9e712c541cb213a7871b8a62d72bf2836cba43e83e03a538d93c6be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Arabidopsis - anatomy & histology</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - physiology</topic><topic>Cardamine - anatomy & histology</topic><topic>Cardamine - classification</topic><topic>Cardamine - genetics</topic><topic>Enhancer Elements, Genetic - genetics</topic><topic>Evolution, Molecular</topic><topic>Gene Expression Profiling</topic><topic>Genes, Plant - genetics</topic><topic>Plant Leaves - anatomy & histology</topic><topic>Plant Leaves - genetics</topic><topic>Research Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vuolo, Francesco</creatorcontrib><creatorcontrib>Mentink, Remco A</creatorcontrib><creatorcontrib>Hajheidari, Mohsen</creatorcontrib><creatorcontrib>Bailey, C Donovan</creatorcontrib><creatorcontrib>Filatov, Dmitry A</creatorcontrib><creatorcontrib>Tsiantis, Miltos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vuolo, Francesco</au><au>Mentink, Remco A</au><au>Hajheidari, Mohsen</au><au>Bailey, C Donovan</au><au>Filatov, Dmitry A</au><au>Tsiantis, Miltos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coupled enhancer and coding sequence evolution of a homeobox gene shaped leaf diversity</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>30</volume><issue>21</issue><spage>2370</spage><epage>2375</epage><pages>2370-2375</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>Here we investigate mechanisms underlying the diversification of biological forms using crucifer leaf shape as an example. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Arabidopsis - anatomy & histology Arabidopsis - genetics Arabidopsis - physiology Cardamine - anatomy & histology Cardamine - classification Cardamine - genetics Enhancer Elements, Genetic - genetics Evolution, Molecular Gene Expression Profiling Genes, Plant - genetics Plant Leaves - anatomy & histology Plant Leaves - genetics Research Communication |
| title | Coupled enhancer and coding sequence evolution of a homeobox gene shaped leaf diversity |
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