Changes in urinary metabolomic profile during relapsing renal vasculitis

Current biomarkers of renal disease in systemic vasculitis lack predictive value and are insensitive to early damage. To identify novel biomarkers of renal vasculitis flare, we analysed the longitudinal urinary metabolomic profile of a rat model of anti-neutrophil cytoplasmic antibody (ANCA) vasculi...

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Veröffentlicht in:	Scientific reports 2016-12, Vol.6 (1), p.38074, Article 38074
Hauptverfasser:	Al-Ani, Bahjat, Fitzpatrick, Martin, Al-Nuaimi, Hamad, Coughlan, Alice M., Hickey, Fionnuala B., Pusey, Charles D., Savage, Caroline, Benton, Christopher M., O’Brien, Eóin C., O’Toole, Declan, Mok, Ken H., Young, Stephen P., Little, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/63 631/1647/320 631/250/38 Animals Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - urine Antineutrophil cytoplasmic antibodies Biomarkers Citric acid Citric Acid - urine Disease Models, Animal Female Humanities and Social Sciences Humans Immunization Inositol Ketoglutaric acid Ketoglutaric Acids - urine Kidney Diseases - urine Kidney transplantation Least-Squares Analysis Liquid chromatography Male Mass spectrometry Mass spectroscopy Metabolites Metabolomics Metabolomics - methods Methylamines - urine multidisciplinary NMR Nuclear magnetic resonance Peroxidase Peroxidase - administration & dosage Peroxidase - immunology Rats Rats, Inbred WKY Recurrence Rodents Science Spectroscopy Systemic vasculitis Trimethylamine Urine
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