High content imaging quantification of multiple in vitro human neurogenesis events after neurotoxin exposure

Our objective was to test neural active compounds in a human developmental neurotoxicity (DNT) model that represents neural tube stages of vulnerability. Previously we showed that 14 days in vitro (DIV 14) was sufficient to generate cryopreserved neuronal cells for post thaw neurite recovery assays....

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Veröffentlicht in:	BMC pharmacology & toxicology 2016-12, Vol.17 (1), p.62-62, Article 62
Hauptverfasser:	Wu, Xian, Majumder, Anirban, Webb, Robin, Stice, Steven L
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Acetaminophen Acids Axonogenesis Bisphenol A Cell culture Cell differentiation Cell growth Cell Proliferation - drug effects Cell Proliferation - physiology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Chemicals Contaminants Cryopreservation Cytotoxicity Defects Dose-Response Relationship, Drug Endocrine active compounds Estradiol Estrogen receptors Estrogens Exposure Humans Immunocytochemistry Indoles - toxicity Leukemia Maleimides - toxicity Maturation Model testing Molecular Imaging - methods Molecular Imaging - standards Nervous system Neural Stem Cells - drug effects Neural Stem Cells - physiology Neural tube Neurites - drug effects Neurites - physiology Neurogenesis Neurogenesis - drug effects Neurogenesis - physiology Neurons Neurotoxicity Neurotoxins Recovery Sex hormones Testosterone Toxicants Toxicity Toxins Tubulin Tubulins Variance analysis
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