Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency

Pain perception can become altered in individuals with eating disorders and obesity for reasons that have not been fully elucidated. We show that leptin deficiency in ob/ob mice, or leptin insensitivity in the arcuate nucleus of the hypothalamus in mice with high-fat diet (HFD)-induced obesity, are...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2016-01, Vol.41 (2), p.508-520
Hauptverfasser:	Cristino, Luigia, Luongo, Livio, Imperatore, Roberta, Boccella, Serena, Becker, Thorsten, Morello, Giovanna, Piscitelli, Fabiana, Busetto, Giuseppe, Maione, Sabatino, Di Marzo, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - metabolism Disease Models, Animal Eating disorders Endocannabinoids - metabolism Glycerides - metabolism Hypothalamus Leptin - metabolism Male Membrane Potentials - physiology Mice, Obese Neural Pathways - pathology Neural Pathways - physiopathology Neurons - pathology Neurons - physiology Nociceptive Pain - pathology Nociceptive Pain - physiopathology Obesity Orexin Receptors - metabolism Orexins - metabolism Original Pain Pain Perception - physiology Periaqueductal Gray - pathology Periaqueductal Gray - physiopathology Tissue Culture Techniques
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