Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230

Fibroblast growth factor (FGF) ligand-dependent signaling has a fundamental role in cancer development and tumor maintenance. GSK3052230 (also known as FP-1039) is a soluble decoy receptor that sequesters FGFs and inhibits FGFR signaling. Herein, the efficacy of this molecule was tested in models of...

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Veröffentlicht in:	Oncotarget 2016-06, Vol.7 (26), p.39861-39871
Hauptverfasser:	Blackwell, Christina, Sherk, Christian, Fricko, Maggie, Ganji, Gopinath, Barnette, Mary, Hoang, Bao, Tunstead, James, Skedzielewski, Tina, Alsaid, Hasan, Jucker, Beat M, Minthorn, Elisabeth, Kumar, Rakesh, DeYoung, M Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autocrine Communication Cell Line Cell Proliferation Female Fibroblast Growth Factors - metabolism Gene Expression Regulation, Neoplastic Humans Immunoglobulin G - chemistry Ligands Magnetic Resonance Imaging Mesothelioma - metabolism Mice Mice, SCID Neoplasm Transplantation Neovascularization, Pathologic Oncogene Proteins, Fusion - chemistry Receptor, Fibroblast Growth Factor, Type 1 - chemistry Receptor, Fibroblast Growth Factor, Type 1 - metabolism Research Paper Signal Transduction
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