Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1

Insulin-like growth factor-1 (IGF-1) is an important regulator of cardiomyocyte homeostasis and cardiac structure, and the prosurvival and antiapoptotic effects of IGF-1 have been investigated. However, the effect of microRNA-320 (miR-320) in ischemia and reperfusion (I/R) by targeting IGF-1 is rare...

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Veröffentlicht in:	Oncotarget 2016-06, Vol.7 (26), p.39740-39757
Hauptverfasser:	Song, Chun-Li, Liu, Bin, Diao, Hong-Ying, Shi, Yong-Feng, Zhang, Ji-Chang, Li, Yang-Xue, Liu, Ning, Yu, Yun-Peng, Wang, Guan, Wang, Jin-Peng, Li, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Binding Sites Caspase 3 - metabolism Down-Regulation Female Hemodynamics Insulin-Like Growth Factor I - metabolism MicroRNAs - genetics MicroRNAs - metabolism Myocardial Infarction - pathology Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Wistar Reperfusion Injury - metabolism Research Paper
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