Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish

Mutations affecting Gαq proteins are pervasive in uveal melanoma (UM), suggesting they 'drive' UM pathogenesis. The ERK1/2-MAPK pathway is critical for cutaneous melanoma development and consequently an important therapeutic target. Defining the contribution of ERK1/2-MAPK signalling to UM...

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Veröffentlicht in:	Oncotarget 2016-06, Vol.7 (26), p.39654-39670
Hauptverfasser:	Mouti, Mai Abdel, Dee, Christopher, Coupland, Sarah E, Hurlstone, Adam F L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Carcinogens Cell Line Cell Lineage DNA Transposable Elements Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Profiling Gene Expression Regulation Genes, p53 Humans Immunohistochemistry MAP Kinase Signaling System Melanocytes - metabolism Mutation Research Paper Signal Transduction Uveal Neoplasms - enzymology Uveal Neoplasms - genetics Zebrafish
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