Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency

The two evolutionarily conserved mammalian lipid kinases Vps34 and PIKfyve are involved in an important physiological relationship, whereby the former produces phosphatidylinositol (PtdIns) 3P that is used as a substrate for PtdIns(3,5)P2 synthesis by the latter. Reduced production of PtdIns(3,5)P2...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2016-09, Vol.311 (3), p.C366-C377
Hauptverfasser:	Compton, Lauren M, Ikonomov, Ognian C, Sbrissa, Diego, Garg, Puneet, Shisheva, Assia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Animals Call for Papers Cell Line Cell Membrane - drug effects Cell Membrane - metabolism Cercopithecus aethiops Class III Phosphatidylinositol 3-Kinases - metabolism COS Cells Endocytosis - drug effects Endosomes - drug effects Endosomes - metabolism Heterocyclic Compounds, 3-Ring - pharmacology Macrolides - pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Phosphates - metabolism Phosphatidylinositols - metabolism rab5 GTP-Binding Proteins - metabolism Vacuolar Proton-Translocating ATPases - metabolism Vacuoles - drug effects Vacuoles - metabolism
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