Rate and Predisposing Factors for Sacroiliac Joint Radiographic Progression After a Two‐Year Follow‐up Period in Recent‐Onset Spondyloarthritis
Objective To evaluate the rate of radiographic structural progression in the sacroiliac (SI) joints in patients with radiographic or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing to such progression, over 2 years. Methods Patients with recent‐onset axial SpA (f...
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2016-08, Vol.68 (8), p.1904-1913 |
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| creator | Dougados, Maxime Demattei, Christophe van den Berg, Rosaline Vo Hoang, Viet Thevenin, Fabrice Reijnierse, Monique Loeuille, Damien Feydy, Antoine Claudepierre, Pascal van der Heijde, Désirée |
| description | Objective
To evaluate the rate of radiographic structural progression in the sacroiliac (SI) joints in patients with radiographic or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing to such progression, over 2 years.
Methods
Patients with recent‐onset axial SpA (from the Devenir des Spondyloarthropathies Indifferérenciées Récentes cohort) were assigned a radiographic SI joint score according to the modified New York criteria. Demographic characteristics, smoking status, HLA–B27 positivity, inflammation on magnetic resonance imaging (MRI) of the SI joints, disease activity, and treatment were investigated as potential predisposing factors. The main analysis consisted of the evaluation of the switch from nonradiographic to radiographic axial SpA, but other definitions of radiographic progression were also evaluated.
Results
Of the 708 patients enrolled, 449 had baseline and 2‐year pelvic radiographs. Of these patients, 47% were men. Their mean ± SD age was 34 ± 9 years, 61% were B27 positive, and 37% had inflammation of the SI joints on MRI. The percentages of patients who switched from nonradiographic to radiographic axial SpA (4.9% [16 of 326]) and from radiographic to nonradiographic axial SpA (5.7% [7 of 123]) were low. The mean ± SD change in the total SI joint score (range 0–8) was small (0.1 ± 0.8) but highly significant (P |
| doi_str_mv | 10.1002/art.39666 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5129505</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1811877626</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5106-e1347b1aba19ecac7b3b5413943050cfc16689548a72ae5926852402d94cab563</originalsourceid><addsrcrecordid>eNqNksFuEzEQhleIilZtD30BZIkLHNLaXtu7viBFFaGgSK3ScOjJmvV6E1cbe7F3G-XGI3DhBXkSnKYtUAkJXzwz_ub3eDxZdkLwKcGYnkHoT3MphHiRHdCcihGnmL98tIkk-9lxjLc4LVlggfmrbJ8KKTEn5UH2Ywa9QeBqdBVMbWPno3ULNAHd-xBR4wO6Bh28bS1o9Nlb16MZ1NYvAnRLq1NaMk2M1js0bnoTEKD52v_89v3GQEAT37Z-nbyhQ1cmWF8j69DMaOP6FL100fTouvOu3rQ-PWUZbG_jUbbXQBvN8cN-mH2ZfJifX4ymlx8_nY-nI80JFiNDclZUBCog0mjQRZVXnJFcshxzrBtNhCglZyUUFAyXVJScMkxryTRUXOSH2fudbjdUK1NviwrQqi7YFYSN8mDV3yfOLtXC3ylOqOSYJ4F3O4Hls7SL8VRtY5gwTnMs70hi3z5cFvzXwcRerWzUpm3BGT9ERUpCyqIQVPwHiguec16yhL55ht76IbjUtXsKM84k_l1n-soYg2meiiVYbcdIpd6r-zFK7Os_m_JEPg5NAs52wNq2ZvNvJTWezXeSvwDsNNUZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1807045490</pqid></control><display><type>article</type><title>Rate and Predisposing Factors for Sacroiliac Joint Radiographic Progression After a Two‐Year Follow‐up Period in Recent‐Onset Spondyloarthritis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Dougados, Maxime ; Demattei, Christophe ; van den Berg, Rosaline ; Vo Hoang, Viet ; Thevenin, Fabrice ; Reijnierse, Monique ; Loeuille, Damien ; Feydy, Antoine ; Claudepierre, Pascal ; van der Heijde, Désirée</creator><creatorcontrib>Dougados, Maxime ; Demattei, Christophe ; van den Berg, Rosaline ; Vo Hoang, Viet ; Thevenin, Fabrice ; Reijnierse, Monique ; Loeuille, Damien ; Feydy, Antoine ; Claudepierre, Pascal ; van der Heijde, Désirée</creatorcontrib><description>Objective
To evaluate the rate of radiographic structural progression in the sacroiliac (SI) joints in patients with radiographic or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing to such progression, over 2 years.
Methods
Patients with recent‐onset axial SpA (from the Devenir des Spondyloarthropathies Indifferérenciées Récentes cohort) were assigned a radiographic SI joint score according to the modified New York criteria. Demographic characteristics, smoking status, HLA–B27 positivity, inflammation on magnetic resonance imaging (MRI) of the SI joints, disease activity, and treatment were investigated as potential predisposing factors. The main analysis consisted of the evaluation of the switch from nonradiographic to radiographic axial SpA, but other definitions of radiographic progression were also evaluated.
Results
Of the 708 patients enrolled, 449 had baseline and 2‐year pelvic radiographs. Of these patients, 47% were men. Their mean ± SD age was 34 ± 9 years, 61% were B27 positive, and 37% had inflammation of the SI joints on MRI. The percentages of patients who switched from nonradiographic to radiographic axial SpA (4.9% [16 of 326]) and from radiographic to nonradiographic axial SpA (5.7% [7 of 123]) were low. The mean ± SD change in the total SI joint score (range 0–8) was small (0.1 ± 0.8) but highly significant (P < 0.001). The potential baseline predisposing factors for meeting the modified New York criteria in the multivariate analysis were current smoking, HLA–B27 positivity, and inflammation of the SI joints on MRI, with odds ratios of 3.3 (95% confidence interval [95% CI] 1.0–11.5], 12.6 (95% CI 2.3–274), and 48.8 (95% CI 9.3–904), respectively.
Conclusion
Our findings suggest that structural progression does exist in early SpA, but it is quite small and observed in a small number of patients, and that environmental (smoking status), genetic (HLA–B27 positivity), and inflammation (inflammation of the SI joints on MRI) markers might be independent predisposing factors for progression.</description><identifier>ISSN: 2326-5191</identifier><identifier>ISSN: 2326-5205</identifier><identifier>EISSN: 2326-5205</identifier><identifier>EISSN: 2326-5191</identifier><identifier>DOI: 10.1002/art.39666</identifier><identifier>PMID: 26990518</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Biochemistry ; Biochemistry, Molecular Biology ; Causality ; Disease Progression ; Female ; Follow-Up Studies ; Human health and pathology ; Humans ; Life Sciences ; Magnetic Resonance Imaging ; Male ; Sacroiliac Joint - diagnostic imaging ; Spondylarthritis - diagnostic imaging ; Spondylarthritis - epidemiology ; Spondyloarthritis ; Time Factors</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2016-08, Vol.68 (8), p.1904-1913</ispartof><rights>2016 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.</rights><rights>2016, American College of Rheumatology</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5106-e1347b1aba19ecac7b3b5413943050cfc16689548a72ae5926852402d94cab563</citedby><cites>FETCH-LOGICAL-c5106-e1347b1aba19ecac7b3b5413943050cfc16689548a72ae5926852402d94cab563</cites><orcidid>0000-0003-3009-6229 ; 0000-0001-8204-5701 ; 0000-0001-6955-9281</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.39666$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.39666$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26990518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lorraine.fr/hal-01452309$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dougados, Maxime</creatorcontrib><creatorcontrib>Demattei, Christophe</creatorcontrib><creatorcontrib>van den Berg, Rosaline</creatorcontrib><creatorcontrib>Vo Hoang, Viet</creatorcontrib><creatorcontrib>Thevenin, Fabrice</creatorcontrib><creatorcontrib>Reijnierse, Monique</creatorcontrib><creatorcontrib>Loeuille, Damien</creatorcontrib><creatorcontrib>Feydy, Antoine</creatorcontrib><creatorcontrib>Claudepierre, Pascal</creatorcontrib><creatorcontrib>van der Heijde, Désirée</creatorcontrib><title>Rate and Predisposing Factors for Sacroiliac Joint Radiographic Progression After a Two‐Year Follow‐up Period in Recent‐Onset Spondyloarthritis</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis Rheumatol</addtitle><description>Objective
To evaluate the rate of radiographic structural progression in the sacroiliac (SI) joints in patients with radiographic or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing to such progression, over 2 years.
Methods
Patients with recent‐onset axial SpA (from the Devenir des Spondyloarthropathies Indifferérenciées Récentes cohort) were assigned a radiographic SI joint score according to the modified New York criteria. Demographic characteristics, smoking status, HLA–B27 positivity, inflammation on magnetic resonance imaging (MRI) of the SI joints, disease activity, and treatment were investigated as potential predisposing factors. The main analysis consisted of the evaluation of the switch from nonradiographic to radiographic axial SpA, but other definitions of radiographic progression were also evaluated.
Results
Of the 708 patients enrolled, 449 had baseline and 2‐year pelvic radiographs. Of these patients, 47% were men. Their mean ± SD age was 34 ± 9 years, 61% were B27 positive, and 37% had inflammation of the SI joints on MRI. The percentages of patients who switched from nonradiographic to radiographic axial SpA (4.9% [16 of 326]) and from radiographic to nonradiographic axial SpA (5.7% [7 of 123]) were low. The mean ± SD change in the total SI joint score (range 0–8) was small (0.1 ± 0.8) but highly significant (P < 0.001). The potential baseline predisposing factors for meeting the modified New York criteria in the multivariate analysis were current smoking, HLA–B27 positivity, and inflammation of the SI joints on MRI, with odds ratios of 3.3 (95% confidence interval [95% CI] 1.0–11.5], 12.6 (95% CI 2.3–274), and 48.8 (95% CI 9.3–904), respectively.
Conclusion
Our findings suggest that structural progression does exist in early SpA, but it is quite small and observed in a small number of patients, and that environmental (smoking status), genetic (HLA–B27 positivity), and inflammation (inflammation of the SI joints on MRI) markers might be independent predisposing factors for progression.</description><subject>Adult</subject><subject>Biochemistry</subject><subject>Biochemistry, Molecular Biology</subject><subject>Causality</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Sacroiliac Joint - diagnostic imaging</subject><subject>Spondylarthritis - diagnostic imaging</subject><subject>Spondylarthritis - epidemiology</subject><subject>Spondyloarthritis</subject><subject>Time Factors</subject><issn>2326-5191</issn><issn>2326-5205</issn><issn>2326-5205</issn><issn>2326-5191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqNksFuEzEQhleIilZtD30BZIkLHNLaXtu7viBFFaGgSK3ScOjJmvV6E1cbe7F3G-XGI3DhBXkSnKYtUAkJXzwz_ub3eDxZdkLwKcGYnkHoT3MphHiRHdCcihGnmL98tIkk-9lxjLc4LVlggfmrbJ8KKTEn5UH2Ywa9QeBqdBVMbWPno3ULNAHd-xBR4wO6Bh28bS1o9Nlb16MZ1NYvAnRLq1NaMk2M1js0bnoTEKD52v_89v3GQEAT37Z-nbyhQ1cmWF8j69DMaOP6FL100fTouvOu3rQ-PWUZbG_jUbbXQBvN8cN-mH2ZfJifX4ymlx8_nY-nI80JFiNDclZUBCog0mjQRZVXnJFcshxzrBtNhCglZyUUFAyXVJScMkxryTRUXOSH2fudbjdUK1NviwrQqi7YFYSN8mDV3yfOLtXC3ylOqOSYJ4F3O4Hls7SL8VRtY5gwTnMs70hi3z5cFvzXwcRerWzUpm3BGT9ERUpCyqIQVPwHiguec16yhL55ht76IbjUtXsKM84k_l1n-soYg2meiiVYbcdIpd6r-zFK7Os_m_JEPg5NAs52wNq2ZvNvJTWezXeSvwDsNNUZ</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Dougados, Maxime</creator><creator>Demattei, Christophe</creator><creator>van den Berg, Rosaline</creator><creator>Vo Hoang, Viet</creator><creator>Thevenin, Fabrice</creator><creator>Reijnierse, Monique</creator><creator>Loeuille, Damien</creator><creator>Feydy, Antoine</creator><creator>Claudepierre, Pascal</creator><creator>van der Heijde, Désirée</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3009-6229</orcidid><orcidid>https://orcid.org/0000-0001-8204-5701</orcidid><orcidid>https://orcid.org/0000-0001-6955-9281</orcidid></search><sort><creationdate>201608</creationdate><title>Rate and Predisposing Factors for Sacroiliac Joint Radiographic Progression After a Two‐Year Follow‐up Period in Recent‐Onset Spondyloarthritis</title><author>Dougados, Maxime ; Demattei, Christophe ; van den Berg, Rosaline ; Vo Hoang, Viet ; Thevenin, Fabrice ; Reijnierse, Monique ; Loeuille, Damien ; Feydy, Antoine ; Claudepierre, Pascal ; van der Heijde, Désirée</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5106-e1347b1aba19ecac7b3b5413943050cfc16689548a72ae5926852402d94cab563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Biochemistry</topic><topic>Biochemistry, Molecular Biology</topic><topic>Causality</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Sacroiliac Joint - diagnostic imaging</topic><topic>Spondylarthritis - diagnostic imaging</topic><topic>Spondylarthritis - epidemiology</topic><topic>Spondyloarthritis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dougados, Maxime</creatorcontrib><creatorcontrib>Demattei, Christophe</creatorcontrib><creatorcontrib>van den Berg, Rosaline</creatorcontrib><creatorcontrib>Vo Hoang, Viet</creatorcontrib><creatorcontrib>Thevenin, Fabrice</creatorcontrib><creatorcontrib>Reijnierse, Monique</creatorcontrib><creatorcontrib>Loeuille, Damien</creatorcontrib><creatorcontrib>Feydy, Antoine</creatorcontrib><creatorcontrib>Claudepierre, Pascal</creatorcontrib><creatorcontrib>van der Heijde, Désirée</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dougados, Maxime</au><au>Demattei, Christophe</au><au>van den Berg, Rosaline</au><au>Vo Hoang, Viet</au><au>Thevenin, Fabrice</au><au>Reijnierse, Monique</au><au>Loeuille, Damien</au><au>Feydy, Antoine</au><au>Claudepierre, Pascal</au><au>van der Heijde, Désirée</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rate and Predisposing Factors for Sacroiliac Joint Radiographic Progression After a Two‐Year Follow‐up Period in Recent‐Onset Spondyloarthritis</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis Rheumatol</addtitle><date>2016-08</date><risdate>2016</risdate><volume>68</volume><issue>8</issue><spage>1904</spage><epage>1913</epage><pages>1904-1913</pages><issn>2326-5191</issn><issn>2326-5205</issn><eissn>2326-5205</eissn><eissn>2326-5191</eissn><abstract>Objective
To evaluate the rate of radiographic structural progression in the sacroiliac (SI) joints in patients with radiographic or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing to such progression, over 2 years.
Methods
Patients with recent‐onset axial SpA (from the Devenir des Spondyloarthropathies Indifferérenciées Récentes cohort) were assigned a radiographic SI joint score according to the modified New York criteria. Demographic characteristics, smoking status, HLA–B27 positivity, inflammation on magnetic resonance imaging (MRI) of the SI joints, disease activity, and treatment were investigated as potential predisposing factors. The main analysis consisted of the evaluation of the switch from nonradiographic to radiographic axial SpA, but other definitions of radiographic progression were also evaluated.
Results
Of the 708 patients enrolled, 449 had baseline and 2‐year pelvic radiographs. Of these patients, 47% were men. Their mean ± SD age was 34 ± 9 years, 61% were B27 positive, and 37% had inflammation of the SI joints on MRI. The percentages of patients who switched from nonradiographic to radiographic axial SpA (4.9% [16 of 326]) and from radiographic to nonradiographic axial SpA (5.7% [7 of 123]) were low. The mean ± SD change in the total SI joint score (range 0–8) was small (0.1 ± 0.8) but highly significant (P < 0.001). The potential baseline predisposing factors for meeting the modified New York criteria in the multivariate analysis were current smoking, HLA–B27 positivity, and inflammation of the SI joints on MRI, with odds ratios of 3.3 (95% confidence interval [95% CI] 1.0–11.5], 12.6 (95% CI 2.3–274), and 48.8 (95% CI 9.3–904), respectively.
Conclusion
Our findings suggest that structural progression does exist in early SpA, but it is quite small and observed in a small number of patients, and that environmental (smoking status), genetic (HLA–B27 positivity), and inflammation (inflammation of the SI joints on MRI) markers might be independent predisposing factors for progression.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26990518</pmid><doi>10.1002/art.39666</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3009-6229</orcidid><orcidid>https://orcid.org/0000-0001-8204-5701</orcidid><orcidid>https://orcid.org/0000-0001-6955-9281</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Arthritis & rheumatology (Hoboken, N.J.), 2016-08, Vol.68 (8), p.1904-1913 |
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| subjects | Adult Biochemistry Biochemistry, Molecular Biology Causality Disease Progression Female Follow-Up Studies Human health and pathology Humans Life Sciences Magnetic Resonance Imaging Male Sacroiliac Joint - diagnostic imaging Spondylarthritis - diagnostic imaging Spondylarthritis - epidemiology Spondyloarthritis Time Factors |
| title | Rate and Predisposing Factors for Sacroiliac Joint Radiographic Progression After a Two‐Year Follow‐up Period in Recent‐Onset Spondyloarthritis |
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