Heterozygote Advantage of the rs3794624 Polymorphism in CYBA for Resistance to Tuberculosis in Two Chinese Populations
Phagocyte Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase complex is a key enzyme that catalyzes the production of reactive oxygen species, which mediate oxygen-dependent killing of microorganisms, such as Mycobacterium tuberculosis . P22phox, encoded by CYBA , is the key regulatory subu...
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description | Phagocyte Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase complex is a key enzyme that catalyzes the production of reactive oxygen species, which mediate oxygen-dependent killing of microorganisms, such as
Mycobacterium tuberculosis
. P22phox, encoded by
CYBA
, is the key regulatory subunit of NADPH oxidase. Our study aimed to investigate the association of
CYBA
polymorphisms with susceptibility to tuberculosis. Three SNPs (rs9932581, rs3794624 and rs4673) were genotyped in the discovery cohort composed of Chinese Han individuals. We found that the A allele of rs3794624 was a significant protective factor against tuberculosis (GA vs. GG: OR = 0.74, 95% CI 0.57–0.96; GA vs. GG+AA: OR = 0.73, 95% CI 0.56–0.95), which was then replicated in the Chinese Tibetan population (GA vs. GG: OR = 0.68, 95% CI 0.51–0.92; AA+GA vs. GG: OR = 0.70, 95% CI 0.52–0.93; GA vs. GG+AA: OR = 0.68, 95% CI 0.51–0.92). Meta-analysis including both cohorts identified overdominance as the best genetic model and provided robust evidence for the protective effect of the rs3794624 GA genotype against tuberculosis without any evidence of heterogeneity (GA vs. GG+AA: OR = 0.71, 95% CI 0.58–0.86). Our study found an association between the GA genotype of rs3794624 in
CYBA
with decreased tuberculosis susceptibility in two Chinese populations. Further analyses are needed to reveal the potential function of this SNP. |
doi_str_mv | 10.1038/srep38213 |
format | Article |
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Mycobacterium tuberculosis
. P22phox, encoded by
CYBA
, is the key regulatory subunit of NADPH oxidase. Our study aimed to investigate the association of
CYBA
polymorphisms with susceptibility to tuberculosis. Three SNPs (rs9932581, rs3794624 and rs4673) were genotyped in the discovery cohort composed of Chinese Han individuals. We found that the A allele of rs3794624 was a significant protective factor against tuberculosis (GA vs. GG: OR = 0.74, 95% CI 0.57–0.96; GA vs. GG+AA: OR = 0.73, 95% CI 0.56–0.95), which was then replicated in the Chinese Tibetan population (GA vs. GG: OR = 0.68, 95% CI 0.51–0.92; AA+GA vs. GG: OR = 0.70, 95% CI 0.52–0.93; GA vs. GG+AA: OR = 0.68, 95% CI 0.51–0.92). Meta-analysis including both cohorts identified overdominance as the best genetic model and provided robust evidence for the protective effect of the rs3794624 GA genotype against tuberculosis without any evidence of heterogeneity (GA vs. GG+AA: OR = 0.71, 95% CI 0.58–0.86). Our study found an association between the GA genotype of rs3794624 in
CYBA
with decreased tuberculosis susceptibility in two Chinese populations. Further analyses are needed to reveal the potential function of this SNP.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep38213</identifier><identifier>PMID: 27901128</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/77 ; 692/308/2056 ; 692/699/255 ; 82/58 ; Adult ; Alleles ; Asian People - genetics ; China ; Female ; Gene Frequency ; Genetic Predisposition to Disease - ethnology ; Genetic Predisposition to Disease - genetics ; Genotype ; Heterogeneity ; Heterozygote ; Heterozygote advantage ; Humanities and Social Sciences ; Humans ; Male ; Microorganisms ; Middle Aged ; multidisciplinary ; NAD(P)H oxidase ; NADPH Oxidases - genetics ; NADPH-diaphorase ; Oxidation ; Polymorphism, Single Nucleotide ; Reactive oxygen species ; Science ; Single-nucleotide polymorphism ; Tuberculosis ; Tuberculosis - ethnology ; Tuberculosis - genetics ; Young Adult</subject><ispartof>Scientific reports, 2016-11, Vol.6 (1), p.38213-38213, Article 38213</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Nov 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-813d7e9a2a022e1e9c4d9a3bf15efc303a936a79110f90bc62e6bfde983fed633</citedby><cites>FETCH-LOGICAL-c504t-813d7e9a2a022e1e9c4d9a3bf15efc303a936a79110f90bc62e6bfde983fed633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128811/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128811/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27928,27929,41124,42193,51580,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27901128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Qianqian</creatorcontrib><creatorcontrib>Wu, Shouquan</creatorcontrib><creatorcontrib>Xue, Miao</creatorcontrib><creatorcontrib>Sandford, Andrew J.</creatorcontrib><creatorcontrib>Wu, Jingcan</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Chen, Guo</creatorcontrib><creatorcontrib>Tao, Chuanmin</creatorcontrib><creatorcontrib>Tang, Yin</creatorcontrib><creatorcontrib>Feng, Yulin</creatorcontrib><creatorcontrib>Luo, Jun</creatorcontrib><creatorcontrib>He, Jian-Qing</creatorcontrib><title>Heterozygote Advantage of the rs3794624 Polymorphism in CYBA for Resistance to Tuberculosis in Two Chinese Populations</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Phagocyte Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase complex is a key enzyme that catalyzes the production of reactive oxygen species, which mediate oxygen-dependent killing of microorganisms, such as
Mycobacterium tuberculosis
. P22phox, encoded by
CYBA
, is the key regulatory subunit of NADPH oxidase. Our study aimed to investigate the association of
CYBA
polymorphisms with susceptibility to tuberculosis. Three SNPs (rs9932581, rs3794624 and rs4673) were genotyped in the discovery cohort composed of Chinese Han individuals. We found that the A allele of rs3794624 was a significant protective factor against tuberculosis (GA vs. GG: OR = 0.74, 95% CI 0.57–0.96; GA vs. GG+AA: OR = 0.73, 95% CI 0.56–0.95), which was then replicated in the Chinese Tibetan population (GA vs. GG: OR = 0.68, 95% CI 0.51–0.92; AA+GA vs. GG: OR = 0.70, 95% CI 0.52–0.93; GA vs. GG+AA: OR = 0.68, 95% CI 0.51–0.92). Meta-analysis including both cohorts identified overdominance as the best genetic model and provided robust evidence for the protective effect of the rs3794624 GA genotype against tuberculosis without any evidence of heterogeneity (GA vs. GG+AA: OR = 0.71, 95% CI 0.58–0.86). Our study found an association between the GA genotype of rs3794624 in
CYBA
with decreased tuberculosis susceptibility in two Chinese populations. Further analyses are needed to reveal the potential function of this SNP.</description><subject>45/77</subject><subject>692/308/2056</subject><subject>692/699/255</subject><subject>82/58</subject><subject>Adult</subject><subject>Alleles</subject><subject>Asian People - genetics</subject><subject>China</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease - ethnology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Heterogeneity</subject><subject>Heterozygote</subject><subject>Heterozygote advantage</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Microorganisms</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>NAD(P)H oxidase</subject><subject>NADPH Oxidases - genetics</subject><subject>NADPH-diaphorase</subject><subject>Oxidation</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Reactive oxygen species</subject><subject>Science</subject><subject>Single-nucleotide polymorphism</subject><subject>Tuberculosis</subject><subject>Tuberculosis - ethnology</subject><subject>Tuberculosis - genetics</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkU9rGzEQxUVpaUKaQ79AEfTSFJzqz-56dSk4pm0CgZTgHHoSWu3IVtiVNpLWwfn0lXFqnFSXEZofb57mIfSRknNKeP0tBhh4zSh_g44ZKcoJ44y9PbgfodMY70k-JRMFFe_REZsKQimrj9H6EhIE_7RZ-gR41q6VS2oJ2BucVoBD5FNRVKzAv3236X0YVjb22Do8_3Mxw8YHfAvRxqScBpw8XowNBD12Pj9uscWjx_OVdRAhSwxjp5L1Ln5A74zqIpw-1xN09_PHYn45ub75dTWfXU90SYo0qSlvpyAUU4QxoCB00QrFG0NLMJoTrgSv1FRQSowgja4YVI1pQdTcQFtxfoK-73SHsemh1eBSUJ0cgu1V2EivrHzZcXYll34ty7ydmtIs8OVZIPiHEWKSvY0auk458GOUtC5KVhJabdHPr9B7PwaXv5cpkY0yQqpMne0oHXzM2Zm9GUrkNlC5DzSznw7d78l_8WXg6w6IueWWEA5G_qf2F3kxqt4</recordid><startdate>20161130</startdate><enddate>20161130</enddate><creator>Liu, Qianqian</creator><creator>Wu, Shouquan</creator><creator>Xue, Miao</creator><creator>Sandford, Andrew J.</creator><creator>Wu, Jingcan</creator><creator>Wang, Yu</creator><creator>Chen, Guo</creator><creator>Tao, Chuanmin</creator><creator>Tang, Yin</creator><creator>Feng, Yulin</creator><creator>Luo, Jun</creator><creator>He, Jian-Qing</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161130</creationdate><title>Heterozygote Advantage of the rs3794624 Polymorphism in CYBA for Resistance to Tuberculosis in Two Chinese Populations</title><author>Liu, Qianqian ; Wu, Shouquan ; Xue, Miao ; Sandford, Andrew J. ; Wu, Jingcan ; Wang, Yu ; Chen, Guo ; Tao, Chuanmin ; Tang, Yin ; Feng, Yulin ; Luo, Jun ; He, Jian-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-813d7e9a2a022e1e9c4d9a3bf15efc303a936a79110f90bc62e6bfde983fed633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>45/77</topic><topic>692/308/2056</topic><topic>692/699/255</topic><topic>82/58</topic><topic>Adult</topic><topic>Alleles</topic><topic>Asian People - genetics</topic><topic>China</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease - ethnology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Heterogeneity</topic><topic>Heterozygote</topic><topic>Heterozygote advantage</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Microorganisms</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>NAD(P)H oxidase</topic><topic>NADPH Oxidases - genetics</topic><topic>NADPH-diaphorase</topic><topic>Oxidation</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Reactive oxygen species</topic><topic>Science</topic><topic>Single-nucleotide polymorphism</topic><topic>Tuberculosis</topic><topic>Tuberculosis - ethnology</topic><topic>Tuberculosis - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Qianqian</creatorcontrib><creatorcontrib>Wu, Shouquan</creatorcontrib><creatorcontrib>Xue, Miao</creatorcontrib><creatorcontrib>Sandford, Andrew J.</creatorcontrib><creatorcontrib>Wu, Jingcan</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Chen, Guo</creatorcontrib><creatorcontrib>Tao, Chuanmin</creatorcontrib><creatorcontrib>Tang, Yin</creatorcontrib><creatorcontrib>Feng, Yulin</creatorcontrib><creatorcontrib>Luo, Jun</creatorcontrib><creatorcontrib>He, Jian-Qing</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Qianqian</au><au>Wu, Shouquan</au><au>Xue, Miao</au><au>Sandford, Andrew J.</au><au>Wu, Jingcan</au><au>Wang, Yu</au><au>Chen, Guo</au><au>Tao, Chuanmin</au><au>Tang, Yin</au><au>Feng, Yulin</au><au>Luo, Jun</au><au>He, Jian-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterozygote Advantage of the rs3794624 Polymorphism in CYBA for Resistance to Tuberculosis in Two Chinese Populations</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-11-30</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>38213</spage><epage>38213</epage><pages>38213-38213</pages><artnum>38213</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Phagocyte Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase complex is a key enzyme that catalyzes the production of reactive oxygen species, which mediate oxygen-dependent killing of microorganisms, such as
Mycobacterium tuberculosis
. P22phox, encoded by
CYBA
, is the key regulatory subunit of NADPH oxidase. Our study aimed to investigate the association of
CYBA
polymorphisms with susceptibility to tuberculosis. Three SNPs (rs9932581, rs3794624 and rs4673) were genotyped in the discovery cohort composed of Chinese Han individuals. We found that the A allele of rs3794624 was a significant protective factor against tuberculosis (GA vs. GG: OR = 0.74, 95% CI 0.57–0.96; GA vs. GG+AA: OR = 0.73, 95% CI 0.56–0.95), which was then replicated in the Chinese Tibetan population (GA vs. GG: OR = 0.68, 95% CI 0.51–0.92; AA+GA vs. GG: OR = 0.70, 95% CI 0.52–0.93; GA vs. GG+AA: OR = 0.68, 95% CI 0.51–0.92). Meta-analysis including both cohorts identified overdominance as the best genetic model and provided robust evidence for the protective effect of the rs3794624 GA genotype against tuberculosis without any evidence of heterogeneity (GA vs. GG+AA: OR = 0.71, 95% CI 0.58–0.86). Our study found an association between the GA genotype of rs3794624 in
CYBA
with decreased tuberculosis susceptibility in two Chinese populations. Further analyses are needed to reveal the potential function of this SNP.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27901128</pmid><doi>10.1038/srep38213</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 45/77 692/308/2056 692/699/255 82/58 Adult Alleles Asian People - genetics China Female Gene Frequency Genetic Predisposition to Disease - ethnology Genetic Predisposition to Disease - genetics Genotype Heterogeneity Heterozygote Heterozygote advantage Humanities and Social Sciences Humans Male Microorganisms Middle Aged multidisciplinary NAD(P)H oxidase NADPH Oxidases - genetics NADPH-diaphorase Oxidation Polymorphism, Single Nucleotide Reactive oxygen species Science Single-nucleotide polymorphism Tuberculosis Tuberculosis - ethnology Tuberculosis - genetics Young Adult |
title | Heterozygote Advantage of the rs3794624 Polymorphism in CYBA for Resistance to Tuberculosis in Two Chinese Populations |
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