Distal Stereocontrol Using Guanidinylated Peptides as Multifunctional Ligands: Desymmetrization of Diarylmethanes via Ullman Cross-Coupling

We report the development of a new class of guanidine-containing peptides as multifunctional ligands for transition-metal catalysis and its application in the remote desymmetrization of diarylmethanes via copper-catalyzed Ullman cross-coupling. Through design of these peptides, high levels of enanti...

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Veröffentlicht in:	Journal of the American Chemical Society 2016-06, Vol.138 (25), p.7939-7945
Hauptverfasser:	Kim, Byoungmoo, Chinn, Alex J, Fandrick, Daniel R, Senanayake, Chris H, Singer, Robert A, Miller, Scott J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bromides - chemistry Catalysis Chemistry, Organic - methods Copper - chemistry Kinetics Ligands Magnetic Resonance Spectroscopy Malonates - chemistry Metals - chemistry Methane - chemistry Molecular Structure Peptides - chemistry Protein Binding Protein Domains Stereoisomerism
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