Association between epithelial‐mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma
The epithelial‐mesenchymal transition (EMT) and cancer stemness (CS) are reported to be pivotal phenomena involved in metastasis, recurrence, and drug‐resistance in lung cancer; however, their effects on tumor malignancy in clinical settings are not completely understood. The mutual association betw...
Gespeichert in:
| Veröffentlicht in: | Cancer medicine (Malden, MA) MA), 2015-12, Vol.4 (12), p.1853-1862 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1862 |
|---|---|
| container_issue | 12 |
| container_start_page | 1853 |
| container_title | Cancer medicine (Malden, MA) |
| container_volume | 4 |
| creator | Sowa, Terumasa Menju, Toshi Sonobe, Makoto Nakanishi, Takao Shikuma, Kei Imamura, Naoto Motoyama, Hideki Hijiya, Kyoko Aoyama, Akihiro Chen, Fengshi Sato, Toshihiko Kobayashi, Masashi Yoshizawa, Akihiko Haga, Hironori Sozu, Takashi Date, Hiroshi |
| description | The epithelial‐mesenchymal transition (EMT) and cancer stemness (CS) are reported to be pivotal phenomena involved in metastasis, recurrence, and drug‐resistance in lung cancer; however, their effects on tumor malignancy in clinical settings are not completely understood. The mutual association between these factors also remains elusive and are worthy of investigation. The purpose of this study was to elucidate the association between EMT and CS, and their effect on the prognosis of patients with lung adenocarcinoma. A total of 239 lung adenocarcinoma specimens were collected from patients who had undergone surgery at Kyoto University Hospital from January 2001 to December 2007. Both EMT (E‐cadherin,vimentin) and CS (CD133, CD44, aldehyde dehydrogenase) markers were analyzed through immunostaining of tumor specimens. The association between EMT and CS as well as the patients' clinical information was integrated and statistically analyzed. The molecular expression of E‐cadherin, vimentin, and CD133 were significantly correlated with prognosis (P = 0.003, P = 0.005, and P |
| doi_str_mv | 10.1002/cam4.556 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5123719</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2289730670</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4826-da73d633b7693ff69f08ced41c68fca3aee2b6f152c7ff9925a4b0b75a0f3b013</originalsourceid><addsrcrecordid>eNp1kctu1DAUhiMEolWpxBMgS2zYpPiS2M4GaTTiJhWxgbV14hzPuErswU6oZseCB-gz9knwtKUUJLzx7TufztFfVc8ZPWOU8tcWpuasbeWj6pjTpq2VFM3jB-ej6jTnC1qWolwq9rQ64rJRTEt9XP1c5Ryth9nHQHqcLxEDwZ2ftzh6GK9_XE2YMdjtfoKRzAlC9jcshIFYCBYTyTNOAXO-eSuFPhF0Du1MClfuZJfiJsTsM4mOjEvYEBgwRAvJ-hAneFY9cTBmPL3bT6qv795-WX-ozz-__7hende20VzWAygxSCF6JTvhnOwc1RaHhlmpnQUBiLyXjrXcKue6jrfQ9LRXLVAnesrESfXm1rtb-gkHi6EMNJpd8hOkvYngzd8_wW_NJn43LeNCsa4IXt0JUvy2YJ7N5LPFcYSAccmGKUm11qoRBX35D3oRlxTKeIZz3SlBpaJ_hDbFnBO6-2YYNYd0zSFdU9It6IuHzd-Dv7MsQH0LXPoR9_8VmfXqU3MQ_gIIQLLb</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2289730670</pqid></control><display><type>article</type><title>Association between epithelial‐mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma</title><source>MEDLINE</source><source>Wiley Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Sowa, Terumasa ; Menju, Toshi ; Sonobe, Makoto ; Nakanishi, Takao ; Shikuma, Kei ; Imamura, Naoto ; Motoyama, Hideki ; Hijiya, Kyoko ; Aoyama, Akihiro ; Chen, Fengshi ; Sato, Toshihiko ; Kobayashi, Masashi ; Yoshizawa, Akihiko ; Haga, Hironori ; Sozu, Takashi ; Date, Hiroshi</creator><creatorcontrib>Sowa, Terumasa ; Menju, Toshi ; Sonobe, Makoto ; Nakanishi, Takao ; Shikuma, Kei ; Imamura, Naoto ; Motoyama, Hideki ; Hijiya, Kyoko ; Aoyama, Akihiro ; Chen, Fengshi ; Sato, Toshihiko ; Kobayashi, Masashi ; Yoshizawa, Akihiko ; Haga, Hironori ; Sozu, Takashi ; Date, Hiroshi</creatorcontrib><description>The epithelial‐mesenchymal transition (EMT) and cancer stemness (CS) are reported to be pivotal phenomena involved in metastasis, recurrence, and drug‐resistance in lung cancer; however, their effects on tumor malignancy in clinical settings are not completely understood. The mutual association between these factors also remains elusive and are worthy of investigation. The purpose of this study was to elucidate the association between EMT and CS, and their effect on the prognosis of patients with lung adenocarcinoma. A total of 239 lung adenocarcinoma specimens were collected from patients who had undergone surgery at Kyoto University Hospital from January 2001 to December 2007. Both EMT (E‐cadherin,vimentin) and CS (CD133, CD44, aldehyde dehydrogenase) markers were analyzed through immunostaining of tumor specimens. The association between EMT and CS as well as the patients' clinical information was integrated and statistically analyzed. The molecular expression of E‐cadherin, vimentin, and CD133 were significantly correlated with prognosis (P = 0.003, P = 0.005, and P < 0.001). A negative correlation was found between E‐cadherin and vimentin expression (P < 0.001), whereas, a positive correlation was found between vimentin and CD133 expression (P = 0.020). CD133 was a stronger prognostic factor than an EMT marker. Elevated CD133 expression is the signature marker of EMT and CS association in lung adenocarcinoma. EMT and CS are associated in lung adenocarcinoma. Importantly, CD133 is suggested to be the key factor that links EMT and CS, thereby exacerbating tumor progression.
Epithelial‐mesenchymal transition (EMT) and cancer stemness (CS) are associated in lung adenocarcinoma. CD133 and vimentin are the key factor that links EMT and CS, thereby exacerbating patients' prognoses.</description><identifier>ISSN: 2045-7634</identifier><identifier>EISSN: 2045-7634</identifier><identifier>DOI: 10.1002/cam4.556</identifier><identifier>PMID: 26471868</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Adenocarcinoma of Lung ; Adult ; Aged ; Aged, 80 and over ; Aldehyde dehydrogenase ; Biomarkers ; Brain cancer ; Cancer stemness ; Cancer therapies ; CD133 ; CD44 antigen ; Cell adhesion & migration ; Classification ; Clinical Cancer Research ; Colorectal cancer ; Epithelial-Mesenchymal Transition ; Female ; Humans ; Hypoxia ; Kaplan-Meier Estimate ; lung adenocarcinoma ; Lung cancer ; Lung Neoplasms - metabolism ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Malignancy ; Medical prognosis ; Mesenchyme ; Metastases ; Metastasis ; Middle Aged ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Neoplastic Stem Cells - metabolism ; Original Research ; Pancreatic cancer ; Patients ; Prognosis ; Proportional Hazards Models ; Risk Factors ; Stem cells ; Studies ; Surgery ; Tumors ; Vimentin ; Young Adult</subject><ispartof>Cancer medicine (Malden, MA), 2015-12, Vol.4 (12), p.1853-1862</ispartof><rights>2015 The Author. published by John Wiley & Sons Ltd.</rights><rights>2015 The Author. Cancer Medicine published by John Wiley & Sons Ltd.</rights><rights>2015. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4826-da73d633b7693ff69f08ced41c68fca3aee2b6f152c7ff9925a4b0b75a0f3b013</citedby><cites>FETCH-LOGICAL-c4826-da73d633b7693ff69f08ced41c68fca3aee2b6f152c7ff9925a4b0b75a0f3b013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123719/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123719/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26471868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sowa, Terumasa</creatorcontrib><creatorcontrib>Menju, Toshi</creatorcontrib><creatorcontrib>Sonobe, Makoto</creatorcontrib><creatorcontrib>Nakanishi, Takao</creatorcontrib><creatorcontrib>Shikuma, Kei</creatorcontrib><creatorcontrib>Imamura, Naoto</creatorcontrib><creatorcontrib>Motoyama, Hideki</creatorcontrib><creatorcontrib>Hijiya, Kyoko</creatorcontrib><creatorcontrib>Aoyama, Akihiro</creatorcontrib><creatorcontrib>Chen, Fengshi</creatorcontrib><creatorcontrib>Sato, Toshihiko</creatorcontrib><creatorcontrib>Kobayashi, Masashi</creatorcontrib><creatorcontrib>Yoshizawa, Akihiko</creatorcontrib><creatorcontrib>Haga, Hironori</creatorcontrib><creatorcontrib>Sozu, Takashi</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><title>Association between epithelial‐mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma</title><title>Cancer medicine (Malden, MA)</title><addtitle>Cancer Med</addtitle><description>The epithelial‐mesenchymal transition (EMT) and cancer stemness (CS) are reported to be pivotal phenomena involved in metastasis, recurrence, and drug‐resistance in lung cancer; however, their effects on tumor malignancy in clinical settings are not completely understood. The mutual association between these factors also remains elusive and are worthy of investigation. The purpose of this study was to elucidate the association between EMT and CS, and their effect on the prognosis of patients with lung adenocarcinoma. A total of 239 lung adenocarcinoma specimens were collected from patients who had undergone surgery at Kyoto University Hospital from January 2001 to December 2007. Both EMT (E‐cadherin,vimentin) and CS (CD133, CD44, aldehyde dehydrogenase) markers were analyzed through immunostaining of tumor specimens. The association between EMT and CS as well as the patients' clinical information was integrated and statistically analyzed. The molecular expression of E‐cadherin, vimentin, and CD133 were significantly correlated with prognosis (P = 0.003, P = 0.005, and P < 0.001). A negative correlation was found between E‐cadherin and vimentin expression (P < 0.001), whereas, a positive correlation was found between vimentin and CD133 expression (P = 0.020). CD133 was a stronger prognostic factor than an EMT marker. Elevated CD133 expression is the signature marker of EMT and CS association in lung adenocarcinoma. EMT and CS are associated in lung adenocarcinoma. Importantly, CD133 is suggested to be the key factor that links EMT and CS, thereby exacerbating tumor progression.
Epithelial‐mesenchymal transition (EMT) and cancer stemness (CS) are associated in lung adenocarcinoma. CD133 and vimentin are the key factor that links EMT and CS, thereby exacerbating patients' prognoses.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Adenocarcinoma of Lung</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aldehyde dehydrogenase</subject><subject>Biomarkers</subject><subject>Brain cancer</subject><subject>Cancer stemness</subject><subject>Cancer therapies</subject><subject>CD133</subject><subject>CD44 antigen</subject><subject>Cell adhesion & migration</subject><subject>Classification</subject><subject>Clinical Cancer Research</subject><subject>Colorectal cancer</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Kaplan-Meier Estimate</subject><subject>lung adenocarcinoma</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical prognosis</subject><subject>Mesenchyme</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Original Research</subject><subject>Pancreatic cancer</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Vimentin</subject><subject>Young Adult</subject><issn>2045-7634</issn><issn>2045-7634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctu1DAUhiMEolWpxBMgS2zYpPiS2M4GaTTiJhWxgbV14hzPuErswU6oZseCB-gz9knwtKUUJLzx7TufztFfVc8ZPWOU8tcWpuasbeWj6pjTpq2VFM3jB-ej6jTnC1qWolwq9rQ64rJRTEt9XP1c5Ryth9nHQHqcLxEDwZ2ftzh6GK9_XE2YMdjtfoKRzAlC9jcshIFYCBYTyTNOAXO-eSuFPhF0Du1MClfuZJfiJsTsM4mOjEvYEBgwRAvJ-hAneFY9cTBmPL3bT6qv795-WX-ozz-__7hende20VzWAygxSCF6JTvhnOwc1RaHhlmpnQUBiLyXjrXcKue6jrfQ9LRXLVAnesrESfXm1rtb-gkHi6EMNJpd8hOkvYngzd8_wW_NJn43LeNCsa4IXt0JUvy2YJ7N5LPFcYSAccmGKUm11qoRBX35D3oRlxTKeIZz3SlBpaJ_hDbFnBO6-2YYNYd0zSFdU9It6IuHzd-Dv7MsQH0LXPoR9_8VmfXqU3MQ_gIIQLLb</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Sowa, Terumasa</creator><creator>Menju, Toshi</creator><creator>Sonobe, Makoto</creator><creator>Nakanishi, Takao</creator><creator>Shikuma, Kei</creator><creator>Imamura, Naoto</creator><creator>Motoyama, Hideki</creator><creator>Hijiya, Kyoko</creator><creator>Aoyama, Akihiro</creator><creator>Chen, Fengshi</creator><creator>Sato, Toshihiko</creator><creator>Kobayashi, Masashi</creator><creator>Yoshizawa, Akihiko</creator><creator>Haga, Hironori</creator><creator>Sozu, Takashi</creator><creator>Date, Hiroshi</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201512</creationdate><title>Association between epithelial‐mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma</title><author>Sowa, Terumasa ; Menju, Toshi ; Sonobe, Makoto ; Nakanishi, Takao ; Shikuma, Kei ; Imamura, Naoto ; Motoyama, Hideki ; Hijiya, Kyoko ; Aoyama, Akihiro ; Chen, Fengshi ; Sato, Toshihiko ; Kobayashi, Masashi ; Yoshizawa, Akihiko ; Haga, Hironori ; Sozu, Takashi ; Date, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4826-da73d633b7693ff69f08ced41c68fca3aee2b6f152c7ff9925a4b0b75a0f3b013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Adenocarcinoma of Lung</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aldehyde dehydrogenase</topic><topic>Biomarkers</topic><topic>Brain cancer</topic><topic>Cancer stemness</topic><topic>Cancer therapies</topic><topic>CD133</topic><topic>CD44 antigen</topic><topic>Cell adhesion & migration</topic><topic>Classification</topic><topic>Clinical Cancer Research</topic><topic>Colorectal cancer</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Kaplan-Meier Estimate</topic><topic>lung adenocarcinoma</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical prognosis</topic><topic>Mesenchyme</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Original Research</topic><topic>Pancreatic cancer</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Vimentin</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sowa, Terumasa</creatorcontrib><creatorcontrib>Menju, Toshi</creatorcontrib><creatorcontrib>Sonobe, Makoto</creatorcontrib><creatorcontrib>Nakanishi, Takao</creatorcontrib><creatorcontrib>Shikuma, Kei</creatorcontrib><creatorcontrib>Imamura, Naoto</creatorcontrib><creatorcontrib>Motoyama, Hideki</creatorcontrib><creatorcontrib>Hijiya, Kyoko</creatorcontrib><creatorcontrib>Aoyama, Akihiro</creatorcontrib><creatorcontrib>Chen, Fengshi</creatorcontrib><creatorcontrib>Sato, Toshihiko</creatorcontrib><creatorcontrib>Kobayashi, Masashi</creatorcontrib><creatorcontrib>Yoshizawa, Akihiko</creatorcontrib><creatorcontrib>Haga, Hironori</creatorcontrib><creatorcontrib>Sozu, Takashi</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer medicine (Malden, MA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sowa, Terumasa</au><au>Menju, Toshi</au><au>Sonobe, Makoto</au><au>Nakanishi, Takao</au><au>Shikuma, Kei</au><au>Imamura, Naoto</au><au>Motoyama, Hideki</au><au>Hijiya, Kyoko</au><au>Aoyama, Akihiro</au><au>Chen, Fengshi</au><au>Sato, Toshihiko</au><au>Kobayashi, Masashi</au><au>Yoshizawa, Akihiko</au><au>Haga, Hironori</au><au>Sozu, Takashi</au><au>Date, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between epithelial‐mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma</atitle><jtitle>Cancer medicine (Malden, MA)</jtitle><addtitle>Cancer Med</addtitle><date>2015-12</date><risdate>2015</risdate><volume>4</volume><issue>12</issue><spage>1853</spage><epage>1862</epage><pages>1853-1862</pages><issn>2045-7634</issn><eissn>2045-7634</eissn><abstract>The epithelial‐mesenchymal transition (EMT) and cancer stemness (CS) are reported to be pivotal phenomena involved in metastasis, recurrence, and drug‐resistance in lung cancer; however, their effects on tumor malignancy in clinical settings are not completely understood. The mutual association between these factors also remains elusive and are worthy of investigation. The purpose of this study was to elucidate the association between EMT and CS, and their effect on the prognosis of patients with lung adenocarcinoma. A total of 239 lung adenocarcinoma specimens were collected from patients who had undergone surgery at Kyoto University Hospital from January 2001 to December 2007. Both EMT (E‐cadherin,vimentin) and CS (CD133, CD44, aldehyde dehydrogenase) markers were analyzed through immunostaining of tumor specimens. The association between EMT and CS as well as the patients' clinical information was integrated and statistically analyzed. The molecular expression of E‐cadherin, vimentin, and CD133 were significantly correlated with prognosis (P = 0.003, P = 0.005, and P < 0.001). A negative correlation was found between E‐cadherin and vimentin expression (P < 0.001), whereas, a positive correlation was found between vimentin and CD133 expression (P = 0.020). CD133 was a stronger prognostic factor than an EMT marker. Elevated CD133 expression is the signature marker of EMT and CS association in lung adenocarcinoma. EMT and CS are associated in lung adenocarcinoma. Importantly, CD133 is suggested to be the key factor that links EMT and CS, thereby exacerbating tumor progression.
Epithelial‐mesenchymal transition (EMT) and cancer stemness (CS) are associated in lung adenocarcinoma. CD133 and vimentin are the key factor that links EMT and CS, thereby exacerbating patients' prognoses.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>26471868</pmid><doi>10.1002/cam4.556</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-7634 |
| ispartof | Cancer medicine (Malden, MA), 2015-12, Vol.4 (12), p.1853-1862 |
| issn | 2045-7634 2045-7634 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5123719 |
| source | MEDLINE; Wiley Journals; DOAJ Directory of Open Access Journals; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adenocarcinoma Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Adenocarcinoma of Lung Adult Aged Aged, 80 and over Aldehyde dehydrogenase Biomarkers Brain cancer Cancer stemness Cancer therapies CD133 CD44 antigen Cell adhesion & migration Classification Clinical Cancer Research Colorectal cancer Epithelial-Mesenchymal Transition Female Humans Hypoxia Kaplan-Meier Estimate lung adenocarcinoma Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - surgery Male Malignancy Medical prognosis Mesenchyme Metastases Metastasis Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplasm Staging Neoplastic Stem Cells - metabolism Original Research Pancreatic cancer Patients Prognosis Proportional Hazards Models Risk Factors Stem cells Studies Surgery Tumors Vimentin Young Adult |
| title | Association between epithelial‐mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T14%3A09%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20epithelial%E2%80%90mesenchymal%20transition%20and%20cancer%20stemness%20and%20their%20effect%20on%20the%20prognosis%20of%20lung%20adenocarcinoma&rft.jtitle=Cancer%20medicine%20(Malden,%20MA)&rft.au=Sowa,%20Terumasa&rft.date=2015-12&rft.volume=4&rft.issue=12&rft.spage=1853&rft.epage=1862&rft.pages=1853-1862&rft.issn=2045-7634&rft.eissn=2045-7634&rft_id=info:doi/10.1002/cam4.556&rft_dat=%3Cproquest_pubme%3E2289730670%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2289730670&rft_id=info:pmid/26471868&rfr_iscdi=true |