A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

Helminth parasites secrete molecules that potently modulate the immune responses of their hosts and, therefore, have potential for the treatment of immune-mediated human diseases. FhHDM-1, a 68-mer peptide secreted by the helminth parasite Fasciola hepatica, ameliorated disease in two different muri...

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Veröffentlicht in:	Scientific reports 2016-11, Vol.6 (1), p.37789-37789, Article 37789
Hauptverfasser:	Lund, Maria E., Greer, Judith, Dixit, Aakanksha, Alvarado, Raquel, McCauley-Winter, Padraig, To, Joyce, Tanaka, Akane, Hutchinson, Andrew T., Robinson, Mark W., Simpson, Ann M., O’Brien, Bronwyn A., Dalton, John P., Donnelly, Sheila
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/21 13/31 631/250/38 631/326/417/2547 Animal models Animals Autoimmune diseases Autoimmune Diseases - immunology Autoimmunity - immunology Cell proliferation Cell Proliferation - physiology Cytokines Cytokines - immunology Demyelination Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - immunology Disease Disease Models, Animal Fasciola hepatica - immunology Female Helminth Proteins - immunology Humanities and Social Sciences Immune response Inflammation Inflammation - immunology Interleukin 6 Interleukin-6 - immunology Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Mice Mice, Inbred BALB C multidisciplinary Multiple sclerosis Multiple Sclerosis - immunology Parasites Parasites - immunology Peptides Peptides - immunology Science T cell receptors T-Lymphocytes - immunology Tumor necrosis factor
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