The structure of a doripenem‐bound OXA‐51 class D β‐lactamase variant with enhanced carbapenemase activity

OXA‐51 is a class D β‐lactamase that is thought to be the native carbapenemase of Acinetobacter baumannii. Many variants of OXA‐51 containing active site substitutions have been identified from A. baumannii isolates, and some of these substitutions increase hydrolytic activity toward carbapenem anti...

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Veröffentlicht in:	Protein science 2016-12, Vol.25 (12), p.2152-2163
Hauptverfasser:	June, Cynthia M., Muckenthaler, Taylor J., Schroder, Emma C., Klamer, Zachary L., Wawrzak, Zdzislaw, Powers, Rachel A., Szarecka, Agnieszka, Leonard, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii - enzymology Acinetobacter baumannii - genetics Amino Acid Substitution antibiotic resistance beta-Lactamases - chemistry beta-Lactamases - genetics Binding Sites carbapenem Carbapenems - chemistry crystal structure Crystallography, X-Ray Molecular Dynamics Simulation Mutation, Missense β‐lactamase
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