Circulating cathodic antigen cassette test versus haematuria strip test in diagnosis of urinary schistosomiasis
Urinary schistosomiasis caused by Schistosoma haematobium constitutes a major public health problem in many tropical and sub-tropical countries. This study was conducted to evaluate circulating cathodic antigen cassette test and haematuria strip test for detection of S. haematobium in urine samples...
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| Veröffentlicht in: | Journal of parasitic diseases 2016-12, Vol.40 (4), p.1193-1198 |
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| creator | El-Ghareeb, Azza S. Abd El Motaleb, Ghada S. Waked, Nevien Maher Osman Hany Kamel, Nancy Aly, Nagwa Shaban |
| description | Urinary schistosomiasis caused by
Schistosoma haematobium
constitutes a major public health problem in many tropical and sub-tropical countries. This study was conducted to evaluate circulating cathodic antigen cassette test and haematuria strip test for detection of
S. haematobium
in urine samples and to evaluate their screening performance among the study population. Microscopy was used as a gold standard. A total of 600 urine samples were examined by microscopy for detection of
S. haematobium
eggs, screened for microhaematuria using Self-Stik reagent strips and screened for circulating cathodic antigen (CCA) using the urine-CCA cassette test. The specificity of CCA, microhaematuria and macrohaematuria was 96.4, 40.6 and 31.2 % respectively while the sensitivity was 88.2, 99.3 and 100 % respectively which was statistically significant (P |
| doi_str_mv | 10.1007/s12639-015-0648-2 |
| format | Article |
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Schistosoma haematobium
constitutes a major public health problem in many tropical and sub-tropical countries. This study was conducted to evaluate circulating cathodic antigen cassette test and haematuria strip test for detection of
S. haematobium
in urine samples and to evaluate their screening performance among the study population. Microscopy was used as a gold standard. A total of 600 urine samples were examined by microscopy for detection of
S. haematobium
eggs, screened for microhaematuria using Self-Stik reagent strips and screened for circulating cathodic antigen (CCA) using the urine-CCA cassette test. The specificity of CCA, microhaematuria and macrohaematuria was 96.4, 40.6 and 31.2 % respectively while the sensitivity was 88.2, 99.3 and 100 % respectively which was statistically significant (P < 0.001). These findings suggest that using of urine-CCA cassette test in diagnosis of urinary schistosomiasis is highly specific (96.4 %) compared with the highly sensitive haematuria strip test (100 %). The degree of agreement between microscopic examination and CCA detection was 99.3 % with highly statistically significant difference (P < 0.001). The combination of two techniques could potentially use for screening and mapping of S.
haematobium
infection.</description><identifier>ISSN: 0971-7196</identifier><identifier>EISSN: 0975-0703</identifier><identifier>DOI: 10.1007/s12639-015-0648-2</identifier><identifier>PMID: 27876913</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Antigens ; Eggs ; Health Promotion and Disease Prevention ; Hematuria ; Infectious Diseases ; Mapping ; Medicine ; Medicine & Public Health ; Microscopy ; Original ; Original Article ; Population studies ; Public health ; Schistosoma haematobium ; Schistosomiasis ; schistosomiasis haematobia ; screening ; Statistical analysis ; Urine</subject><ispartof>Journal of parasitic diseases, 2016-12, Vol.40 (4), p.1193-1198</ispartof><rights>Indian Society for Parasitology 2015</rights><rights>Copyright Springer Science & Business Media 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4182-67ae75099c870d255e13b78774f56f235df093e72a08d4aece210a9f4708aecd3</citedby><cites>FETCH-LOGICAL-c4182-67ae75099c870d255e13b78774f56f235df093e72a08d4aece210a9f4708aecd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118274/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118274/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27876913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Ghareeb, Azza S.</creatorcontrib><creatorcontrib>Abd El Motaleb, Ghada S.</creatorcontrib><creatorcontrib>Waked, Nevien Maher</creatorcontrib><creatorcontrib>Osman Hany Kamel, Nancy</creatorcontrib><creatorcontrib>Aly, Nagwa Shaban</creatorcontrib><title>Circulating cathodic antigen cassette test versus haematuria strip test in diagnosis of urinary schistosomiasis</title><title>Journal of parasitic diseases</title><addtitle>J Parasit Dis</addtitle><addtitle>J Parasit Dis</addtitle><description>Urinary schistosomiasis caused by
Schistosoma haematobium
constitutes a major public health problem in many tropical and sub-tropical countries. This study was conducted to evaluate circulating cathodic antigen cassette test and haematuria strip test for detection of
S. haematobium
in urine samples and to evaluate their screening performance among the study population. Microscopy was used as a gold standard. A total of 600 urine samples were examined by microscopy for detection of
S. haematobium
eggs, screened for microhaematuria using Self-Stik reagent strips and screened for circulating cathodic antigen (CCA) using the urine-CCA cassette test. The specificity of CCA, microhaematuria and macrohaematuria was 96.4, 40.6 and 31.2 % respectively while the sensitivity was 88.2, 99.3 and 100 % respectively which was statistically significant (P < 0.001). These findings suggest that using of urine-CCA cassette test in diagnosis of urinary schistosomiasis is highly specific (96.4 %) compared with the highly sensitive haematuria strip test (100 %). The degree of agreement between microscopic examination and CCA detection was 99.3 % with highly statistically significant difference (P < 0.001). The combination of two techniques could potentially use for screening and mapping of S.
haematobium
infection.</description><subject>Antigens</subject><subject>Eggs</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hematuria</subject><subject>Infectious Diseases</subject><subject>Mapping</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy</subject><subject>Original</subject><subject>Original Article</subject><subject>Population studies</subject><subject>Public health</subject><subject>Schistosoma haematobium</subject><subject>Schistosomiasis</subject><subject>schistosomiasis haematobia</subject><subject>screening</subject><subject>Statistical analysis</subject><subject>Urine</subject><issn>0971-7196</issn><issn>0975-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNUcuKFTEQbURxHvoBbiTgxk1rJd3pJBtBLjoKA250HTLpdN8MfZNrKj3g31tjj8MoCK6SqnPq1OM0zQsObziAeotcDJ1pgcsWhl634lFzCkZRpKB7_OvPW8XNcNKcIV4DSMrrp82JUFoNhnenTd7F4tfF1Zhm5l3d5zF65lKNc0iUQAy1BlYDVnYTCq7I9i4cXF1LdAxriccNjImN0c0pY0SWJ0Z4cuUHQ7-PWDPmQ3QEPWueTG7B8PzuPW--ffzwdfepvfxy8Xn3_rL1PdeiHZQLSoIxXisYhZSBd1c0tOonOUyik-MEpgtKONBj74IPgoMzU69AUzR25827Tfe4Xh3C6EOqxS32WOKBprLZRfsnkuLezvnGSk79VU8Cr-8ESv6-0ob2ENGHZXEp5BWtAIBeGv0fVK77jo4tjSTqq7-o13ktiS5BLA266zQ3xOIby5eMWMJ0PzcHe-u83Zy35Ly9dd4Kqnn5cOH7it9WE0FsBCQozaE8aP1P1Z9koLt_</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>El-Ghareeb, Azza S.</creator><creator>Abd El Motaleb, Ghada S.</creator><creator>Waked, Nevien Maher</creator><creator>Osman Hany Kamel, Nancy</creator><creator>Aly, Nagwa Shaban</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20161201</creationdate><title>Circulating cathodic antigen cassette test versus haematuria strip test in diagnosis of urinary schistosomiasis</title><author>El-Ghareeb, Azza S. ; Abd El Motaleb, Ghada S. ; Waked, Nevien Maher ; Osman Hany Kamel, Nancy ; Aly, Nagwa Shaban</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4182-67ae75099c870d255e13b78774f56f235df093e72a08d4aece210a9f4708aecd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antigens</topic><topic>Eggs</topic><topic>Health Promotion and Disease Prevention</topic><topic>Hematuria</topic><topic>Infectious Diseases</topic><topic>Mapping</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy</topic><topic>Original</topic><topic>Original Article</topic><topic>Population studies</topic><topic>Public health</topic><topic>Schistosoma haematobium</topic><topic>Schistosomiasis</topic><topic>schistosomiasis haematobia</topic><topic>screening</topic><topic>Statistical analysis</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Ghareeb, Azza S.</creatorcontrib><creatorcontrib>Abd El Motaleb, Ghada S.</creatorcontrib><creatorcontrib>Waked, Nevien Maher</creatorcontrib><creatorcontrib>Osman Hany Kamel, Nancy</creatorcontrib><creatorcontrib>Aly, Nagwa Shaban</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of parasitic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Ghareeb, Azza S.</au><au>Abd El Motaleb, Ghada S.</au><au>Waked, Nevien Maher</au><au>Osman Hany Kamel, Nancy</au><au>Aly, Nagwa Shaban</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating cathodic antigen cassette test versus haematuria strip test in diagnosis of urinary schistosomiasis</atitle><jtitle>Journal of parasitic diseases</jtitle><stitle>J Parasit Dis</stitle><addtitle>J Parasit Dis</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>40</volume><issue>4</issue><spage>1193</spage><epage>1198</epage><pages>1193-1198</pages><issn>0971-7196</issn><eissn>0975-0703</eissn><abstract>Urinary schistosomiasis caused by
Schistosoma haematobium
constitutes a major public health problem in many tropical and sub-tropical countries. This study was conducted to evaluate circulating cathodic antigen cassette test and haematuria strip test for detection of
S. haematobium
in urine samples and to evaluate their screening performance among the study population. Microscopy was used as a gold standard. A total of 600 urine samples were examined by microscopy for detection of
S. haematobium
eggs, screened for microhaematuria using Self-Stik reagent strips and screened for circulating cathodic antigen (CCA) using the urine-CCA cassette test. The specificity of CCA, microhaematuria and macrohaematuria was 96.4, 40.6 and 31.2 % respectively while the sensitivity was 88.2, 99.3 and 100 % respectively which was statistically significant (P < 0.001). These findings suggest that using of urine-CCA cassette test in diagnosis of urinary schistosomiasis is highly specific (96.4 %) compared with the highly sensitive haematuria strip test (100 %). The degree of agreement between microscopic examination and CCA detection was 99.3 % with highly statistically significant difference (P < 0.001). The combination of two techniques could potentially use for screening and mapping of S.
haematobium
infection.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>27876913</pmid><doi>10.1007/s12639-015-0648-2</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens Eggs Health Promotion and Disease Prevention Hematuria Infectious Diseases Mapping Medicine Medicine & Public Health Microscopy Original Original Article Population studies Public health Schistosoma haematobium Schistosomiasis schistosomiasis haematobia screening Statistical analysis Urine |
| title | Circulating cathodic antigen cassette test versus haematuria strip test in diagnosis of urinary schistosomiasis |
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