Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer’s disease transgenic female mice

[Display omitted] The prevalence of Alzheimer’s disease (AD) is higher in females than in males, and causes more severe cognitive, memory and behavioral impairments. Previously, in male transgenic (Tg) APPSweDI mice, we reported that the novel lipophilic 1,4-dihydropyridine (DHP) derivative AP-12 cr...

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Veröffentlicht in:	Pharmacological research 2016-11, Vol.113 (Pt B), p.781-787
Hauptverfasser:	Jansone, Baiba, Kadish, Inga, van Groen, Thomas, Beitnere, Ulrika, Plotniece, Aiva, Pajuste, Karlis, Klusa, Vija
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Dihydropyridine derivative Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer’s disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Animals Anti-Anxiety Agents - pharmacology Anxiolytic effect Blood-Brain Barrier - metabolism Calcium - metabolism Calcium Channel Blockers - pharmacology Dihydropyridines - pharmacology Disease Models, Animal Female GABAergic Neurons - drug effects GABAergic Neurons - metabolism Glutamate Decarboxylase - metabolism Gyrus Cinguli - drug effects Gyrus Cinguli - metabolism Hippocampus - drug effects Hippocampus - metabolism Male Maze Learning - drug effects Memory Memory - drug effects Mice Mice, Transgenic Neuronal Plasticity - drug effects Protein expression Up-Regulation - drug effects Vesicular Inhibitory Amino Acid Transport Proteins - metabolism
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