Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains

Calpain-5 is a calcium-activated protease expressed in the retina. Mutations in calpain-5 cause autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, OMIM#193235). The structure of calpain-5 has not been determined, thus hindering the investigation of its proteolytic targets and path...

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Veröffentlicht in:	Journal of structural biology 2016-12, Vol.196 (3), p.309-318
Hauptverfasser:	Gakhar, Lokesh, Bassuk, Alexander G., Velez, Gabriel, Khan, Saif, Yang, Jing, Tsang, Stephen H., Mahajan, Vinit B.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADNIV Amino Acid Sequence - genetics Binding Sites Calcium - chemistry Calpain - chemistry Calpain - genetics Calpain - ultrastructure CAPN5 Catalytic Domain Humans Models, Molecular Mutation Protease Protein Conformation Protein Structure, Tertiary Retina - chemistry Retina - pathology SAXS Scattering, Small Angle Uveitis Vitreoretinopathy, Proliferative - genetics Vitreoretinopathy, Proliferative - pathology X-Rays
Online-Zugang:	Volltext
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