Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice

Diabetes, as a serious metobolic disorder, poses global threat to human health. It is estimated that over 50 million individuals are already affected by diabetes. Currently, diabetes-related osteoporosis has been a research hotspot due to its high incidence rate in older individuals. Osteoprotegerin...

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Veröffentlicht in:	International journal of molecular medicine 2016-12, Vol.38 (6), p.1661-1672
Hauptverfasser:	Li, Xue-Ju, Zhu, Zhe, Han, Si-Lin, Zhang, Zi-Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anti-Inflammatory Agents - pharmacology Biomarkers Bones Care and treatment Citrus fruits Cytokines Diabetes Diabetes Complications diabetes-related osteoporosis Disease Models, Animal Health aspects Humidity Immunohistochemistry JNK Mitogen-Activated Protein Kinases - metabolism JNK/MAPK Kinases Male Medical research Methoxsalen - analogs & derivatives Methoxsalen - pharmacology Mice Mice, Knockout NF-kappa B - metabolism nuclear factor-κB Oils & fats Osteoporosis Osteoporosis - etiology Osteoporosis - metabolism Osteoporosis - pathology osteoprotegerin Osteoprotegerin - deficiency Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT Proto-Oncogene Proteins c-akt - metabolism Risk factors Rodents Signal Transduction - drug effects Studies Western immunoblotting X-rays
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