BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer

The emergence of tumor cells with certain stem-like characteristics, such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 expression, contributes to chemotherapy resistance and tumor relapse. However, clinically applicable inhibitors of ALDH activity have not been reported. There is ev...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-11, Vol.76 (21), p.6320-6330
Hauptverfasser:	Yokoyama, Yuhki, Zhu, Hengrui, Lee, Jeong Heon, Kossenkov, Andrew V, Wu, Sherry Y, Wickramasinghe, Jayamanna M, Yin, Xiangfan, Palozola, Katherine C, Gardini, Alessandro, Showe, Louise C, Zaret, Kenneth S, Liu, Qin, Speicher, David, Conejo-Garcia, Jose R, Bradner, James E, Zhang, Zhiguo, Sood, Anil K, Ordog, Tamas, Bitler, Benjamin G, Zhang, Rugang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Dehydrogenase - antagonists & inhibitors Aldehyde Dehydrogenase - genetics Animals Azepines - pharmacology Carcinoma, Ovarian Epithelial Cell Line, Tumor Cisplatin - pharmacology Female Humans Mice Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - enzymology Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - physiology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - enzymology Transcription Factors - antagonists & inhibitors Transcription Factors - physiology Triazoles - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!