Familial aggregation of albuminuria and arterial hypertension in an Aboriginal Australian community and the contribution of variants in ACE and TP53

Aboriginal Australians are at high risk of cardiovascular, metabolic and renal diseases, resulting in a marked reduction in life expectancy when compared to the rest of the Australian population. This is partly due to recognized environmental and lifestyle risk factors, but a contribution of genetic...

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Veröffentlicht in:BMC nephrology 2016-11, Vol.17 (1), p.183, Article 183
Hauptverfasser: Duffy, David L, McDonald, Stephen P, Hayhurst, Beverley, Panagiotopoulos, Sianna, Smith, Trudy J, Wang, Xing L, Wilcken, David E, Duarte, Natalia L, Mathews, John, Hoy, Wendy E
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container_issue 1
container_start_page 183
container_title BMC nephrology
container_volume 17
creator Duffy, David L
McDonald, Stephen P
Hayhurst, Beverley
Panagiotopoulos, Sianna
Smith, Trudy J
Wang, Xing L
Wilcken, David E
Duarte, Natalia L
Mathews, John
Hoy, Wendy E
description Aboriginal Australians are at high risk of cardiovascular, metabolic and renal diseases, resulting in a marked reduction in life expectancy when compared to the rest of the Australian population. This is partly due to recognized environmental and lifestyle risk factors, but a contribution of genetic susceptibility is also likely. Using results from a comprehensive survey of one community (N = 1350 examined individuals), we have tested for familial aggregation of plasma glucose, arterial blood pressure, albuminuria (measured as urinary albumin to creatinine ratio, UACR) and estimated glomerular filtration rate (eGFR), and quantified the contribution of variation at four candidate genes (ACE; TP53; ENOS3; MTHFR). In the subsample of 357 individuals with complete genotype and phenotype data we showed that both UACR (h  = 64%) and blood pressure (sBP h  = 29%, dBP, h  = 11%) were significantly heritable. The ACE insertion-deletion (P = 0.0009) and TP53 codon72 polymorphisms (P = 0.003) together contributed approximately 15% of the total heritability of UACR, with an effect of ACE genotype on BP also clearly evident. While the effects of the ACE insertion-deletion on risk of renal disease (especially in the setting of diabetes) are well recognized, this is only the second study to implicate p53 genotype as a risk factor for albuminuria - the other being an earlier study we performed in a different Aboriginal community (McDonald et al., J Am Soc Nephrol 13: 677-83, 2002). We conclude that there are significant genetic contributions to the high prevalence of chronic diseases observed in this population.
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This is partly due to recognized environmental and lifestyle risk factors, but a contribution of genetic susceptibility is also likely. Using results from a comprehensive survey of one community (N = 1350 examined individuals), we have tested for familial aggregation of plasma glucose, arterial blood pressure, albuminuria (measured as urinary albumin to creatinine ratio, UACR) and estimated glomerular filtration rate (eGFR), and quantified the contribution of variation at four candidate genes (ACE; TP53; ENOS3; MTHFR). In the subsample of 357 individuals with complete genotype and phenotype data we showed that both UACR (h  = 64%) and blood pressure (sBP h  = 29%, dBP, h  = 11%) were significantly heritable. The ACE insertion-deletion (P = 0.0009) and TP53 codon72 polymorphisms (P = 0.003) together contributed approximately 15% of the total heritability of UACR, with an effect of ACE genotype on BP also clearly evident. 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subjects Adolescent
Adult
Aged
Albuminuria
Albuminuria - genetics
Albuminuria - urine
Arterial Pressure - genetics
Australian aborigines
Blood Glucose - genetics
Creatinine - urine
Female
Genes, p53
Genetic aspects
Genetic variation
Genotype
Glomerular Filtration Rate - genetics
Health aspects
Humans
Hypertension - genetics
INDEL Mutation
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Nephrology
Nitric Oxide Synthase Type III - genetics
Pedigree
Peptidyl-Dipeptidase A - genetics
Phenotype
Physiological aspects
Polymorphism, Genetic
Pulmonary hypertension
Risk factors
Surveys
Young Adult
title Familial aggregation of albuminuria and arterial hypertension in an Aboriginal Australian community and the contribution of variants in ACE and TP53
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