Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements
To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs). A total, 34 joints were the study group. Only patients, with a Wilkes stage of III,...
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| Veröffentlicht in: | Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2016-11, Vol.21 (6), p.e793-e799 |
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| creator | Leonardi, R Perrotta, R-E Almeida, L-E Loreto, C Musumeci, G |
| description | To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs).
A total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.
The mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.
The results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed. |
| doi_str_mv | 10.4317/medoral.21145 |
| format | Article |
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A total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.
The mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.
The results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed.</description><identifier>ISSN: 1698-6946</identifier><identifier>ISSN: 1698-4447</identifier><identifier>EISSN: 1698-6946</identifier><identifier>DOI: 10.4317/medoral.21145</identifier><identifier>PMID: 27694778</identifier><language>eng</language><publisher>Spain: Medicina Oral S.L</publisher><subject>Cross-Sectional Studies ; Dentistry ; Glycoproteins - analysis ; Humans ; Synovial Fluid - chemistry ; Temporomandibular Joint ; Temporomandibular Joint Disorders</subject><ispartof>Medicina oral, patología oral y cirugía bucal, 2016-11, Vol.21 (6), p.e793-e799</ispartof><rights>Copyright: © 2016 Medicina Oral S.L. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-73fec97f61742596a055ce6c2c019208e22f95df3884b8a04c8831f4dab863c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116123/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116123/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27694778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leonardi, R</creatorcontrib><creatorcontrib>Perrotta, R-E</creatorcontrib><creatorcontrib>Almeida, L-E</creatorcontrib><creatorcontrib>Loreto, C</creatorcontrib><creatorcontrib>Musumeci, G</creatorcontrib><title>Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements</title><title>Medicina oral, patología oral y cirugía bucal</title><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><description>To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs).
A total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.
The mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.
The results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed.</description><subject>Cross-Sectional Studies</subject><subject>Dentistry</subject><subject>Glycoproteins - analysis</subject><subject>Humans</subject><subject>Synovial Fluid - chemistry</subject><subject>Temporomandibular Joint</subject><subject>Temporomandibular Joint Disorders</subject><issn>1698-6946</issn><issn>1698-4447</issn><issn>1698-6946</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1LxDAQhoMo7rp69Co9eqkmTZukF0EWv2DBi548hDSdrJE2WZN2Yf-90V1lhcCEmWfeGeZF6Jzgq5ISft1D64PqrgpCyuoATQmrRc7qkh3u_SfoJMYPjCknnB2jScFTlnMxRW-LsQlWW5elFzfOr63qMtONts28yXrbtZlybRZhDQGyAfqVD75PKduMnQrZh7duSM0DBJc6WwjKLaEHN8RTdGRUF-FsF2fo9f7uZf6YL54fnua3i1xTwYecUwO65oYRXhZVzRSuKg1MFxqTusACisLUVWuoEGUjFC61EJSYslWNYFQzOkM3W93V2KRz6DQ7XUSugu1V2EivrPxfcfZdLv1aVoQwUtAkcLkTCP5zhDjI3kYNXacc-DFKImhFE0xFQvMtqoOPMYD5G0Ow_DZE7gyRP4Yk_mJ_tz_61wH6BW9Zirw</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Leonardi, R</creator><creator>Perrotta, R-E</creator><creator>Almeida, L-E</creator><creator>Loreto, C</creator><creator>Musumeci, G</creator><general>Medicina Oral S.L</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161101</creationdate><title>Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements</title><author>Leonardi, R ; Perrotta, R-E ; Almeida, L-E ; Loreto, C ; Musumeci, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-73fec97f61742596a055ce6c2c019208e22f95df3884b8a04c8831f4dab863c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cross-Sectional Studies</topic><topic>Dentistry</topic><topic>Glycoproteins - analysis</topic><topic>Humans</topic><topic>Synovial Fluid - chemistry</topic><topic>Temporomandibular Joint</topic><topic>Temporomandibular Joint Disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leonardi, R</creatorcontrib><creatorcontrib>Perrotta, R-E</creatorcontrib><creatorcontrib>Almeida, L-E</creatorcontrib><creatorcontrib>Loreto, C</creatorcontrib><creatorcontrib>Musumeci, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leonardi, R</au><au>Perrotta, R-E</au><au>Almeida, L-E</au><au>Loreto, C</au><au>Musumeci, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements</atitle><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>21</volume><issue>6</issue><spage>e793</spage><epage>e799</epage><pages>e793-e799</pages><issn>1698-6946</issn><issn>1698-4447</issn><eissn>1698-6946</eissn><abstract>To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs).
A total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.
The mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.
The results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed.</abstract><cop>Spain</cop><pub>Medicina Oral S.L</pub><pmid>27694778</pmid><doi>10.4317/medoral.21145</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Cross-Sectional Studies Dentistry Glycoproteins - analysis Humans Synovial Fluid - chemistry Temporomandibular Joint Temporomandibular Joint Disorders |
| title | Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements |
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