Synergistic Allosteric Mechanism of FBP and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis

Pyruvate kinase M2 (PKM2) plays a key role in tumor metabolism and regulates the rate-limiting final step of glycolysis. In tumor cells, there are two allosteric effectors of fructose-1,6-bisphosphate (FBP) and serine for PKM2. However, the relationship between FBP and serine for allosteric regulati...

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Veröffentlicht in:	Journal of chemical information and modeling 2016-06, Vol.56 (6), p.1184-1192
Hauptverfasser:	Yang, Jingxu, Liu, Hao, Liu, Xiaorui, Gu, Chengbo, Luo, Ray, Chen, Hai-Feng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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