Interactions between the microbiota and pathogenic bacteria in the gut
The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic popu...
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| Veröffentlicht in: | Nature (London) 2016-07, Vol.535 (7610), p.85-93 |
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| creator | Bäumler, Andreas J. Sperandio, Vanessa |
| description | The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases. |
| doi_str_mv | 10.1038/nature18849 |
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Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. 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| subjects | 631/326 Animals Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacteria - drug effects Bacteria - growth & development Bacteria - metabolism Bacteria - pathogenicity Bacterial infections Bacterial Infections - metabolism Bacterial Infections - microbiology Bacterial Infections - therapy Carbon - metabolism Comparative analysis Digestive system Disease Resistance Gastrointestinal Microbiome - drug effects Host-parasite relationships Humanities and Social Sciences Humans Infectious diseases Inflammation - metabolism Inflammation - microbiology Intestinal Mucosa - metabolism Intestines - drug effects Intestines - microbiology Microbial Interactions - drug effects Microorganisms multidisciplinary Nitrogen - metabolism Pathogenesis review-article Science Signal Transduction Studies Virulence - physiology |
| title | Interactions between the microbiota and pathogenic bacteria in the gut |
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