Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis

Peripheral CD27 + memory B-cells become quantitatively reduced and dysfunctional in patients with cirrhosis through poorly characterized mechanisms. We hypothesized that the disappearance of CD27 + memory B-cells results from enhanced sensitivity to apoptosis caused by exposure to gut microbial tran...

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Veröffentlicht in:	Scientific reports 2016-11, Vol.6 (1), p.36862-36862, Article 36862
Hauptverfasser:	Chang, Li-Yuan, Li, Yonghai, Kaplan, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/2 13/21 13/31 631/250/1932 631/250/2520 692/4020/4021/1607/1604 Aged Apoptosis B-cell receptor B-Lymphocytes - chemistry B-Lymphocytes - pathology CD27 antigen CD95 antigen Cirrhosis Endotoxemia Endotoxemia - pathology Endotoxins fas Receptor - analysis Female Fibrosis - complications Humanities and Social Sciences Humans Immunodeficiency Immunological memory Intestinal microflora Liver cirrhosis Liver diseases Lymphocytes B Male Memory cells Middle Aged multidisciplinary Protein Binding Science TLR4 protein Toll-like receptors Translocation Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis
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