DNA polymerase θ (POLQ), double-strand break repair, and cancer

DNA polymerase theta (pol θ) is encoded in the genomes of many eukaryotes, though not in fungi. Pol θ is encoded by the POLQ gene in mammalian cells. The C-terminal third of the protein is a family A DNA polymerase with additional insertion elements relative to prokaryotic homologs. The N-terminal t...

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Veröffentlicht in:	DNA repair 2016-08, Vol.44, p.22-32
Hauptverfasser:	Wood, Richard D., Doublié, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative end-joining Animals Antineoplastic Combined Chemotherapy Protocols Base Pair Mismatch Catalytic Domain DNA - genetics DNA - metabolism DNA Breaks, Double-Stranded DNA double strand breaks DNA End-Joining Repair DNA Mismatch Repair DNA polymerase DNA Polymerase theta DNA synthesis DNA, Neoplasm - antagonists & inhibitors DNA, Neoplasm - genetics DNA, Neoplasm - metabolism DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Enzyme Inhibitors Gamma Rays Humans MMEJ Models, Molecular Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Recombinational DNA Repair Synthetic lethality Treatment Outcome
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