Diverse Intestinal Bacteria Contain Putative Zwitterionic Capsular Polysaccharides with Anti-inflammatory Properties

Zwitterionic capsular polysaccharides (ZPSs) are bacterial products that modulate T cells, including inducing anti-inflammatory IL-10-secreting T regulatory cells (Tregs). However, only a few diverse bacteria are known to modulate the host immune system via ZPS. We present a genomic screen for bacte...

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Veröffentlicht in:	Cell host & microbe 2016-10, Vol.20 (4), p.535-547
Hauptverfasser:	Neff, C. Preston, Rhodes, Matthew E., Arnolds, Kathleen L., Collins, Colm B., Donnelly, Jody, Nusbacher, Nichole, Jedlicka, Paul, Schneider, Jennifer M., McCarter, Martin D., Shaffer, Michael, Mazmanian, Sarkis K., Palmer, Brent E., Lozupone, Catherine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - metabolism Bacteria - chemistry Colitis - pathology Disease Models, Animal Humans Immune Tolerance Interleukin-10 - secretion Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Mice Polysaccharides, Bacterial - metabolism T-Lymphocytes, Regulatory - immunology
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