Salvianolic acid B reduced the formation of epidural fibrosis in an experimental rat model
Salvianolic acid B (Sal B) was newly reported to be able to attenuate fibrosis in the animal model. The aim of the present study was to investigate the effect of the intragastric application of Sal B on the prevention of epidural fibrosis (EF). Forty healthy adult male Wistar rats were divided into...
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| Veröffentlicht in: | Journal of orthopaedic surgery and research 2016-11, Vol.11 (1), p.141-141, Article 141 |
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| creator | Chen, Feng Wang, Changyao Sun, Jintang Wang, Jin Wang, Lanfeng Li, Jianmin |
| description | Salvianolic acid B (Sal B) was newly reported to be able to attenuate fibrosis in the animal model. The aim of the present study was to investigate the effect of the intragastric application of Sal B on the prevention of epidural fibrosis (EF).
Forty healthy adult male Wistar rats were divided into four treatment groups (n = 10 per group): (1) 10 mg/kg Sal B, (2) 30 mg/kg Sal B, (3) 50 mg/kg Sal B and (4) Saline (vehicle treatment, control group). All animals underwent a laminectomy at the lumbar 1-2 (L 1-2) level. After intragastric treatment, all rats were sacrificed at post-operative week 8. The extent of the epidural scar, the regeneration of the vasculature and the expression levels of vascular endothelial growth factor (VEGF) were analysed.
The animals' recovery was uneventful during the experimental period. The extent of the epidural scar, the regeneration of the vasculature and the expression levels of VEGF suggested better outcomes in the Sal B-treated groups. Sal B exerted the ability to prevent the formation of an epidural scar and vascularization at the laminectomy sites. The effects of Sal B were dose-dependent, with the 50 mg/kg Sal B group showing the best outcomes compared with the other groups.
Post-operative intragastric application of Sal B can prevent the formation of epidural scarring. Sal B exerted these effects in a dose-dependent manner, and 50 mg/kg dose was shown to be the best effect in the present study. The results of this study reveal that Sal B could be a potential therapy for EF and valuable for further research. |
| doi_str_mv | 10.1186/s13018-016-0475-x |
| format | Article |
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Forty healthy adult male Wistar rats were divided into four treatment groups (n = 10 per group): (1) 10 mg/kg Sal B, (2) 30 mg/kg Sal B, (3) 50 mg/kg Sal B and (4) Saline (vehicle treatment, control group). All animals underwent a laminectomy at the lumbar 1-2 (L 1-2) level. After intragastric treatment, all rats were sacrificed at post-operative week 8. The extent of the epidural scar, the regeneration of the vasculature and the expression levels of vascular endothelial growth factor (VEGF) were analysed.
The animals' recovery was uneventful during the experimental period. The extent of the epidural scar, the regeneration of the vasculature and the expression levels of VEGF suggested better outcomes in the Sal B-treated groups. Sal B exerted the ability to prevent the formation of an epidural scar and vascularization at the laminectomy sites. The effects of Sal B were dose-dependent, with the 50 mg/kg Sal B group showing the best outcomes compared with the other groups.
Post-operative intragastric application of Sal B can prevent the formation of epidural scarring. Sal B exerted these effects in a dose-dependent manner, and 50 mg/kg dose was shown to be the best effect in the present study. The results of this study reveal that Sal B could be a potential therapy for EF and valuable for further research.</description><identifier>ISSN: 1749-799X</identifier><identifier>EISSN: 1749-799X</identifier><identifier>DOI: 10.1186/s13018-016-0475-x</identifier><identifier>PMID: 27852325</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Benzofurans - pharmacology ; Benzofurans - therapeutic use ; Cell Proliferation - drug effects ; Cell Proliferation - physiology ; Complications and side effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Epidural Space - diagnostic imaging ; Epidural Space - pathology ; Fibrosis ; Fibrosis - pathology ; Fibrosis - prevention & control ; Laminectomy ; Male ; Medicine, Chinese ; Orthopedics ; Patient outcomes ; Physiological aspects ; Prevention ; Rats ; Rats, Wistar ; Risk factors</subject><ispartof>Journal of orthopaedic surgery and research, 2016-11, Vol.11 (1), p.141-141, Article 141</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-c8da79cfc27c794277e1e47606f85520448866d43db9abef6dc873243bfd55ee3</citedby><cites>FETCH-LOGICAL-c560t-c8da79cfc27c794277e1e47606f85520448866d43db9abef6dc873243bfd55ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112727/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112727/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27852325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Wang, Changyao</creatorcontrib><creatorcontrib>Sun, Jintang</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Wang, Lanfeng</creatorcontrib><creatorcontrib>Li, Jianmin</creatorcontrib><title>Salvianolic acid B reduced the formation of epidural fibrosis in an experimental rat model</title><title>Journal of orthopaedic surgery and research</title><addtitle>J Orthop Surg Res</addtitle><description>Salvianolic acid B (Sal B) was newly reported to be able to attenuate fibrosis in the animal model. The aim of the present study was to investigate the effect of the intragastric application of Sal B on the prevention of epidural fibrosis (EF).
Forty healthy adult male Wistar rats were divided into four treatment groups (n = 10 per group): (1) 10 mg/kg Sal B, (2) 30 mg/kg Sal B, (3) 50 mg/kg Sal B and (4) Saline (vehicle treatment, control group). All animals underwent a laminectomy at the lumbar 1-2 (L 1-2) level. After intragastric treatment, all rats were sacrificed at post-operative week 8. The extent of the epidural scar, the regeneration of the vasculature and the expression levels of vascular endothelial growth factor (VEGF) were analysed.
The animals' recovery was uneventful during the experimental period. The extent of the epidural scar, the regeneration of the vasculature and the expression levels of VEGF suggested better outcomes in the Sal B-treated groups. Sal B exerted the ability to prevent the formation of an epidural scar and vascularization at the laminectomy sites. The effects of Sal B were dose-dependent, with the 50 mg/kg Sal B group showing the best outcomes compared with the other groups.
Post-operative intragastric application of Sal B can prevent the formation of epidural scarring. Sal B exerted these effects in a dose-dependent manner, and 50 mg/kg dose was shown to be the best effect in the present study. The results of this study reveal that Sal B could be a potential therapy for EF and valuable for further research.</description><subject>Animals</subject><subject>Benzofurans - pharmacology</subject><subject>Benzofurans - therapeutic use</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Proliferation - physiology</subject><subject>Complications and side effects</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Epidural Space - diagnostic imaging</subject><subject>Epidural Space - pathology</subject><subject>Fibrosis</subject><subject>Fibrosis - pathology</subject><subject>Fibrosis - prevention & control</subject><subject>Laminectomy</subject><subject>Male</subject><subject>Medicine, Chinese</subject><subject>Orthopedics</subject><subject>Patient outcomes</subject><subject>Physiological aspects</subject><subject>Prevention</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Risk factors</subject><issn>1749-799X</issn><issn>1749-799X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkk9rFTEUxQex2Fr9AG4k4MbNtPk7yWyEWqwKhS6qIG5CJrlpU2aSZzJTnt--GV6trUgWCbm_c3JvOE3zhuAjQlR3XAjDRLWYdC3mUrTbZ80BkbxvZd__eP7ovN-8LOUGY4GF4i-afSqVoIyKg-bnpRlvg4lpDBYZGxz6iDK4xYJD8zUgn_Jk5pAiSh7BJrglmxH5MORUQkEhIhMRbDeQwwRxrrVsZjQlB-OrZs-bscDr-_2w-X726dvpl_b84vPX05Pz1ooOz61VzsjeekullT2nUgIBLjvceSUExZwr1XWOMzf0ZgDfOasko5wN3gkBwA6bDzvfzTJM4Gxto_aoN7Ujk3_rZIJ-WonhWl-lWy0IoZLKavD-3iCnXwuUWU-hWBhHEyEtRRPFCWFM0b6i7_5Bb9KSYx1vpYQSXDD8l7oyI-gQfarv2tVUn3CJV4ySSh39h6rLwRRsiuBDvX8iIDuBrZ9fMviHGQnWayD0LhC6BkKvgdDbqnn7-HMeFH8SwO4AhgyxAg</recordid><startdate>20161116</startdate><enddate>20161116</enddate><creator>Chen, Feng</creator><creator>Wang, Changyao</creator><creator>Sun, Jintang</creator><creator>Wang, Jin</creator><creator>Wang, Lanfeng</creator><creator>Li, Jianmin</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161116</creationdate><title>Salvianolic acid B reduced the formation of epidural fibrosis in an experimental rat model</title><author>Chen, Feng ; Wang, Changyao ; Sun, Jintang ; Wang, Jin ; Wang, Lanfeng ; Li, Jianmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-c8da79cfc27c794277e1e47606f85520448866d43db9abef6dc873243bfd55ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Benzofurans - pharmacology</topic><topic>Benzofurans - therapeutic use</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Proliferation - physiology</topic><topic>Complications and side effects</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Epidural Space - diagnostic imaging</topic><topic>Epidural Space - pathology</topic><topic>Fibrosis</topic><topic>Fibrosis - pathology</topic><topic>Fibrosis - prevention & control</topic><topic>Laminectomy</topic><topic>Male</topic><topic>Medicine, Chinese</topic><topic>Orthopedics</topic><topic>Patient outcomes</topic><topic>Physiological aspects</topic><topic>Prevention</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Wang, Changyao</creatorcontrib><creatorcontrib>Sun, Jintang</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Wang, Lanfeng</creatorcontrib><creatorcontrib>Li, Jianmin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of orthopaedic surgery and research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Feng</au><au>Wang, Changyao</au><au>Sun, Jintang</au><au>Wang, Jin</au><au>Wang, Lanfeng</au><au>Li, Jianmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salvianolic acid B reduced the formation of epidural fibrosis in an experimental rat model</atitle><jtitle>Journal of orthopaedic surgery and research</jtitle><addtitle>J Orthop Surg Res</addtitle><date>2016-11-16</date><risdate>2016</risdate><volume>11</volume><issue>1</issue><spage>141</spage><epage>141</epage><pages>141-141</pages><artnum>141</artnum><issn>1749-799X</issn><eissn>1749-799X</eissn><abstract>Salvianolic acid B (Sal B) was newly reported to be able to attenuate fibrosis in the animal model. The aim of the present study was to investigate the effect of the intragastric application of Sal B on the prevention of epidural fibrosis (EF).
Forty healthy adult male Wistar rats were divided into four treatment groups (n = 10 per group): (1) 10 mg/kg Sal B, (2) 30 mg/kg Sal B, (3) 50 mg/kg Sal B and (4) Saline (vehicle treatment, control group). All animals underwent a laminectomy at the lumbar 1-2 (L 1-2) level. After intragastric treatment, all rats were sacrificed at post-operative week 8. The extent of the epidural scar, the regeneration of the vasculature and the expression levels of vascular endothelial growth factor (VEGF) were analysed.
The animals' recovery was uneventful during the experimental period. The extent of the epidural scar, the regeneration of the vasculature and the expression levels of VEGF suggested better outcomes in the Sal B-treated groups. Sal B exerted the ability to prevent the formation of an epidural scar and vascularization at the laminectomy sites. The effects of Sal B were dose-dependent, with the 50 mg/kg Sal B group showing the best outcomes compared with the other groups.
Post-operative intragastric application of Sal B can prevent the formation of epidural scarring. Sal B exerted these effects in a dose-dependent manner, and 50 mg/kg dose was shown to be the best effect in the present study. The results of this study reveal that Sal B could be a potential therapy for EF and valuable for further research.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27852325</pmid><doi>10.1186/s13018-016-0475-x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Animals Benzofurans - pharmacology Benzofurans - therapeutic use Cell Proliferation - drug effects Cell Proliferation - physiology Complications and side effects Disease Models, Animal Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Epidural Space - diagnostic imaging Epidural Space - pathology Fibrosis Fibrosis - pathology Fibrosis - prevention & control Laminectomy Male Medicine, Chinese Orthopedics Patient outcomes Physiological aspects Prevention Rats Rats, Wistar Risk factors |
| title | Salvianolic acid B reduced the formation of epidural fibrosis in an experimental rat model |
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