Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target

The aetiology of intervertebral disc (IVD) degeneration remains poorly understood. Painful IVD degeneration is associated with an acidic intradiscal pH but the response of NP cells to this aberrant microenvironmental factor remains to be fully characterised. The aim here was to address the hypothesi...

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Veröffentlicht in:	Scientific reports 2016-11, Vol.6 (1), p.37360-37360, Article 37360
Hauptverfasser:	Gilbert, Hamish T. J., Hodson, Nathan, Baird, Pauline, Richardson, Stephen M., Hoyland, Judith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 14/63 38 38/77 631/337 631/80/304 82 82/1 82/51 96 Acid Sensing Ion Channel Blockers - pharmacology Acid Sensing Ion Channels - genetics Acid Sensing Ion Channels - metabolism Acidity Acids Apoptosis Back pain Biology Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - genetics Cell growth Cell Proliferation Cell Survival Cells, Cultured Cnidarian Venoms - pharmacology Cytokines Cytokines - biosynthesis Cytokines - genetics Degeneration Degenerative disc disease Drug Evaluation, Preclinical Enzymes Female Gene expression Genotype & phenotype Humanities and Social Sciences Humans Hydrogen-Ion Concentration Inflammation Intervertebral Disc Degeneration - drug therapy Intervertebral Disc Degeneration - metabolism Male Medicine Metabolites Middle Aged Molecular Targeted Therapy multidisciplinary Nerve Growth Factor - biosynthesis Nerve Growth Factor - genetics Nucleus Pulposus - pathology Nutrients Pain pH effects Proteins Science Sodium channels Transcriptional Activation
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